1,821
Views
33
CrossRef citations to date
0
Altmetric
Point-of-View

More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?

&
Pages 32-39 | Received 30 Sep 2016, Accepted 12 Oct 2016, Published online: 14 Nov 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Marianna Lucafò, Martina Franzin, Giuliana Decorti & Gabriele Stocco. (2020) A patent review of anticancer glucocorticoid receptor modulators (2014-present). Expert Opinion on Therapeutic Patents 30:5, pages 313-324.
Read now

Articles from other publishers (32)

Stanko N. Nikolić, Sho Oasa, Aleksandar J. Krmpot, Lars Terenius, Milivoj R. Belić, Rudolf Rigler & Vladana Vukojević. (2023) Mapping the Direction of Nucleocytoplasmic Transport of Glucocorticoid Receptor (GR) in Live Cells Using Two-Foci Cross-Correlation in Massively Parallel Fluorescence Correlation Spectroscopy (mpFCS). Analytical Chemistry 95:41, pages 15171-15179.
Crossref
Sandra Postel, Lisa Wissler, Carina A. Johansson, Anders Gunnarsson, Euan Gordon, Barry Collins, Marie Castaldo, Christian Köhler, David Öling, Patrik Johansson, Linda Fröderberg Roth, Brice Beinsteiner, Ian Dainty, Stephen Delaney, Bruno P. Klaholz, Isabelle M. L. Billas & Karl Edman. (2023) Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nature Structural & Molecular Biology 30:3, pages 286-295.
Crossref
Onno C. Meijer, Jacobus C. Buurstede, Eva M. G. Viho, Jorge Miguel Amaya, Anne‐Sophie C. A. M. Koning, Merel van der Meulen, Lisa T. C. M. van Weert, Susana N. Paul, Jan Kroon & Lisa L. Koorneef. (2022) Transcriptional glucocorticoid effects in the brain: Finding the relevant target genes. Journal of Neuroendocrinology 35:2.
Crossref
Adali Pecci, María Florencia Ogara, Rosario T. Sanz & Guillermo Pablo Vicent. (2022) Choosing the right partner in hormone-dependent gene regulation: Glucocorticoid and progesterone receptors crosstalk in breast cancer cells. Frontiers in Endocrinology 13.
Crossref
Sabine Vettorazzi, Denis Nalbantoglu, J. Christof M. Gebhardt & Jan Tuckermann. (2021) A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology. The FEBS Journal 289:19, pages 5718-5743.
Crossref
Claudia Grossmann, Brian Almeida‐Prieto, Alexander Nolze & Diego Alvarez de la Rosa. (2021) Structural and molecular determinants of mineralocorticoid receptor signalling. British Journal of Pharmacology 179:13, pages 3103-3118.
Crossref
Nikolaos P. Daskalakis, Onno C. Meijer & E. Ron de Kloet. (2022) Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy. Neurobiology of Stress 18, pages 100455.
Crossref
Liangyin He, Xiaoli Shi, Xianyuan Zeng, Fengfang Zhou, Tianzheng Lan, Maosen Chen & Kunhuang Han. (2022) Characterization of the glucocorticoid receptor of large yellow croaker (Larimichthys crocea) and its expression in response to salinity and immune stressors. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 265, pages 111124.
Crossref
Steven Timmermans, Jolien Vandewalle & Claude Libert. (2022) Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)physiology: A Primer. Cells 11:4, pages 683.
Crossref
Davide Marchi & Fredericus J. M. van Eeden. (2021) Homeostatic Regulation of Glucocorticoid Receptor Activity by Hypoxia-Inducible Factor 1: From Physiology to Clinic. Cells 10:12, pages 3441.
Crossref
Lisa M. Sevilla, Alba Jiménez-Panizo, Andrea Alegre-Martí, Eva Estébanez-Perpiñá, Carme Caelles & Paloma Pérez. (2021) Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways. International Journal of Molecular Sciences 22:18, pages 10049.
Crossref
Laurent Bianchetti, Deniz Sinar, Camille Depenveiller & Annick Dejaegere. (2021) Insights into mineralocorticoid receptor homodimerization from a combined molecular modeling and bioinformatics study. Proteins: Structure, Function, and Bioinformatics 89:8, pages 952-965.
Crossref
David A Garcia, Gregory Fettweis, Diego M Presman, Ville Paakinaho, Christopher Jarzynski, Arpita Upadhyaya & Gordon L Hager. (2021) Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model. Nucleic Acids Research 49:12, pages 6605-6620.
Crossref
Lara Malik Noureddine, Olivier Trédan, Nader Hussein, Bassam Badran, Muriel Le Romancer & Coralie Poulard. (2021) Glucocorticoid Receptor: A Multifaceted Actor in Breast Cancer. International Journal of Molecular Sciences 22:9, pages 4446.
Crossref
David A. Garcia, Thomas A. Johnson, Diego M. Presman, Gregory Fettweis, Kaustubh Wagh, Lorenzo Rinaldi, Diana A. Stavreva, Ville Paakinaho, Rikke A.M. Jensen, Susanne Mandrup, Arpita Upadhyaya & Gordon L. Hager. (2021) An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors. Molecular Cell 81:7, pages 1484-1498.e6.
Crossref
Thomas A. Johnson, Ville Paakinaho, Sohyoung Kim, Gordon L. Hager & Diego M. Presman. (2021) Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms. Nature Communications 12:1.
Crossref
Eva Estébanez-Perpiñá, Charlotte L. Bevan & Iain J. McEwan. (2021) Eighty Years of Targeting Androgen Receptor Activity in Prostate Cancer: The Fight Goes on. Cancers 13:3, pages 509.
Crossref
Martin Stortz, Diego M. Presman, Adali Pecci & Valeria Levi. (2021) Phasing the intranuclear organization of steroid hormone receptors. Biochemical Journal 478:2, pages 443-461.
Crossref
S. Ginosyan, H. Grabski & S. Tiratsuyan. (2020) In vitro and in silico Determination of the Interaction of Artemisinin with Human Serum Albumin. Molecular Biology 54:4, pages 586-598.
Crossref
Karolien De Bosscher, Sofie J. Desmet, Dorien Clarisse, Eva Estébanez-Perpiña & Luc Brunsveld. (2020) Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation. Nature Reviews Endocrinology 16:7, pages 363-377.
Crossref
Ana C. Liberman, Maia L. Budziñski, Clara Sokn, Romina P. Gobbini, Maria B. Ugo & Eduardo Arzt. (2020) SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress. Steroids 153, pages 108520.
Crossref
Diana A. Stavreva, David A. Garcia, Gregory Fettweis, Prabhakar R. Gudla, George F. Zaki, Vikas Soni, Andrew McGowan, Geneva Williams, Anh Huynh, Murali Palangat, R. Louis Schiltz, Thomas A. Johnson, Diego M. Presman, Matthew L. Ferguson, Gianluca Pegoraro, Arpita Upadhyaya & Gordon L. Hager. (2019) Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility. Molecular Cell 75:6, pages 1161-1177.e11.
Crossref
Ville Paakinaho, Thomas A. Johnson, Diego M. Presman & Gordon L. Hager. (2019) Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome. Genome Research 29:8, pages 1223-1234.
Crossref
Ann Louw. (2019) GR Dimerization and the Impact of GR Dimerization on GR Protein Stability and Half-Life. Frontiers in Immunology 10.
Crossref
Steven Timmermans, Jolien Souffriau & Claude Libert. (2019) A General Introduction to Glucocorticoid Biology. Frontiers in Immunology 10.
Crossref
Onno C. Meijer, J. C. Buurstede & Marcel J. M. Schaaf. (2018) Corticosteroid Receptors in the Brain: Transcriptional Mechanisms for Specificity and Context-Dependent Effects. Cellular and Molecular Neurobiology 39:4, pages 539-549.
Crossref
Ying-Jun Ning, Si-Ying Chen, Xin-Jiang Lu, Jian-Fei Lu & Jiong Chen. (2019) Glucocorticoid receptor in ayu (Plecoglossus altivelis): Genomic and non-genomic effects on monocytes/macrophages function. Fish & Shellfish Immunology 86, pages 1151-1161.
Crossref
Sho Oasa, Shintaro Mikuni, Johtaro Yamamoto, Tsumugi Kurosaki, Daisuke Yamashita & Masataka Kinjo. (2018) Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System. Scientific Reports 8:1.
Crossref
E.R. de Kloet, O.C. Meijer, A.F. de Nicola, R.H. de Rijk & M. Joëls. (2018) Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation. Frontiers in Neuroendocrinology 49, pages 124-145.
Crossref
J. E. HassellJr.Jr., K. T. Nguyen, C. A. Gates & C. A. Lowry. 2019. Neuroendocrine Regulation of Behavior. Neuroendocrine Regulation of Behavior 271 321 .
Lautaro Damián Álvarez, Diego Martín Presman & Adalí Pecci. (2017) Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain suggest a role of the lever-arm mobility in transcriptional output. PLOS ONE 12:12, pages e0189588.
Crossref
Daniel M. Cohen & David J. Steger. (2017) Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor. Trends in Endocrinology & Metabolism 28:7, pages 531-540.
Crossref