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mAbs Volume 9, 2017 - Issue 3
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The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry

Renpeng LiuAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USACorrespondence[email protected] [email protected]
,
Xuan ChenAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USA
,
Junia DushimeAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USA
,
Megan BogalhasAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USA
,
Alexandru C. LazarAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USA
,
Thomas RyllAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USA
&
Lintao WangAnalytical and Pharmaceutical Science Department, ImmunoGen Inc.Waltham, MA, USACorrespondence[email protected] [email protected]
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Pages 490-497 | Received 07 Nov 2016, Accepted 18 Jan 2017, Published online: 02 Mar 2017

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Alain Beck, Valentina D’Atri, Anthony Ehkirch, Szabolcs Fekete, Oscar Hernandez-Alba, Rabah Gahoual, Emmanuel Leize-Wagner, Yannis François, Davy Guillarme & Sarah Cianférani. (2019) Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future. Expert Review of Proteomics 16:4, pages 337-362.
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Lily Liu-Shin, Adam Fung, Arun Malhotra & Gayathri Ratnaswamy. (2018) Influence of disulfide bond isoforms on drug conjugation sites in cysteine-linked IgG2 antibody-drug conjugates. mAbs 10:4, pages 583-595.
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Xiaoyue Song, Huairu Tian & Guolin Zhang. Application of capillary electrophoresis-sodium dodecyl sulfate in assessing the purity of monoclonal antibody biopharmaceuticals. Journal of Liquid Chromatography & Related Technologies 0:0, pages 1-11.
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Articles from other publishers (9)

Karoline Bechtold-Peters, Andrea Ruggiero, Nienke Vriezen, Nathan Ihle, Armin Klein, Charles Morgan, Daniel Schweizer, Dengfeng Liu, Fred Jacobson, Jakob Buecheler, Mark Panek, Naomi Duggan, Padma Malyala, Philippe Dupraz, Priyanka Desai, Shufang Niu, Yiqing Feng & Xiangyang Wang. (2023) CMC Regulatory Considerations for Antibody-Drug Conjugates. Journal of Pharmaceutical Sciences 112:12, pages 2965-2980.
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Zhiyuan Sun, Maggie Huang, Izabela Sokolowska, Rui Cao, Kern Chang, Ping Hu & Jingjie Mo. (2023) Impact of Trisulfide on the Structure and Function of Different Antibody Constructs. Journal of Pharmaceutical Sciences 112:10, pages 2637-2643.
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Malte Renz & Oliver Dorigo. 2023. DiSaia and Creasman Clinical Gynecologic Oncology. DiSaia and Creasman Clinical Gynecologic Oncology 506 520.e7 .
Shun‐Yu Wu, Fu‐Gen Wu & Xiaoyuan Chen. (2022) Antibody‐Incorporated Nanomedicines for Cancer Therapy. Advanced Materials 34:24.
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Ramesh Kumar, Andras Guttman & Anurag S. Rathore. (2021) Applications of capillary electrophoresis for biopharmaceutical product characterization. ELECTROPHORESIS 43:1-2, pages 143-166.
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T. Shantha Raju. 2019. Co and Post‐Translational Modifications of Therapeutic Antibodies and Proteins. Co and Post‐Translational Modifications of Therapeutic Antibodies and Proteins 35 38 .
Michael B. Hippach, Ian Schwartz, Jian Pei, Jimmy Huynh, Yasuaki Kawai & Marie M. Zhu. (2018) Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl‐drug conjugation process. Biotechnology Progress 34:6, pages 1427-1437.
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James Bonner, Lance E. Talbert, Nicholas Akkawi & Ryan R. Julian. (2018) Simplified identification of disulfide, trisulfide, and thioether pairs with 213 nm UVPD. The Analyst 143:21, pages 5176-5184.
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Olivier Marcq. 2018. Innovations for Next-Generation Antibody-Drug Conjugates. Innovations for Next-Generation Antibody-Drug Conjugates 113 161 .

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