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Statistics in Biopharmaceutical Research Volume 12, 2020 - Issue 2: Evolution of Statistical Science: Translating Data to Innovative Health Care
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Original Articles

Advanced Utilization of Intermediate Endpoints for Making Optimized Cost-Effective Decisions in Seamless Phase II/III Oncology Trials

Linda Z. SunBiostatistics and Research Decision Sciences, MRL, Merck & Co., Inc., Kenilworth, NJ
,
Wen LiBiostatistics and Research Decision Sciences, MRL, Merck & Co., Inc., Kenilworth, NJCorrespondence[email protected]
,
Cong ChenBiostatistics and Research Decision Sciences, MRL, Merck & Co., Inc., Kenilworth, NJ
&
Jing ZhaoBiostatistics and Research Decision Sciences, MRL, Merck & Co., Inc., Kenilworth, NJ
Pages 224-233 | Received 10 Sep 2018, Accepted 17 Aug 2019, Published online: 11 Oct 2019

Citations (7)

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Read on this site (3)

Xiaofei Bai & Qiqi Deng. (2023) Incorporating Intermediate Endpoint in Two-Stage Design Decision Making. Statistics in Biopharmaceutical Research 15:3, pages 510-518.
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Xuekui Zhang, Haijun Jia, Li Xing & Cong Chen. (2023) Application of Group Sequential Methods to the 2-in-1 Design and Its Extensions for Interim Monitoring. Statistics in Biopharmaceutical Research 0:0, pages 1-10.
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Qing Li, Jianchang Lin, Mengya Liu, Liwen Wu & Yingying Liu. (2022) Using Surrogate Endpoints in Adaptive Designs with Delayed Treatment Effect. Statistics in Biopharmaceutical Research 14:4, pages 661-670.
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Articles from other publishers (4)

Benjamin Duputel, Nigel Stallard, François Montestruc, Sarah Zohar & Moreno Ursino. (2023) Using dichotomized survival data to construct a prior distribution for a Bayesian seamless Phase II/III clinical trial. Statistical Methods in Medical Research 32:5, pages 963-977.
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Wen Li, Heng Zhou, Calvin Jia & Linda Sun. (2022) Family-wise type I error rate control for an extended 2-in-1 design with graphical approach in oncology drug development. Contemporary Clinical Trials 119, pages 106846.
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Wen Li, Xiaofei Bai, Qiqi Deng, Fang Liu & Cong Chen. (2021) Estimation of treatment effect in 2‐in‐1 adaptive design and some of its extensions. Statistics in Medicine 40:11, pages 2556-2577.
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Qing Li, Jianchang Lin & Yunzhi Lin. (2020) Adaptive design implementation in confirmatory trials: methods, practical considerations and case studies. Contemporary Clinical Trials 98, pages 106096.
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