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Food Additives & Contaminants: Part A Volume 31, 2014 - Issue 1
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Original Articles

Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product

Kyoung Moon HanAdvanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, Korea
,
Ji Hyun LeeAdvanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, Korea
,
Hyoung-Joon ParkAdvanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, Korea
,
Insun HwangAdvanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, Korea
,
Ok-Soon HeoAdvanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, Korea
&
Woo Seong KimAdvanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongwon-gun, KoreaCorrespondence[email protected]
Pages 1-6 | Received 26 Jul 2013, Accepted 12 Oct 2013, Published online: 02 Jan 2014

Citations (18)

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Chee-Leong Kee, Xiaowei Ge, Min-Yong Low, Véronique Gilard & Myriam Malet-Martino. (2023) Analytical methods for the detection and characterization of unapproved phosphodiesterase type 5 inhibitors (PDE-5i) used in adulteration of dietary supplements- a review. Food Additives & Contaminants: Part A 0:0, pages 1-36.
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Pengfei Jin, Shuo Xu, Wenfeng Xu, Xiaorong He, Yongmei Kuang & Xin Hu. (2020) Screening and quantification of fourteen synthetic antidiabetic adulterants in herbal pharmaceuticals and health foods by HPLC and confirmation by LC-Q-TOF-MS/MS. Food Additives & Contaminants: Part A 37:1, pages 11-18.
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Ji Hye Jeong, Ji Hyun Lee, Hyung Joo Kim, Hyoung Joon Park, In Sun Hwang, Kyoung Moon Han, Chang-Yong Yoon, Sooyeul Cho & Woo Seong Kim. (2016) LC-ESI-MS/MS analysis of phosphodiesterase-5 inhibitors and their analogues in foods and dietary supplements in Korea. Food Additives & Contaminants: Part B 9:1, pages 1-8.
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Chee-Leong Kee, Xiaowei Ge & Min-Yong Low. (2015) Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements. Food Additives & Contaminants: Part A 32:10, pages 1737-1748.
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Articles from other publishers (14)

Ning Yu, Jianxun Han, Tingting Deng, Liping Chen, Jiukai Zhang, Ranran Xing, Ping Wang, Guiming Zhao & Ying Chen. (2020) A Novel Analytical Droplet Digital PCR Method for Identification and Quantification of Raw Health Food Material Powder from Panax notoginseng. Food Analytical Methods 14:3, pages 552-560.
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Ji Hyun Lee, Han Na Park, Seongsoo Park, Yong-Moon Lee & Hoil Kang. (2019) Development of a specific fragment pattern-based quadrupole-Orbitrap mass spectrometry method to screen adulterated products of phosphodiesterase-5 inhibitors and their analogues. Science & Justice 59:4, pages 433-441.
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Ji Hyun Lee, Han Na Park, Ok Rim Park, Nam Sook Kim, Sung-Kwan Park & Hoil Kang. (2019) Screening of illegal sexual enhancement supplements and counterfeit drugs sold in the online and offline markets between 2014 and 2017. Forensic Science International 298, pages 10-19.
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Ji Hyun Lee, Han Na Park, Aeran Jung, Suresh Mandava, Seongsoo Park, Jongkook Lee & Hoil Kang. (2018) Isolation and characterisation of a novel sildenafil analogue adulterant, desmethylpiperazinyl propoxysildenafil, in a dietary supplement. Science & Justice 58:6, pages 447-454.
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Miho Sakamoto, Jin Suzuki, Yuri Saito, Seiko Shimizu, Kazue Kobayashi, Machiko Nagashima, Takako Moriyasu, Haruhiko Fukaya & Koichi Saito. (2018) Structural characterization of dimethyldithiodenafil and dimethylthiocarbodenafil, analogs of sildenafil. Journal of Pharmaceutical and Biomedical Analysis 148, pages 136-141.
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Chee-Leong Kee, Xiaowei Ge, Véronique Gilard, Myriam Malet-Martino & Min-Yong Low. (2018) A review of synthetic phosphodiesterase type 5 inhibitors (PDE-5i) found as adulterants in dietary supplements. Journal of Pharmaceutical and Biomedical Analysis 147, pages 250-277.
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Sara E. Kern, Lisa M. Lorenz, Adam Lanzarotta, Elisa A. Nickum & Jonathan J. Litzau. (2016) Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement. Journal of Pharmaceutical and Biomedical Analysis 128, pages 360-366.
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Ji Hyun Lee, Suresh Mandava, Sun Young Baek & Yong-Moon Lee. (2016) Identification and structural elucidation of three new tadalafil analogues found in a dietary supplement. Journal of Pharmaceutical and Biomedical Analysis 123, pages 1-9.
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Yimin Xu, Chee-Leong Kee, Xiaowei Ge, Min-Yong Low & Hwee-Ling Koh. (2016) Isolation and characterization of a tadalafil analogue, N -cyclopentyl nortadalafil in health supplement. Journal of Pharmaceutical and Biomedical Analysis 118, pages 235-241.
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X. Ge, C.-L. Kee, Y. Zeng & M.-Y. Low. 2016. Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis. Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis 155 197 .
Razieh Karimi Aghcheh & Christian P. Kubicek. (2015) Epigenetics as an emerging tool for improvement of fungal strains used in biotechnology. Applied Microbiology and Biotechnology 99:15, pages 6167-6181.
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Hongbo Li, Qingshan Shen, Wei Zhou, Haizhen Mo, Daodong Pan & Liangbin Hu. (2015) Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus. Molecules 20:4, pages 6022-6032.
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Ji Hyun Lee, Hyung Joo Kim, Eunyoung Noh, Jung Yeon Kim, So Hyun Cho, Jung-Ah Do, Chang-Yong Yoon, Sooyeul Cho & Woo Seong Kim. (2015) Identification and screening of a tadalafil analogue found in adulterated herbal products. Journal of Pharmaceutical and Biomedical Analysis 103, pages 80-84.
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Chee-Leong Kee, Hwee-Ling Koh, Bosco Chen Bloodworth, Yun Zeng, Kin-Har Kiang, Min-Yong Low & Xiaowei Ge. (2014) Structural elucidation of propoxyphenyl isobutyl aildenafil, adulterant in a health supplement using high-resolution Orbitrap mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 98, pages 153-159.
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