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Original Articles

Inflammatory Gene Variants in the Tsimane, an Indigenous Bolivian Population with a High Infectious Load

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Pages 33-52 | Published online: 16 May 2011

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Aaron D. Blackwell, Benjamin C. Trumble, Ivan Maldonado Suarez, Jonathan Stieglitz, Bret Beheim, J. Josh Snodgrass, Hillard Kaplan & Michael Gurven. (2016) Immune function in Amazonian horticulturalists. Annals of Human Biology 43:4, pages 382-396.
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Articles from other publishers (31)

Benjamin C. Trumble, Mia Charifson, Tom Kraft, Angela R. GarciaDaniel K. Cummings, Paul Hooper, Amanda J. Lea, Daniel Eid Rodriguez, Stephanie V. Koebele, Kenneth BuetowBret Beheim, Riana Minocher, Maguin GutierrezGregory S. ThomasMargaret Gatz, Jonathan Stieglitz, Caleb E. Finch, Hillard Kaplan & Michael Gurven. (2023) Apolipoprotein- ε 4 is associated with higher fecundity in a natural fertility population . Science Advances 9:32.
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Chris P. Verschoor, Caitlyn Vlasschaert, Michael J. Rauh & Guillaume Paré. (2023) A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysis. Aging Cell 22:7.
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Carr J. Smith & J. Wesson Ashford. (2023) Apolipoprotein ɛ4-Associated Protection Against Pediatric Enteric Infections Is a Survival Advantage in Pre-Industrial Populations. Journal of Alzheimer's Disease 93:3, pages 907-918.
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Daniel Kolbe, Nicolas A. da Silva, Janina Dose, Guillermo G. Torres, Amke Caliebe, Ben Krause‐Kyora & Almut Nebel. (2023) Current allele distribution of the human longevity gene APOE in Europe can mainly be explained by ancient admixture . Aging Cell 22:5.
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Reinaldo B. Oriá, Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant & Michael P. Vitek. (2023) ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers. Pharmaceutics 15:4, pages 1086.
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Raul S Freitas, Cássia R Roque, Gabriella A Matos, Ludmila Belayev, Orleâncio G R de Azevedo, Jacqueline I Alvarez-Leite, Richard L Guerrant & Reinaldo B Oriá. (2022) Immunoinflammatory role of apolipoprotein E4 in malnutrition and enteric infections and the increased risk for chronic diseases under adverse environments. Nutrition Reviews 80:5, pages 1001-1012.
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Diana J. Zajac, Stefan J. Green, Lance A. Johnson & Steven Estus. (2022) APOE genetics influence murine gut microbiome. Scientific Reports 12:1.
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Andrei Irimia, Nikhil N Chaudhari, David J Robles, Kenneth A Rostowsky, Alexander S Maher, Nahian F Chowdhury, Maria Calvillo, Van Ngo, Margaret Gatz, Wendy J Mack, E Meng Law, M Linda Sutherland, James D Sutherland, Christopher J Rowan, L Samuel Wann, Adel H Allam, Randall C Thompson, David E Michalik, Daniel K Cummings, Edmond Seabright, Sarah Alami, Angela R Garcia, Paul L Hooper, Jonathan Stieglitz, Benjamin C Trumble, Michael D Gurven, Gregory S Thomas, Caleb E Finch & Hillard Kaplan. (2021) The Indigenous South American Tsimane Exhibit Relatively Modest Decrease in Brain Volume With Age Despite High Systemic Inflammation. The Journals of Gerontology: Series A 76:12, pages 2147-2155.
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Angela R Garcia, Caleb Finch, Margaret Gatz, Thomas Kraft, Daniel Eid Rodriguez, Daniel Cummings, Mia Charifson, Kenneth Buetow, Bret A Beheim, Hooman Allayee, Gregory S Thomas, Jonathan Stieglitz, Michael D Gurven, Hillard Kaplan & Benjamin C Trumble. (2021) APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population. eLife 10.
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Michael Gurven, Thomas S. Kraft, Sarah Alami, Juan Copajira AdrianEdhitt Cortez LinaresDaniel Cummings, Daniel Eid Rodriguez, Paul L. HooperAdrian V. Jaeggi, Raul Quispe GutierrezIvan Maldonado SuarezEdmond SeabrightHillard Kaplan, Jonathan Stieglitz & Benjamin Trumble. (2020) Rapidly declining body temperature in a tropical human population. Science Advances 6:44.
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Nicholas G. Norwitz & Henry Querfurth. (2020) mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration. Frontiers in Neuroscience 14.
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Daniel D. Sprockett, Melanie Martin, Elizabeth K. Costello, Adam R. Burns, Susan P. Holmes, Michael D. Gurven & David A. Relman. (2020) Microbiota assembly, structure, and dynamics among Tsimane horticulturalists of the Bolivian Amazon. Nature Communications 11:1.
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Hillard S Kaplan, Benjamin C Trumble, Jonathan Stieglitz, Roberta Mendez Mamany, Maguin Gutierrez Cayuba, Leonardina Maito Moye, Sarah Alami, Thomas Kraft, Raul Quispe Gutierrez, Juan Copajira Adrian, Randall C Thompson, Gregory S Thomas, David E Michalik, Daniel Eid Rodriguez & Michael D Gurven. (2020) Voluntary collective isolation as a best response to COVID-19 for indigenous populations? A case study and protocol from the Bolivian Amazon. The Lancet 395:10238, pages 1727-1734.
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Sarinnapha M. Vasunilashorn, Long H. Ngo, Sharon K. Inouye, Tamara G. Fong, Richard N. Jones, Simon T. Dillon, Towia A. Libermann, Margaret O'Connor, Steven E. Arnold, Zhongcong Xie & Edward R. Marcantonio. (2020) Apolipoprotein E genotype and the association between C‐reactive protein and postoperative delirium: Importance of gene‐protein interactions. Alzheimer's & Dementia 16:3, pages 572-580.
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Alexander M. Kulminski, Ian Philipp, Yury Loika, Liang He & Irina Culminskaya. (2020) Haplotype architecture of the Alzheimer's risk in the APOE region via co‐skewness . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 12:1.
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Lyle G. Best, Poojitha Balakrishnan, Shelley A. Cole, Karin Haack, Jonathan M. Kocarnik, Nathan Pankratz, Matthew Z. Anderson, Nora Franceschini, Barbara V. Howard, Elisa T. Lee, Kari E. North, Jason G. Umans, Joseph M. Yracheta, Ana Navas-Acien & V. Saroja Voruganti. (2019) Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. PLOS ONE 14:10, pages e0223574.
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Robert D. Moir & Rudolph E. Tanzi. (2019) Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome. Frontiers in Aging Neuroscience 11.
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Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli & Cristina Giuliani. (2019) The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity. Genes 10:3, pages 222.
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L.C. Pereira, J.C.R Nascimento, J.M.C. Rêgo, K.M. Canuto, M.E. Crespo-Lopez, J.I. Alvarez-Leite, A. Baysan & R.B. Oriá. (2019) Apolipoprotein E, periodontal disease and the risk for atherosclerosis: a review. Archives of Oral Biology 98, pages 204-212.
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Caleb E. Finch. 2019. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Molly Fox. (2018) ‘Evolutionary medicine’ perspectives on Alzheimer’s Disease: Review and new directions. Ageing Research Reviews 47, pages 140-148.
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Caleb E. Finch. 2018. The Role of Global Air Pollution in Aging and Disease. The Role of Global Air Pollution in Aging and Disease 83 130 .
Patricia Huebbe & Gerald Rimbach. (2017) Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors. Ageing Research Reviews 37, pages 146-161.
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Benjamin C. Trumble, Jonathan Stieglitz, Aaron D. Blackwell, Hooman Allayee, Bret Beheim, Caleb E. Finch, Michael Gurven & Hillard Kaplan. (2016) Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager‐horticulturalists with a high parasite burden. The FASEB Journal 31:4, pages 1508-1515.
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Michael Gurven, Jonathan Stieglitz, Benjamin Trumble, Aaron D. Blackwell, Bret Beheim, Helen Davis, Paul Hooper & Hillard Kaplan. (2017) The Tsimane Health and Life History Project: Integrating anthropology and biomedicine. Evolutionary Anthropology: Issues, News, and Reviews 26:2, pages 54-73.
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Reinaldo B. Oriá, Laura E. Murray-Kolb, Rebecca J. Scharf, Laura L. Pendergast, Dennis R. Lang, Glynis L. Kolling & Richard L. Guerrant. (2016) Early-life enteric infections: relation between chronic systemic inflammation and poor cognition in children. Nutrition Reviews 74:6, pages 374-386.
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Jonathan Stieglitz, Benjamin C. Trumble, Melissa Emery Thompson, Aaron D. Blackwell, Hillard Kaplan & Michael Gurven. (2015) Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population. Brain, Behavior, and Immunity 49, pages 130-139.
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Eric C. Shattuck & Michael P. Muehlenbein. (2015) Human sickness behavior: Ultimate and proximate explanations. American Journal of Physical Anthropology 157:1, pages 1-18.
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Jonathan Stieglitz, Bret A. Beheim, Benjamin C. Trumble, Felicia C. Madimenos, Hillard Kaplan & Michael Gurven. (2015) Low mineral density of a weight-bearing bone among adult women in a high fertility population. American Journal of Physical Anthropology 156:4, pages 637-648.
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Orleâncio G. R. Azevedo, David T. Bolick, James K. Roche, Relana F. Pinkerton, Aldo A. M. Lima, Michael P. Vitek, Cirle A. Warren, Reinaldo B. Oriá & Richard L. Guerrant. (2014) Apolipoprotein E Plays a Key Role against Cryptosporidial Infection in Transgenic Undernourished Mice. PLoS ONE 9:2, pages e89562.
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S. A. Borinskaya, A. S. Gureev, A. A. Orlova, E. D. Sanina, A. A. Kim, F. Gasemianrodsari, V. I. Shirmanov, O. P. Balanovsky, D. V. Rebrikov, A. V. Koshechkin & N. K. Yankovsky. (2013) Allele frequency distributions of -174G/C polymorphism in regulatory region of interleukin 6 gene (IL6) in Russian and worldwide populations. Russian Journal of Genetics 49:1, pages 98-109.
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