Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers – a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale

Michael S. KostapanosDivision of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK; ;Lipid Clinic, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Correspondence[email protected]

Paul J. CacciottoloDivision of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK;

Annette HubschDivision of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK;

Holly PaveyCardiovascular Trials Office, Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

http://orcid.org/0000-0001-5014-5118

James HurlockCardiovascular Trials Office, Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

Kaisa Maki-PetajaDivision of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK;

Ian B. WilkinsonDivision of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK; ;Cardiovascular Trials Office, Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

Joseph CheriyanDivision of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK; ;Cardiovascular Trials Office, Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers – a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale

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Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers – a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale

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