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Original Articles

Detection of hazardous weight-loss substances in adulterated slimming formulations using ultra-high-pressure liquid chromatography with diode-array detection

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Pages 161-171 | Received 01 Sep 2011, Accepted 02 Nov 2011, Published online: 09 Dec 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Samin Hamidi. (2023) Assessment of Undeclared Synthetic Drugs in Dietary Supplements in an Analytical View: A Comprehensive Review. Critical Reviews in Analytical Chemistry 53:5, pages 986-996.
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Walaa Ahmed Khairy, Hebatallah A Nasser, Mai D Sarhan, Aliaa Ali El Shamy & Yasmine Samir Galal. (2021) Prevalence and Predictors of Self-Medication with Antifungal Drugs and Herbal Products Among University Students: A Cross-Sectional Study from Egypt. Risk Management and Healthcare Policy 14, pages 2191-2200.
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P. Girish, M. Jayanthi, B. Gitanjali, S. Manikandan & S. Rajan. (2021) Screening of Weight-Loss Herbal Products for Synthetic Anti-Obesity Adulterants: A Target-Oriented Analysis by Liquid Chromatography–Tandem Mass Spectrometry. Journal of Dietary Supplements 18:1, pages 92-104.
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Akihiko Nakamura, Takaomi Tagami, Keiji Kajimura, Katsuhiro Yamasaki, Yoshiyuki Sawabe & Hirotaka Obana. (2016) Simultaneous analysis of highly polar pharmaceutical adulterants in slimming products by hydrophilic interaction liquid chromatography. Journal of Liquid Chromatography & Related Technologies 39:15, pages 691-697.
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Caroline Mathon, Anita Ankli, Eike Reich, Stefan Bieri & Philippe Christen. (2014) Screening and determination of sibutramine in adulterated herbal slimming supplements by HPTLC-UV densitometry. Food Additives & Contaminants: Part A 31:1, pages 15-20.
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Ji Won Kim, Soon Jae Kweon, Seon Kyung Park, Jung Yeon Kim, Ji Hyun Lee, Kyoung Moon Han, Sooyeul Cho, Jinho Kim, Soon Young Han, Hyoung Ja Kim & Woo Seong Kim. (2013) Isolation and identification of a sibutramine analogue adulterated in slimming dietary supplements. Food Additives & Contaminants: Part A 30:7, pages 1221-1229.
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Articles from other publishers (44)

Shijia Jiang, Junbo Zhao, Hui Yan, Ping Xiang & Min Shen. (2023) Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry. Analytical Methods 15:35, pages 4434-4441.
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Mengwei Jia, Huihui Gu, Yongling Lu & Lishuang Lv. (2023) Effects of hesperidin combined with synephrine on the capture of acrolein in a mouse model, or in humans by citrus consumption. Food & Function 14:11, pages 5417-5428.
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Qian Wang, Yu Bian, Yuan Zhang, De-mei Sun, Wei-lai Wang, Yu Zhou, Zhi-fei Liu, Xue-song Feng & Zhen-wei He. (2023) Development of sampling, pretreatment and detection methods for ephedrine and related substances in complex samples. Microchemical Journal 189, pages 108538.
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Noha F. El Azab, Sarah H. Abdelaal, Said A. Hassan & Amira M. El-Kosasy. (2022) Dietary supplement mislabelling: case study on selected slimming products by developing a green isocratic HPLC method for their quality control. Scientific Reports 12:1.
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João V.M. de Almeida, Lucas M. Berneira, Taís Polleti, Igor F. Santa Barbara, Natalia L. Goulart & Claudio M.P. de Pereira. (2022) Optimization and development of novel green extraction methods applied to apprehended slimming agents containing mazindol. Talanta Open 6, pages 100165.
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Ali Akbar Asgharinezhad, Saeed Hejabri Kandeh & Homeira Ebrahimzadeh. (2022) Polypyrrole-polyaniline nanorods assisted electromembrane extraction of phenolphthalein from herbal slimming products prior to its determination by the liquid chromatography method. Microchemical Journal 183, pages 108102.
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Ensie Hosseini, Jahan B Ghasemi & Maryam Shekarchi. (2022) Simultaneous Determination of Adulterants in Dietary Food Supplements Using Multivariate Data Analysis after Preconcentration with Novel Nanosorbents and Chromatographic Measurement. Journal of AOAC INTERNATIONAL 105:5, pages 1309-1318.
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Zoran Zhivikj, Marija Karapandzova, Katerina Brezovska, Tanja Petreska Ivanovska, Ivana Cvetkovikj Karanfilova, Gjoshe Stefkov, Lidija Petrushevska-Tozi & Svetlana Kulevanova. (2022) Validation of HPLC-DAD method for analysis of sibutramine, fluoxetine, caffeine, theobromine and phenolphthalein as potential adulterants in weight loss dietary supplements. Macedonian Pharmaceutical Bulletin 66:04, pages 33-34.
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Ammar A. Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan & Sa’ed H. Zyoud. (2021) Adulteration of Weight Loss Supplements by the Illegal Addition of Synthetic Pharmaceuticals. Molecules 26:22, pages 6903.
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Justyna Brzezicha, Daria Błażejewicz, Joanna Brzezińska & Małgorzata Grembecka. (2021) Green coffee VS dietary supplements: A comparative analysis of bioactive compounds and antioxidant activity. Food and Chemical Toxicology 155, pages 112377.
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Yingying Li, Haihuan Xie, Jin Wang, Xiangmei Li, Zhili Xiao, Zhenlin Xu, Hongtao Lei & Xing Shen. (2021) Lateral Flow Immunochromatography Assay for Detection of Furosemide in Slimming Health Foods. Foods 10:9, pages 2041.
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Julia Rodrigues Martins Pastor dos Santos, Jorge Guerra Mendes Junior, André Luis Mazzei Albert & Katia Christina Leandro. (2021) Rapid Screening Method in the Identification of 17 Adulterants in Dietary Supplements. Chromatographia 84:3, pages 267-274.
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Niloofar Jalilian, Homeira Ebrahimzadeh, Ali Akbar Asgharinezhad & Parisa Khodayari. (2021) Magnetic molecularly imprinted polymer for the selective dispersive micro solid phase extraction of phenolphthalein in urine samples and herbal slimming capsules prior to HPLC-PDA analysis. Microchemical Journal 160, pages 105712.
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Alexandra Figueiredo, Isabel Margarida Costa, Tânia Alexandra Fernandes, Luísa Lima Gonçalves & José Brito. (2020) Food Supplements for Weight Loss: Risk Assessment of Selected Impurities. Nutrients 12:4, pages 954.
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Nao Wu, Stéphane Balayssac, Saïda Danoun, Myriam Malet-Martino & Véronique Gilard. (2020) Chemometric Analysis of Low-field 1H NMR Spectra for Unveiling Adulteration of Slimming Dietary Supplements by Pharmaceutical Compounds. Molecules 25:5, pages 1193.
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Ji Hyun Lee, Han Na Park, Nam Sook Kim, Seongsoo Park, Ganganna Bogonda, Kyungsoo Oh & Hoil Kang. (2019) Application of screening methods for weight-loss compounds and identification of new impurities in counterfeit drugs. Forensic Science International 303, pages 109932.
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Bharathi Avula, Ji-Yeong Bae, Amar G. Chittiboyina, Yan-Hong Wang, Mei Wang & Ikhlas A. Khan. (2019) Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements. Journal of Pharmaceutical and Biomedical Analysis 174, pages 305-323.
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Samantha C. de Freitas, Marco A.Z. dos Santos, Lucas M. Berneira, Rafael S. Ortiz & Claudio M.P. de Pereira. (2019) Microwave-assisted extraction and differential scanning calorimetry in the chemical identification of sliming agents apprehended in the south region of Brazil. Science & Justice 59:2, pages 190-198.
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Nada Ahmed, Mohamed Ismail Nounou, Alaa Abouelfetouh & Amal El-Kamel. (2019) Over-the-Counter Herbal Weight Loss Supplements in Egypt: Label Claim, Microbiological and Pharmaceutical Quality, and Safety Assessments. Medical Principles and Practice 28:2, pages 167-177.
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Nam-Yong Ki, Jisu Hur, Beom Hee Kim, Kyung Ho Kim, Bong Jin Moon, Han Bin Oh & Jongki Hong. (2019) Rapid screening of sulfonamides in dietary supplements based on extracted common ion chromatogram and neutral loss scan by LC-Q/TOF-mass spectrometry. Journal of Food and Drug Analysis 27:1, pages 164-174.
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Ying Shi, Yanqin Zhong, Aimin Sun, Bo Gao, Chengjun Sun & Jingyuan Xiong. (2018) Validation of a rapid and simple high-performance liquid chromatography-electrospray ionization-mass spectrometry method for simultaneous analysis of 15 key chemicals in slimming foods and herbal products. Journal of Chromatographic Science.
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Hervé Rebiere, Pauline Guinot, Denis Chauvey & Charlotte Brenier. (2017) Fighting falsified medicines: The analytical approach. Journal of Pharmaceutical and Biomedical Analysis 142, pages 286-306.
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Nur Cebi, Mustafa Tahsin Yilmaz & Osman Sagdic. (2017) A rapid ATR-FTIR spectroscopic method for detection of sibutramine adulteration in tea and coffee based on hierarchical cluster and principal component analyses. Food Chemistry 229, pages 517-526.
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Alexandru Robert Vlad, Gabriel Hancu, Hajnal Kelemen, Diana Ciurcă & Amelia Tero-Vescan. (2017) Analytical Methodologies for the Stereoselective Determination of Sibutramine: An Overview. Acta Medica Marisiensis 63:2, pages 52-55.
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D. Custers, E. Van Hoeck, P. Courselle, S. Apers & E. Deconinck. (2017) Clustering and diagnostic modelling of slimming aids based on chromatographic and mass spectrometric fingerprints. Drug Testing and Analysis 9:2, pages 230-242.
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Deborah Custers, Patricia Courselle, Sandra Apers & Eric Deconinck. (2016) Chemometrical analysis of fingerprints for the detection of counterfeit and falsified medicines. Reviews in Analytical Chemistry 35:4, pages 145-168.
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Tiago Rocha, Joana S. Amaral & Maria Beatriz P.P. Oliveira. (2016) Adulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: A Review. Comprehensive Reviews in Food Science and Food Safety 15:1, pages 43-62.
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Ana Paula L. Moreira, Mariele Martini & Leandro M. de Carvalho. (2014) Capillary electrophoretic methods for the screening and determination of pharmacologic adulterants in herbal‐based pharmaceutical formulations. ELECTROPHORESIS 35:21-22, pages 3212-3230.
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Mirosław Krośniak, Renata Francik, Agnieszka Wojtanowska-Krośniak, Cinzia Tedeschi, Małgorzata Krasoń-Nowak, Joanna Chłopicka & Ryszard Gryboś. (2014) Vanadium Methyl-Bipyridine Organoligand and its Influence on Energy Balance and Organs Mass. Biological Trace Element Research 160:3, pages 376-382.
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Jianhui Li, Zhaohui Zhang, Xin Liu, Hua Yan, Shen Han, Haiyan Zhang, Shan Zhang & Jia Cheng. (2013) Analysis of Fourteen β-Agonists in Weight-Reducing Dietary Supplements Using QuEChERS-Based Extraction Followed by High Resolution UHPLC-MS. Food Analytical Methods 7:5, pages 977-985.
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Constantinos K. Zacharis, Fotini S. Kika, Paraskevas D. Tzanavaras & Konstantinos Fytianos. (2013) Development and validation of a rapid ultra high pressure liquid chromatographic method for the determination of methylxanthines in herbal infusions. Journal of Chromatography B 927, pages 218-222.
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Noha F. El Azab, Sarah H. Abdelaal, said Hassan & Amira M. El-Kosasy. (2022) Dietary Supplement Mislabelling: A Case Study on Selected Slimming Products by Developing a Green Isocratic Hplc Method for Their Quality Control. SSRN Electronic Journal.
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