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Communicative & Integrative Biology Volume 10, 2017 - Issue 3
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Research Paper

Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis

Emily PitcairnDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USA
,
Hannah HarrisDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USA
,
Justine EpineyDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USA
,
Vaibhav P. PaiDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USA
,
Joan M. LemireDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USA
,
Bin YeDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA
,
Nian-Qing ShiDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA
,
Michael LevinDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USAORCID Iconhttp://orcid.org/0000-0001-7292-8084
ORCID Icon &
Kelly A. McLaughlinDepartment of Biology and Allen Discovery Center at Tufts University, Medford, MA, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2541-2189
ORCID Icon show all
Article: e1309488 | Received 16 Mar 2017, Accepted 16 Mar 2017, Published online: 10 May 2017

Citations (26)

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Xiao-Hong Li, Ya-Min Hu, Guang-Li Yin & Ping Wu. (2019) Correlation between HCN4 gene polymorphisms and lone atrial fibrillation risk. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 2989-2993.
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Articles from other publishers (25)

Santosh Manicka, Vaibhav P. Pai & Michael Levin. (2023) Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain. iScience 26:12, pages 108398.
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Elizabeth E. Blue, Janson J. White, Michael K. Dush, William W. Gordon, Brent H. Wyatt, Peter White, Colby T. Marvin, Emmi Helle, Tiina Ojala, James R. Priest, Mary M. Jenkins, Lynn M. Almli, Jennita Reefhuis, Faith Pangilinan, Lawrence C. Brody, Kim L. McBride, Vidu Garg, Gary M. Shaw, Paul A. Romitti, Wendy N. Nembhard, Marilyn L. Browne, Martha M. Werler, Denise M. Kay, Seema Mital, Jessica X. Chong, Nanette M. Nascone-Yoder & Michael J. Bamshad. (2023) Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome. Human Genetics and Genomics Advances 4:4, pages 100232.
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E. A. Lebedeva & M. A. Gonotkov. (2023) Resistance of Embryonic Chick Atria to Inhibition of HCN-Channels and Components of the “Ca2+-Clock”. Journal of Evolutionary Biochemistry and Physiology 59:4, pages 1452-1458.
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Joao Carvalho. (2023) A computational model of cell membrane bioelectric polarization and depolarization, connected with cell proliferation, in different tissue geometries. Journal of Theoretical Biology 557, pages 111338.
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Vaibhav P. Pai & Michael Levin. (2022) HCN2 channel‐induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling. Wound Repair and Regeneration 30:6, pages 681-706.
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Jiaying Liu, Go Kasuya, Buntaro Zempo & Koichi Nakajo. (2022) Two HCN4 Channels Play Functional Roles in the Zebrafish Heart. Frontiers in Physiology 13.
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Joao Carvalho. (2022) A computational model of organism development and carcinogenesis resulting from cells’ bioelectric properties and communication. Scientific Reports 12:1.
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Michael Levin. (2022) Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds. Frontiers in Systems Neuroscience 16.
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Héctor O. Rodríguez-Angulo, Diana Colombet-Naranjo, María C. Maza, Cristina Poveda, Alfonso Herreros-Cabello, Iván Mendoza, Juan C. Perera, Juan D. Goyo, Núria Gironès & Manuel Fresno. (2021) Molecular Remodeling of Cardiac Sinus Node Associated with Acute Chagas Disease Myocarditis. Microorganisms 9:11, pages 2208.
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Patrizia Benzoni, Giorgia Bertoli, Federica Giannetti, Chiara Piantoni, Raffaella Milanesi, Matteo Pecchiari, Andrea Barbuti, Mirko Baruscotti & Annalisa Bucchi. (2021) The funny current: Even funnier than 40 years ago. Uncanonical expression and roles of HCN/f channels all over the body. Progress in Biophysics and Molecular Biology.
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Joao Carvalho. (2021) A bioelectric model of carcinogenesis, including propagation of cell membrane depolarization and reversal therapies. Scientific Reports 11:1.
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Michael Levin. (2021) Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer. Cell 184:8, pages 1971-1989.
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Alena CasellaAlyssa PanitchJ. Kent Leach. (2021) Endogenous Electric Signaling as a Blueprint for Conductive Materials in Tissue Engineering. Bioelectricity 3:1, pages 27-41.
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Pranjal SrivastavaAnna KaneChristina HarrisonMichael Levin. (2021) A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration. Bioelectricity 3:1, pages 42-67.
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Marc-André Legault, Johanna Sandoval, Sylvie Provost, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Sonia Shah, R. Thomas Lumbers, Simon de Denus, Benoit Tyl, Jean-Claude Tardif & Marie-Pierre Dubé. (2020) A genetic model of ivabradine recapitulates results from randomized clinical trials. PLOS ONE 15:7, pages e0236193.
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Vaibhav P. Pai, Javier Cervera, Salvador Mafe, Valerie Willocq, Emma K. Lederer & Michael Levin. (2020) HCN2 Channel-Induced Rescue of Brain Teratogenesis via Local and Long-Range Bioelectric Repair. Frontiers in Cellular Neuroscience 14.
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Angela Tung & Michael Levin. (2020) Extra-genomic instructive influences in morphogenesis: A review of external signals that regulate growth and form. Developmental Biology 461:1, pages 1-12.
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Patrick McMillen, Richard Novak & Michael Levin. (2020) Toward Decoding Bioelectric Events in Xenopus Embryogenesis: New Methodology for Tracking Interplay Between Calcium and Resting Potentials In Vivo. Journal of Molecular Biology 432:2, pages 605-620.
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Santosh Manicka & Michael Levin. (2019) Modeling somatic computation with non-neural bioelectric networks. Scientific Reports 9:1.
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Michael Levin, John Selberg & Marco Rolandi. (2019) Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine. iScience 22, pages 519-533.
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Pessah Yampolsky, Michael Koenen, Matias Mosqueira, Pascal Geschwill, Sebastian Nauck, Monika Witzenberger, Claudia Seyler, Thomas Fink, Mathieu Kruska, Claus Bruehl, Alexander P. Schwoerer, Heimo Ehmke, Rainer H. A. Fink, Andreas Draguhn, Dierk Thomas, Hugo A. Katus & Patrick A. Schweizer. (2019) Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling. Nature Communications 10:1.
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Javier Cervera, Alexis Pietak, Michael Levin & Salvador Mafe. (2018) Bioelectrical coupling in multicellular domains regulated by gap junctions: A conceptual approach. Bioelectrochemistry 123, pages 45-61.
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Vaibhav P. Pai, Alexis Pietak, Valerie Willocq, Bin Ye, Nian-Qing Shi & Michael Levin. (2018) HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns. Nature Communications 9:1.
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Kelly A. McLaughlin & Michael Levin. (2018) Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form. Developmental Biology 433:2, pages 177-189.
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Vaibhav P. Pai, Valerie Willocq, Emily J. Pitcairn, Joan M. Lemire, Jean-François Paré, Nian-Qing Shi, Kelly A. McLaughlin & Michael Levin. (2017) HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a Nodal- and Lefty asymmetric gene expression-independent manner. Biology Open.
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