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Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery

Pawel Dudzica NaturalAntibody, Szczecin, PolandView further author information

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Dawid Chomicza NaturalAntibody, Szczecin, PolandView further author information

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Jarosław Kończaka NaturalAntibody, Szczecin, PolandView further author information

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Tadeusz Satławaa NaturalAntibody, Szczecin, PolandView further author information

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Bartosz Janusza NaturalAntibody, Szczecin, PolandView further author information

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Sonia Wrobela NaturalAntibody, Szczecin, PolandView further author information

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Tomasz Gawłowskia NaturalAntibody, Szczecin, PolandView further author information

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Igor Jaszczyszyna NaturalAntibody, Szczecin, PolandView further author information

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Weronika Bielskaa NaturalAntibody, Szczecin, PolandView further author information

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Samuel Demharterb Discovery Data Science, Genmab, Copenhagen, DenmarkView further author information

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Roberto Spreaficoc Discovery Data Science, Genmab, Utrecht, The Netherlands

https://orcid.org/0000-0001-8282-7658 View further author information

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Lukas Schulted Global Computational Biology & Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, GermanyView further author information

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Kyle Martine Biotherapeutics Discovery, Boehringer Ingelheim, Ridgefield, CT, USAView further author information

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Stephen R. Comeaue Biotherapeutics Discovery, Boehringer Ingelheim, Ridgefield, CT, USAView further author information

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Konrad Krawczyka NaturalAntibody, Szczecin, PolandCorrespondence[email protected]

https://orcid.org/0000-0003-0697-5522 View further author information