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Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

Hsueh-Yuan Changa Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USAORCID Iconhttps://orcid.org/0000-0002-2076-8477
ORCID Icon,
Shengjia Wua Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA
,
Yingyi Lia Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA
,
Wanying Zhanga Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA
,
Matthew Burrellb Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Cambridge, UK
,
Carl I. Websterb Antibody Discovery and Protein Engineering, R&D, AstraZeneca, Cambridge, UK
&
Dhaval K. Shaha Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0723-6206
ORCID Icon show all
Article: 1874121 | Received 02 Nov 2020, Accepted 06 Jan 2021, Published online: 26 Jan 2021

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Habib Baghirov. (2023) Receptor-mediated transcytosis of macromolecules across the blood–brain barrier. Expert Opinion on Drug Delivery 0:0, pages 1-13.
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Maria A. Argiriadi, Kangwen Deng, David Egan, Lei Gao, Farid Gizatullin, John Harlan, Denise Karaoglu Hanzatian, Wei Qiu, Ruth Villanueva & Andrew Goodearl. (2023) The use of cyclic peptide antigens to generate LRP8 specific antibodies. Frontiers in Drug Discovery 2.
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Hsueh-Yuan Chang, Shengjia Wu, Ekram Ahmed Chowdhury & Dhaval K. Shah. (2022) Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central nervous system. Journal of Pharmacokinetics and Pharmacodynamics 49:3, pages 337-362.
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William M. Pardridge. (2021) Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor. Pharmaceuticals 15:1, pages 3.
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