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mAbs Volume 13, 2021 - Issue 1
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An integrated approach for characterizing immunogenic responses toward a bispecific antibody

Sivan Cohena Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USA
,
Shan Chunga Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-5494-2103
ORCID Icon,
Christoph Spiessb Department of Antibody Engineering, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-0570-9700
ORCID Icon,
Victor Lundinc Department of Protein Analytical Chemistry, Genentech Inc, South San Francisco, CA, USA
,
Eric Stefanichd Genentech Inc, South San Francisco, CA, USA
,
Steven T. Lainge Department of Safety Assessment, Genentech Inc, South San Francisco, CA, USA
,
Vanessa Clarke Department of Safety Assessment, Genentech Inc, South San Francisco, CA, USA
,
Jochen Brummf Department of Biostatistics, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0001-9518-038X
ORCID Icon,
Ying Zhoua Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USA
,
Catherine Huanga Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USA
,
Joyce Guerreroa Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USA
,
Srividya Mynenia Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USA
,
Rajbharan Yadavd Genentech Inc, South San Francisco, CA, USA
,
Ketevan Siradzea Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USA
&
Kun Penga Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0480-073X
ORCID Icon show all
Article: 1944017 | Received 09 Apr 2021, Accepted 14 Jun 2021, Published online: 05 Jul 2021

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Kathryn Ball, Simon J Dovedi, Pavan Vajjah & Alex Phipps. (2023) Strategies for clinical dose optimization of T cell-engaging therapies in oncology. mAbs 15:1.
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Md Harunur Rashid. (2022) Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation. mAbs 14:1.
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Arthur J. Schick$suffix/text()$suffix/text(), Victor Lundin, Justin Low, Kun Peng, Richard Vandlen & Aaron T. Wecksler. (2022) Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody. mAbs 14:1.
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Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka & Simon Krah. (2022) Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities. mAbs 14:1.
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Articles from other publishers (3)

Punit Upadhyaya, Julia KristenssonJohanna Lahdenranta, Elizabeth Repash, Jun Ma, Jessica Kublin, Gemma E. Mudd, Lia Luus, Phil JeffreyKristen Hurov, Kevin McDonnell & Nicholas Keen. (2022) Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology. Journal of Medicinal Chemistry 65:14, pages 9858-9872.
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Shun‐Yu Wu, Fu‐Gen Wu & Xiaoyuan Chen. (2022) Antibody‐Incorporated Nanomedicines for Cancer Therapy. Advanced Materials 34:24.
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Rajbharan Yadav, Siddharth Sukumaran, Tanja S. Zabka, Jinze Li, Amy Oldendorp, Gary Morrow, Arthur Reyes, Melissa Cheu, Jessica Li, Jeffrey J. Wallin, Siao Tsai, Laura Sun, Peiyin Wang, Diego Ellerman, Christoph Spiess, Andy Polson, Eric G. Stefanich, Amrita V. Kamath & Meric A. Ovacik. (2022) Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies. Pharmaceutics 14:5, pages 970.
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