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Original Articles

Influence of temperature and pH on the degradation of deoxynivalenol (DON) in aqueous medium: comparative cytotoxicity of DON and degraded product

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Pages 121-131 | Received 08 Jul 2013, Accepted 28 Oct 2013, Published online: 14 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ehsan Feizollahi & M. S. Roopesh. (2022) Mechanisms of deoxynivalenol (DON) degradation during different treatments: a review. Critical Reviews in Food Science and Nutrition 62:21, pages 5903-5924.
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Sakshi Mishra, Sonal Srivastava, Jayant Dewangan, Aman Divakar & Srikanta Kumar Rath. (2020) Global occurrence of deoxynivalenol in food commodities and exposure risk assessment in humans in the last decade: a survey. Critical Reviews in Food Science and Nutrition 60:8, pages 1346-1374.
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Arnau Vidal, Vicente Sanchis, Antonio J. Ramos & Sonia Marín. (2018) Stability of DON and DON-3-glucoside during baking as affected by the presence of food additives. Food Additives & Contaminants: Part A 35:3, pages 529-537.
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Taeyong Eom, Hyun-Deok Cho, Junghyun Kim, Mihee Park, Jinyoung An, Moosung Kim, Sheen-Hee Kim & Sang Beom Han. (2017) Multiclass mycotoxin analysis in edible oils using a simple solvent extraction method and liquid chromatography with tandem mass spectrometry. Food Additives & Contaminants: Part A 34:11, pages 2011-2022.
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Articles from other publishers (36)

Prakash Sumalatha & Pavagada K. Maheshwar. 2024. Anti‐Mycotoxin Strategies for Food and Feed. Anti‐Mycotoxin Strategies for Food and Feed 177 199 .
Yulei Zhang, Binbin Ouyang, Wenli Zhang, Cuie Guang, Wei Xu & Wanmeng Mu. (2024) Deoxynivalenol: Occurrence, toxicity, and degradation. Food Control 155, pages 110027.
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Jung-Ah Shin & Ki-Teak Lee. (2023) Migration Degree of Selected Mycotoxins in the Distillation Process and Their Determination in Distilled Spirits from Pilot-Scale Continuous Distillation. Foods 12:23, pages 4189.
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Ehsan Feizollahi, Brasathe Jeganathan, Béla Reiz, Thavaratnam Vasanthan & M.S. Roopesh. (2023) Reduction of deoxynivalenol during barley steeping in malting using plasma activated water and the determination of major degradation products. Journal of Food Engineering 352, pages 111525.
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Xiaolong Wang, Shanrui Li, Lian Li, Yunhan Ding, Tianao Xu, Jun Liu, Quanxin Li, Tong Zhao & Yuantao Zhang. (2023) Mycotoxins degradation by reactive oxygen species in plasma: Reactive molecular dynamics insights. LWT 184, pages 115058.
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Ruifen Kang, Honglei Qu, Yanxin Guo, Chuanliang Ji, Jie Cheng, Yantao Wang, Shimeng Huang, Lihong Zhao, Cheng Ji & Qiugang Ma. (2023) Toxicokinetics of Deoxynivalenol in Dezhou Male Donkeys after Oral Administration. Toxins 15:7, pages 426.
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Hong Lei, Shenghu Zhu, Chang Liu, Wei Zhang, Chong Chen & Hui Yan. (2023) Constructing the Au nanoparticle multimer on optical fiber end face to enhance the signal of localized surface plasmon resonance biosensors: A case study for deoxynivalenol detection. Sensors and Actuators B: Chemical 380, pages 133380.
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Liu-Nan Yang, Shiyin Xu, Mingmeng Tang, Xiaolei Zhou, Yuxiao Liao, Andreas K. Nüssler, Liegang Liu & Wei Yang. (2023) The circadian rhythm gene Bmal1 ameliorates acute deoxynivalenol-induced liver damage. Archives of Toxicology 97:3, pages 787-804.
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Ehsan Feizollahi, Urmila Basu, Rudolph Fredua-Agyeman, Brasathe Jeganathan, Lusine Tonoyan, Stephen E. Strelkov, Thava Vasanthan, Arno G. Siraki & M. S. Roopesh. (2023) Effect of Plasma-Activated Water Bubbles on Fusarium graminearum, Deoxynivalenol, and Germination of Naturally Infected Barley during Steeping. Toxins 15:2, pages 124.
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Zhaojian Li, Yahui Zhao, Qiufang Zong, Ping Hu, Wenbin Bao, Hao-Yu Liu & Demin Cai. (2023) Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood–Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response. Antioxidants 12:1, pages 152.
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Shanrui Li, Xiaolong Wang, Lian Li, Jun Liu, Yunhan Ding, Tong Zhao & Yuantao Zhang. (2022) Atomic-scale simulations of the deoxynivalenol degradation induced by reactive oxygen plasma species. Food Research International 162, pages 111939.
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Liesel Claeys, Sarah De Saeger, Ghislaine Scelo, Carine Biessy, Corinne Casagrande, Genevieve Nicolas, Michael Korenjak, Beatrice Fervers, Alicia K. Heath, Vittorio Krogh, Leila Luján-Barroso, Jesús Castilla, Börje Ljungberg, Miguel Rodriguez-Barranco, Ulrika Ericson, Carmen Santiuste, Alberto Catalano, Kim Overvad, Magritt Brustad, Marc J. Gunter, Jiri Zavadil, Marthe De Boevre & Inge Huybrechts. (2022) Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. Nutrients 14:17, pages 3581.
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Antonio Gallo, Martina Mosconi, Erminio Trevisi & Regiane R. Santos. (2022) Adverse Effects of Fusarium Toxins in Ruminants: A Review of In Vivo and In Vitro Studies. Dairy 3:3, pages 474-499.
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Fengjiang Sun, Beibei Lv, Xuemeng Zhang, Chenyu Wang, Liyuan Zhang, Xiaochen Chen, Yuancun Liang, Lei Chen, Shenshen Zou & Hansong Dong. (2022) The Endoplasmic Reticulum Cargo Receptor FgErv14 Regulates DON Production, Growth and Virulence in Fusarium graminearum. Life 12:6, pages 799.
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Xiangyi Meng, Wenyan Yu, Nuo Duan, Zhouping Wang, Yingbin Shen & Shijia Wu. (2022) Protective Effects of Ferulic Acid on Deoxynivalenol-Induced Toxicity in IPEC-J2 Cells. Toxins 14:4, pages 275.
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J.R. GerezA.L.P.L. GomesR.P. ErthalG.S.A. FernandesR.L.N. MatosW.A. VerriJr.Jr., E.M. GloriaA.P.F.R.L. Bracarense. (2021) Effects of deoxynivalenol exposure at peripuberty over testicles of rats: structural and functional alterations. World Mycotoxin Journal 14:3, pages 431-440.
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Zhiwei Ying, Di Zhao, He Li, Xinqi Liu & Jian Zhang. (2021) Efficient Adsorption of Deoxynivalenol by Porous Carbon Prepared from Soybean Dreg. Toxins 13:7, pages 500.
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Changning Yu, Peng Lu, Shangxi Liu, Qiao Li, Erhua Xu, Joshua Gong, Song Liu & Chengbo Yang. (2021) Efficiency of Deoxynivalenol Detoxification by Microencapsulated Sodium Metabisulfite Assessed via an In Vitro Bioassay Based on Intestinal Porcine Epithelial Cells . ACS Omega 6:12, pages 8382-8393.
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Hongrong Long, Zhongquan Xin, Fan Zhang, Zhenya Zhai, Xiaojun Ni, Jialuo Chen, Kang Yang, Pinfeng Liao, Limeng Zhang, Zaili Xiao, Daniel Sindaye & Baichuan Deng. (2021) The cytoprotective effects of dihydromyricetin and associated metabolic pathway changes on deoxynivalenol treated IPEC-J2 cells. Food Chemistry 338, pages 128116.
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Zhao Peng, Yuxiao Liao, Xiaoqian Wang, Liangkai Chen, Liangliang Wang, Chenyuan Qin, Zhenting Wang, Mengyao Cai, Jiawei Hu, Dan Li, Ping Yao, Andreas K. Nüssler, Liegang Liu & Wei Yang. (2019) Heme oxygenase-1 regulates autophagy through carbon–oxygen to alleviate deoxynivalenol-induced hepatic damage. Archives of Toxicology 94:2, pages 573-588.
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Dongliang Ren, Enjie Diao, Hanxue Hou & Haizhou Dong. (2020) Degradation and ozonolysis pathway elucidation of deoxynivalenol. Toxicon 174, pages 13-18.
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You Zhou, Shijia Wu, Fang Wang, Qian Li, Chuxian He, Nuo Duan & Zhouping Wang. (2020) Assessing the toxicity in vitro of degradation products from deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO2 composite. Chemosphere 238, pages 124648.
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Zhao Peng, Yuxiao Liao, Liangkai Chen, Shuang Liu, Zhilei Shan, Andreas K. Nüssler, Ping Yao, Hong Yan, Liegang Liu & Wei Yang. (2019) Heme oxygenase-1 attenuates low-dose of deoxynivalenol-induced liver inflammation potentially associating with microbiota. Toxicology and Applied Pharmacology 374, pages 20-31.
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Mahsa Hallaj Salahipour, Shapour Hasanzadeh, Hassan Malekinejad, Mazdak Razi & Farhad Farrokhi‐Ardebili. (2019) Deoxynivalenol reduces quality parameters and increases DNA damage in mice spermatozoa. Andrologia 51:5, pages e13238.
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Rui Qu, Chunmei Jiang, Wanqin Wu, Bing Pang, Shuzhen Lei, Ziyang Lian, Dongyan Shao, Mingliang Jin & Junling Shi. (2019) Conversion of DON to 3- epi -DON in vitro and toxicity reduction of DON in vivo by Lactobacillus rhamnosus . Food & Function 10:5, pages 2785-2796.
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Dominika Ewa Habrowska-Górczyńska, Karolina Kowalska, Kinga Anna Urbanek, Kamila Domińska, Agata Sakowicz & Agnieszka Wanda Piastowska-Ciesielska. (2019) Deoxynivalenol Modulates the Viability, ROS Production and Apoptosis in Prostate Cancer Cells. Toxins 11:5, pages 265.
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David Stadler, Francesca Lambertini, Christoph Bueschl, Gerlinde Wiesenberger, Christian Hametner, Heidi Schwartz-Zimmermann, Roland Hellinger, Michael Sulyok, Marc Lemmens, Rainer Schuhmacher, Michele Suman, Franz Berthiller & Rudolf Krska. (2019) Untargeted LC–MS based 13C labelling provides a full mass balance of deoxynivalenol and its degradation products formed during baking of crackers, biscuits and bread. Food Chemistry 279, pages 303-311.
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Dongjie Chen, Paul Chen, Yanling Cheng, Peng Peng, Juer Liu, Yiwei Ma, Yuhuan Liu & Roger Ruan. (2018) Deoxynivalenol Decontamination in Raw and Germinating Barley Treated by Plasma-Activated Water and Intense Pulsed Light. Food and Bioprocess Technology 12:2, pages 246-254.
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Kinga Anna Urbanek, Dominika Ewa Habrowska-Górczyńska, Karolina Kowalska, Anna Stańczyk, Kamila Domińska & Agnieszka Wanda Piastowska-Ciesielska. (2018) Deoxynivalenol as potential modulator of human steroidogenesis. Journal of Applied Toxicology 38:12, pages 1450-1459.
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Payal Mandal, Ankita Rai, Sakshi Mishra, Anurag Tripathi & Mukul Das. 2018. Mutagenicity: Assays and Applications. Mutagenicity: Assays and Applications 133 160 .
Elisabeth Mayer, Barbara Novak, Alexandra Springler, Heidi E. Schwartz-Zimmermann, Veronika Nagl, Nicole Reisinger, Sabine Hessenberger & Gerd Schatzmayr. (2017) Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line. Mycotoxin Research 33:4, pages 297-308.
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Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather Wallace, Sarah De Saeger, Gunnar Sundstøl Eriksen, Peter Farmer, Jean‐Marc Fremy, Yun Yun Gong, Karsten Meyer, Hanspeter Naegeli, Dominique Parent‐Massin, Ivonne Rietjens, Hans van Egmond, Andrea Altieri, Mari Eskola, Petra Gergelova, Luisa Ramos Bordajandi, Bistra Benkova, Barbara Dörr, Athanasios Gkrillas, Nicklas Gustavsson, Mathijs van Manen & Lutz Edler. (2017) Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA Journal 15:9.
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Xiaojuan Bai, Changpo Sun, Di Liu, Xiaohong Luo, Di Li, Jun Wang, Nanxi Wang, Xiaojiao Chang, Ruilong Zong & Yongfa Zhu. (2017) Photocatalytic degradation of deoxynivalenol using graphene/ZnO hybrids in aqueous suspension. Applied Catalysis B: Environmental 204, pages 11-20.
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Alexandra Springler, Sabine Hessenberger, Gerd Schatzmayr & Elisabeth Mayer. (2016) Early Activation of MAPK p44/42 Is Partially Involved in DON-Induced Disruption of the Intestinal Barrier Function and Tight Junction Network. Toxins 8:9, pages 264.
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Arnau Vidal, Jordi Bendicho, Vicente Sanchis, Antonio J. Ramos & Sonia Marín. (2016) Stability and kinetics of leaching of deoxynivalenol, deoxynivalenol-3-glucoside and ochratoxin A during boiling of wheat spaghettis. Food Research International 85, pages 182-190.
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Veronika Nagl & Gerd Schatzmayr. (2015) Deoxynivalenol and its masked forms in food and feed. Current Opinion in Food Science 5, pages 43-49.
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