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Journal of Extracellular Vesicles Volume 6, 2017 - Issue 1
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Original Research Article

Acute lymphoblastic leukaemia cells produce large extracellular vesicles containing organelles and an active cytoskeleton

Suzanne M. JohnsonChildren’s Cancer Group, Division of Molecular and Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-7295-3036View further author information
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Clare DempseyChildren’s Cancer Group, Division of Molecular and Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKView further author information
,
Catriona ParkerChildren’s Cancer Group, Division of Molecular and Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKView further author information
,
Aleksandr MironovChildren’s Cancer Group, Division of Molecular and Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKORCID Iconhttp://orcid.org/0000-0002-1497-328XView further author information
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Helen BradleyFaculty of Biology, Medicine and Health, CRUK Manchester Institute, University of Manchester, Manchester, UKORCID Iconhttp://orcid.org/0000-0002-4246-9830View further author information
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Vaskar SahaChildren’s Cancer Group, Division of Molecular and Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata, IndiaORCID Iconhttp://orcid.org/0000-0002-2916-9649View further author information
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Article: 1294339 | Received 07 Aug 2016, Accepted 26 Jan 2017, Published online: 10 Mar 2017

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Ivan K. H. Poon, Michael A. F. Parkes, Lanzhou Jiang, Georgia K. Atkin-Smith, Rochelle Tixeira, Christopher D. Gregory, Dilara C. Ozkocak, Stephanie F. Rutter, Sarah Caruso, Jascinta P. Santavanond, Stephanie Paone, Bo Shi, Amy L. Hodge, Mark D. Hulett, Jenny D. Y. Chow, Thanh Kha Phan & Amy A. Baxter. (2019) Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles in vitro. Journal of Extracellular Vesicles 8:1.
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Articles from other publishers (29)

Igor Pottosin, Miguel Olivas-Aguirre & Oxana Dobrovinskaya. (2023) In vitro simulation of the acute lymphoblastic leukemia niche: a critical view on the optimal approximation for drug testing. Journal of Leukocyte Biology 114:1, pages 21-41.
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Fawad Ur Rehman, Yang Liu, Meng Zheng & Bingyang Shi. (2023) Exosomes based strategies for brain drug delivery. Biomaterials 293, pages 121949.
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Maria Thastrup, Alasdair Duguid, Christian Mirian, Kjeld Schmiegelow & Christina Halsey. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions. Leukemia 36:12, pages 2751-2768.
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Boon Cheng Chew, Fong Fong Liew, Hsiao Wei Tan & Ivy Chung. (2022) Chemical Advances in Therapeutic Application of Exosomes and Liposomes. Current Medicinal Chemistry 29:25, pages 4445-4473.
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Janne Capra, Kai Härkönen, Heikki Kyykallio, Helena Vihinen, Eija Jokitalo & Kirsi Rilla. (2022) Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells. European Journal of Cell Biology 101:3, pages 151235.
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Alessandra Fallati, Noemi Di Marzo, Giovanna D’Amico & Erica Dander. (2022) Mesenchymal Stromal Cells (MSCs): An Ally of B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells in Disease Maintenance and Progression within the Bone Marrow Hematopoietic Niche. Cancers 14:14, pages 3303.
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Anastasia M. Hughes, Vincent Kuek, Rishi S. Kotecha & Laurence C. Cheung. (2022) The Bone Marrow Microenvironment in B-Cell Development and Malignancy. Cancers 14:9, pages 2089.
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Anup S. Pathania, Philip Prathipati & Kishore B. Challagundla. (2021) New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:2, pages 188624.
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Kirsi Rilla. (2021) Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding. Journal of Extracellular Vesicles 10:11.
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Jihane Khalife, James F. Sanchez & Flavia Pichiorri. (2021) The Emerging Role of Extracellular Vesicle-Associated RNAs in the Multiple Myeloma Microenvironment. Frontiers in Oncology 11.
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Hooi Ching Lim, Shamit Soneji, Róbert Pálmason, Stig Lenhoff, Thomas Laurell & Stefan Scheding. (2021) Development of acoustically isolated extracellular plasma vesicles for biomarker discovery in allogeneic hematopoietic stem cell transplantation. Biomarker Research 9:1.
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Claire L. Pritchard, Shen Y. Heazlewood & Benjamin Cao. 2021. The Cancer Stem Cell Niche. The Cancer Stem Cell Niche 1 34 .
Jihane Khalife, James F. Sanchez & Flavia Pichiorri. (2020) Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools. Diagnostics 10:12, pages 1065.
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Suzanne M Johnson, Antonia Banyard, Christopher Smith, Aleksandr Mironov & Martin G. McCabe. (2020) Large Extracellular Vesicles Can be Characterised by Multiplex Labelling Using Imaging Flow Cytometry. International Journal of Molecular Sciences 21:22, pages 8723.
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Denis Corbeil, Mark F. Santos, Jana Karbanová, Thomas Kurth, Germana Rappa & Aurelio Lorico. (2020) Uptake and Fate of Extracellular Membrane Vesicles: Nucleoplasmic Reticulum-Associated Late Endosomes as a New Gate to Intercellular Communication. Cells 9:9, pages 1931.
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Wei Ding, Olivia C. Rivera, Shannon L. Kelleher & David I. Soybel. (2020) Macrolets: Outsized Extracellular Vesicles Released from Lipopolysaccharide-Stimulated Macrophages that Trap and Kill Escherichia coli. iScience 23:6, pages 101135.
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Fen Zhou, Yuxi Wen, Runming Jin & Hongbo Chen. (2019) New attempts for central nervous infiltration of pediatric acute lymphoblastic leukemia. Cancer and Metastasis Reviews 38:4, pages 657-671.
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Theodor Borgovan, Lorin Crawford, Chibuikem Nwizu & Peter Quesenberry. (2019) Stem cells and extracellular vesicles: biological regulators of physiology and disease. American Journal of Physiology-Cell Physiology 317:2, pages C155-C166.
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Jérémie Gaudichon, Hélène Jakobczyk, Lydie Debaize, Elie Cousin, Marie-Dominique Galibert, Marie-Bérengère Troadec & Virginie Gandemer. (2019) Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: Reconciling biological concepts and clinical issues. Blood Reviews 36, pages 40-56.
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Kirsi Rilla, Anne-Mari Mustonen, Uma Thanigai Arasu, Kai Härkönen, Johanna Matilainen & Petteri Nieminen. (2019) Extracellular vesicles are integral and functional components of the extracellular matrix. Matrix Biology 75-76, pages 201-219.
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Joanna Kowal & Mercedes Tkach. 2019. Immunobiology of Dendritic Cells Part B. Immunobiology of Dendritic Cells Part B 213 249 .
Cornelia D. Cudrici, Elisa A. Ferrante & Manfred Boehm. 2019. Coronary Calcium. Coronary Calcium 47 82 .
Fawad Ur Rehman, Tianyu Du, Sana Shaikh, Xuerui Jiang, Yun Chen, Xiaoqi Li, Huan Yi, Jiang Hui, Baoan Chen, Matthias Selke & Xuemei Wang. (2018) Nano in nano: Biosynthesized gold and iron nanoclusters cargo neoplastic exosomes for cancer status biomarking. Nanomedicine: Nanotechnology, Biology and Medicine 14:8, pages 2619-2631.
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Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez & Jacco van Rheenen. (2018) Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. The EMBO Journal 37:15.
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Junko H. Ohyashiki, Tomohiro Umezu & Kazuma Ohyashiki. (2017) Extracellular vesicle-mediated cell–cell communication in haematological neoplasms. Philosophical Transactions of the Royal Society B: Biological Sciences 373:1737, pages 20160484.
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Mercedes Tkach, Joanna Kowal & Clotilde Théry. (2017) Why the need and how to approach the functional diversity of extracellular vesicles. Philosophical Transactions of the Royal Society B: Biological Sciences 373:1737, pages 20160479.
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Alejandro Pando, John L. Reagan, Peter Quesenberry & Loren D. Fast. (2018) Extracellular vesicles in leukemia. Leukemia Research 64, pages 52-60.
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Uma Thanigai Arasu, Riikka Kärnä, Kai Härkönen, Sanna Oikari, Arto Koistinen, Heikki Kröger, Chengjuan Qu, Mikko J. Lammi & Kirsi Rilla. (2017) Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles. Matrix Biology 64, pages 54-68.
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Catherine Lynch, Maria Panagopoulou & Christopher D. Gregory. (2017) Extracellular Vesicles Arising from Apoptotic Cells in Tumors: Roles in Cancer Pathogenesis and Potential Clinical Applications. Frontiers in Immunology 8.
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