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Food Additives & Contaminants: Part A Volume 32, 2015 - Issue 6
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Original Articles

A rapid method for tetrodotoxin (TTX) determination by LC-MS/MS from small volumes of human serum, and confirmation of pufferfish poisoning by TTX monitoring

Kazunari TsujimuraResearch Department, Division of Food and Drug Hygiene, Nagasaki Prefectural Institute for Environmental Research and Public Health, Omura, Nagasaki, JapanCorrespondence[email protected]
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Kimiko YamanouchiResearch Department, Division of Food and Drug Hygiene, Nagasaki Prefectural Institute for Environmental Research and Public Health, Omura, Nagasaki, JapanView further author information
Pages 977-983 | Received 29 Dec 2014, Accepted 01 Mar 2015, Published online: 14 Apr 2015

Citations (17)

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Li Nan, Wang Jiahui, Li Fengqin & Jiang Tao. (2021) Rapid identification of pufferfish in roast fish fillet by real-time PCR. Food Additives & Contaminants: Part A 38:6, pages 1028-1033.
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Articles from other publishers (16)

Ming-rong Qian, Hui-zhen Wu, Zeng-xuan Cai, Mei-jia Xu, Jian-long Han & Xiao-min Xu. (2023) Determination of tetrodotoxin in bivalve mollusks by hydrophilic interaction liquid chromatography-triple quadrupole mass spectrometry with internal standard calibration and its contamination in Zhejiang province, China. Food Chemistry, pages 137493.
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Jian-Long Han, Lei Zhang, Ping-Ping Zhou, Jiao-Jiao Xu, Xiao-Dong Pan, Pei Cao & Xiao-Min Xu. (2023) Analytical Method Optimization of Tetrodotoxin and Its Contamination in Gastropods. Foods 12:16, pages 3103.
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Renjin Zheng, Lingyi Huang, Youjia Wu, Shouer Lin & Liying Huang. (2023) Simultaneous analysis of paralytic shellfish toxins and tetrodotoxins in human serum by liquid chromatography coupled to Q-Exactive high-resolution mass spectrometry. Journal of Chromatography B 1215, pages 123565.
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Tong Li, Ruiguo Wang & Peilong Wang. (2022) Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin. Molecules 27:24, pages 8967.
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Kazunari Tsujimura, Hironobu Matsuo, Kaori Taniguchi & Hiroki Yoshimura. (2022) Tetrodotoxin Intoxications in Nagasaki, Japan: Symptoms of Patients, Tetrodotoxin Levels in Leftover Food and Clinical Urine and Serum Samples長崎県で発生したフグおよびキンシバイの食中毒事例における食品残品，患者血清および尿中テトロドトキシン含量と症状との関係. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 63:5, pages 182-189.
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Debabrata Panda, Bisnu P. Dash, Sivakumar Manickam & Grzegorz Boczkaj. (2021) Recent advancements in LC‐MS based analysis of biotoxins: Present and future challenges. Mass Spectrometry Reviews 41:5, pages 766-803.
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Panagiota Katikou, Cengiz Gokbulut, Ali Rıza Kosker, Mònica Campàs & Fatih Ozogul. (2022) An Updated Review of Tetrodotoxin and Its Peculiarities. Marine Drugs 20:1, pages 47.
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Man Zhang, Yu Wang, Pian Wu, Weiya Wang, Yaqian Cheng, Lei Huang, Jialei Bai, Yuan Peng, Baoan Ning, Zhixian Gao & Baolin Liu. (2020) Development of a highly sensitive detection method for TTX based on a magnetic bead-aptamer competition system under triple cycle amplification. Analytica Chimica Acta 1119, pages 18-24.
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Yifeng Lan, Guojie Qin, Yanli Wei, Li Wang & Chuan Dong. (2020) Exonuclease I-assisted fluorescence aptasensor for tetrodotoxin. Ecotoxicology and Environmental Safety 194, pages 110417.
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Yifeng Lan, Guojie Qin, Yanli Wei, Chuan Dong & Li Wang. (2019) Highly sensitive analysis of tetrodotoxin based on free-label fluorescence aptamer sensing system. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 219, pages 411-418.
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Andrea Boente-Juncal, Carmen Vale, Manuel Cifuentes, Paz Otero, Mercedes Camiña, Mercedes Rodriguez-Vieytes & Luis Miguel Botana. (2019) Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity. Toxins 11:2, pages 96.
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Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi & Shin-ichi Kubo. (2018) Quantitation of tetrodotoxin in postmortem specimens using SPE and HILIC LC-MS/MS : Tissue distribution of a forensic autopsy case. Japanese Journal of Forensic Science and Technology 23:2, pages 125-131.
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Bihong Hong, Hui Chen, Jiacai Han, Quanling Xie, Jianlin He, Kaikai Bai, Yanming Dong & Ruizao Yi. (2017) A Study of 11-[3H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats. Marine Drugs 15:6, pages 159.
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Paula Abal, M. Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes Vieytes & Luis Botana. (2017) Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL). Toxins 9:3, pages 75.
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Rebecca Coleman, Sharon W. Lemire, William Bragg, Alaine Garrett, Geovannie Ojeda-Torres, Elizabeth Hamelin, Rudolph C. Johnson & Jerry Thomas. (2016) Development and validation of a high-throughput online solid phase extraction – Liquid chromatography – Tandem mass spectrometry method for the detection of tetrodotoxin in human urine. Toxicon 119, pages 64-71.
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Xiao-min Xu, Xin-wei Yu, Meiling Lu, Bai-fen Huang & Yi-ping Ren. (2015) Study of the matrix effects of tetrodotoxin and its content in cooked seafood by liquid chromatography with triple quadrupole mass spectrometry. Journal of Separation Science 38:19, pages 3374-3382.
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