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Short Communication

The function of Shoc2: A scaffold and beyond

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Article: e1188241 | Received 29 Apr 2016, Accepted 05 May 2016, Published online: 18 May 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Wenwen Geng, Meiling Cao, Ke Dong, Junhua An & Haidong Gao. (2023) SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus. Cancer Biology & Therapy 24:1.
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Jason J. Kwon & William C. Hahn. (2021) A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and Cellular Biology 41:4.
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Articles from other publishers (22)

Udeep Chawla & Deepak Chopra. (2022) Structural Advancement in Shoc2‐MAPK Signaling Pathways in the Treatment of Cancer and Other Diseases. ChemistrySelect 7:48.
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Rebecca G. Norcross, Lina Abdelmoti, Eric C. Rouchka, Kalina Andreeva, Olivia Tussey, Daileen Landestoy & Emilia Galperin. (2022) Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. Developmental Biology 492, pages 156-171.
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Mingjia Tan, Yu Chang, Xiaoqiang Liu, Hua Li, Zaiming Tang, Mukesh K. Nyati & Yi Sun. (2022) The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Cell Reports 41:12, pages 111837.
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Shu-Er Chow, Yaa-Jyuhn J. Meir, Jhy-Ming Li, Ping-Chih Hsu & Cheng-Ta Yang. (2022) Nuclear p120 catenin is a component of the perichromosomal layer and coordinates sister chromatid segregation during mitosis in lung cancer cells. Cell Death & Disease 13:6.
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Ezekiel Gonzalez-Fernandez, Letao Fan, Shaoxun Wang, Yedan Liu, Wenjun Gao, Kirby N. Thomas, Fan Fan & Richard J. Roman. (2022) The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension—vascular, renal, and cognitive diseases. Physiological Genomics 54:2, pages 58-70.
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Bao-Rui Zhao, Xin-Xin Wang & Xian-Wei Wang. (2022) Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate. PLOS Pathogens 18:1, pages e1010253.
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Patricia Wilson, Lina Abdelmoti, Rebecca Norcross, Eun Ryoung Jang, Malathy Palayam & Emilia Galperin. (2021) The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair. Journal of Cell Science 134:21.
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HyeIn Jang, Payton Stevens, Tianyan Gao & Emilia Galperin. (2020) The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease. The FEBS Journal 288:3, pages 721-739.
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Jin-Fan Zhang, Sohum MehtaJin Zhang. (2021) Signaling Microdomains in the Spotlight: Visualizing Compartmentalized Signaling Using Genetically Encoded Fluorescent Biosensors. Annual Review of Pharmacology and Toxicology 61:1, pages 587-608.
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Peter J. M. van Haastert. (2020) Unified control of amoeboid pseudopod extension in multiple organisms by branched F-actin in the front and parallel F-actin/myosin in the cortex. PLOS ONE 15:12, pages e0243442.
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Andrea M. Gross, Megan Frone, Karen W. Gripp, Bruce D. Gelb, Lisa Schoyer, Lisa Schill, Beth Stronach, Leslie G. Biesecker, Dominic Esposito, Edjay Ralph Hernandez, Eric Legius, Mignon L. Loh, Staci Martin, Deborah K. Morrison, Katherine A. Rauen, Pamela L. Wolters, Dina Zand, Frank McCormick, Sharon A. Savage, Douglas R. Stewart, Brigitte C. Widemann & Marielle E. Yohe. (2020) Advancing RAS/RASopathy therapies: An NCI‐sponsored intramural and extramural collaboration for the study of RASopathies . American Journal of Medical Genetics Part A 182:4, pages 866-876.
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Kyoko KUDO, Junichiro OKADA, Mao SATAKE, Takeshi KUSUDA & Masutaka FURUE. (2020) A Case of Noonan Syndrome-like Disorder with Loose Anagen HairNoonan Syndrome-like Disorder with Loose Anagen Hair の 1 例. Nishi Nihon Hifuka 82:1, pages 28-31.
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HyeIn Jang, Patricia G. Wilson, Mary Sau, Udeep Chawla, David W. Rodgers & Emilia Galperin. (2020) Single-domain antibodies for functional targeting of the signaling scaffold Shoc2. Molecular Immunology 118, pages 110-116.
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Wenwen Geng, Ke Dong, Qian Pu, Yanrong Lv & Haidong Gao. (2019) SHOC2 is associated with the survival of breast cancer cells and has prognostic value for patients with breast cancer. Molecular Medicine Reports.
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Yongbo Xue, Joanna C. Chiu & Yong Zhang. (2019) SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila. PLOS Genetics 15:11, pages e1008475.
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Isabel Boned del RíoLucy C. YoungSibel SariGreg G. JonesBenjamin Ringham-Terry, Nicole HartigEwa RejnowiczWinnie LeiAmandeep Bhamra, Silvia Surinova & Pablo Rodriguez-Viciana. (2019) SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics. Proceedings of the National Academy of Sciences 116:27, pages 13330-13339.
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HyeIn Jang, Eun Ryoung Jang, Patricia G. Wilson, Daniel Anderson & Emilia Galperin. (2019) VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology. Molecular Biology of the Cell 30:14, pages 1655-1663.
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Simona Gallo, Annapia Vitacolonna, Alessandro Bonzano, Paolo Comoglio & Tiziana Crepaldi. (2019) ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy. International Journal of Molecular Sciences 20:9, pages 2164.
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HyeIn Jang, Erin Oakley, Marie Forbes-Osborne, Melissa V Kesler, Rebecca Norcross, Ann C Morris & Emilia Galperin. (2019) Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome . Human Molecular Genetics 28:3, pages 501-514.
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Huang Xiao-pei, Chen Ji-kuai, Wei Xue, Yi-Fan Dong, Lang Yan, Zhang Xiao-fang, Pan Ya-min, Chang Wen-jun & Zhu Jiang-bo. (2018) Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol. Bioscience Reports 38:6.
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Mylène Tajan, Romain Paccoud, Sophie Branka, Thomas Edouard & Armelle Yart. (2018) The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway. Endocrine Reviews 39:5, pages 676-700.
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Julien M.D. Legrand, Edwige Roy, Batoul Baz, Pamela Mukhopadhyay, Ho Yi Wong, Ramesh Ram, Grant Morahan, Graeme Walker & Kiarash Khosrotehrani. (2018) Genetic variation in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway affects contact hypersensitivity responses. Journal of Allergy and Clinical Immunology 142:3, pages 981-984.e7.
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