Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

Seung Yoon Leea Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea;b Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea;c Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, KoreaView further author information

JooYeon Jhuna Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea;b Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea;c Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, KoreaView further author information

Jin Seok Wooa Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea;b Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, KoreaView further author information

Kun Hee Leea Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea;b Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea;c Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, KoreaView further author information

Sun-Hee Hwanga Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea;b Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, KoreaView further author information

Jeonghyeon Moond Departments of Immunobiology and Neurology, Yale School of Medicine, New Haven, CT, USAView further author information

Goeun Parke Division of Biomedical Convergence, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, KoreaView further author information

Sun Shim Choie Division of Biomedical Convergence, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, KoreaView further author information

So Jung Kimf Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaView further author information

Yoon Ju Jungg Division of Gastrointestinal Surgery, Department of Surgery, Yeouido St. Mary’s Hospital, Seoul, KoreaView further author information

Kyo Young Songf Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaCorrespondence[email protected]
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Mi-La Choa Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea;b Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea;c Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea;h Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, KoreaCorrespondence[email protected]

https://orcid.org/0000-0001-5715-3989 View further author information

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Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

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Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer

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