Advanced search
Publication Cover
Adipocyte Volume 6, 2017 - Issue 2
Submit an article Journal homepage
3,155
Views
24
CrossRef citations to date
0
Altmetric
Research Paper

Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression

Si Brask SonneUCSF Diabetes Center and Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, USA;Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark
,
Rachita YadavLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark;Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark
,
Guangliang YinBGI-Shenzhen, Shenzhen, China
,
Marlene Danner DalgaardDTU Multi-Assay Core (DMAC), Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark
,
Lene Secher MyrmelNational Institute of Nutrition and Seafood Research, Bergen, Norway
,
Ramneek GuptaDepartment of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, DenmarkCorrespondence[email protected]
,
Jun WangLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark;BGI-Shenzhen, Shenzhen, China
,
Lise MadsenLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark;BGI-Shenzhen, Shenzhen, China;National Institute of Nutrition and Seafood Research, Bergen, NorwayORCID Iconhttp://orcid.org/0000-0003-4468-1947
ORCID Icon,
Shingo KajimuraUCSF Diabetes Center and Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, USA
&
Karsten KristiansenLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark;BGI-Shenzhen, Shenzhen, ChinaORCID Iconhttp://orcid.org/0000-0002-6024-0917
ORCID Icon show all
Pages 124-133 | Received 19 Jan 2017, Accepted 11 Apr 2017, Published online: 08 May 2017

Citations (24)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Amsha Viraragavan, Tarryn Willmer, Oelfah Patel, Albertus Basson, Rabia Johnson & Carmen Pheiffer. (2021) Cafeteria diet induces global and Slc27a3-specific hypomethylation in male Wistar rats. Adipocyte 10:1, pages 108-118.
Read now

Articles from other publishers (23)

Adam Olichwier, Adrian Sowka, Volodymyr V. Balatskyi, Ana-Maria Gan, Anna Dziewulska & Pawel Dobrzyn. (2024) SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1871:1, pages 119608.
Crossref
Yifan Lv, Fan Xia, Jing Yu, Yunlu Sheng, Yi Jin, Yanqiang Li & Guoxian Ding. (2023) Distinct response of adipocyte progenitors to glucocorticoids determines visceral obesity via the TEAD1‐miR‐27b‐PRDM16 axis . Obesity.
Crossref
C. Óvilo, N. Trakooljul, Y. Núñez, F. Hadlich, E. Murani, M. Ayuso, C. García-Contreras, M. Vázquez-Gómez, A. I. Rey, F. Garcia, J. M. García-Casco, C. López-Bote, B. Isabel, A. González-Bulnes, K. Wimmers & M. Muñoz. (2022) SNP discovery and association study for growth, fatness and meat quality traits in Iberian crossbred pigs. Scientific Reports 12:1.
Crossref
Xiaomin Gao, Xiang Shi, Shujian Zhou, Chen Chen, Cai Hu, Qian Xia, Xinlin Li, Wen Gao, Ying Ding, Qisheng Zuo, Yani Zhang & Bichun Li. (2022) DNA hypomethylation activation Wnt/TCF7L2/TDRD1 pathway promotes spermatogonial stem cell formation. Journal of Cellular Physiology 237:9, pages 3640-3650.
Crossref
Yashaswi Sharma & António Miguel Galvão. (2022) Maternal obesity and ovarian failure: is leptin the culprit?. Animal Reproduction 19:4.
Crossref
Hao Xie, Xin Liu, Qing Zhou, Teng Huang, Lu Zhang, Jia Gao, Yuhan Wang, Yanjun Liu, Tong Yan, Shu Zhang & Cong-Yi Wang. (2022) DNA Methylation Modulates Aging Process in Adipocytes. Aging and disease 13:2, pages 433.
Crossref
Yanhong Li, Jie Wang, Mauricio A. Elzo, Huimei Fan, Kun Du, Siqi Xia, Jiahao Shao, Tianfu Lai, Shenqiang Hu, Xianbo Jia & Songjia Lai. (2021) Molecular Profiling of DNA Methylation and Alternative Splicing of Genes in Skeletal Muscle of Obese Rabbits. Current Issues in Molecular Biology 43:3, pages 1558-1575.
Crossref
Xiang-jin Zheng, Wan Li, Jie Yi, Jin-yi Liu, Li-wen Ren, Xiao-ming Zhu, Shi-wei Liu, Jin-hua Wang & Guan-hua Du. (2020) EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Acta Pharmacologica Sinica 42:7, pages 1171-1179.
Crossref
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L. Seabra, Miguel Constância & Mariana P. Monteiro. (2021) Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review. Frontiers in Endocrinology 12.
Crossref
Ningyuan Chen, Liu Miao, Wei Lin, Donghua Zou, Ling Huang, Jia Huang, Wanxin Shi, Lilin Li, Yuxing Luo, Hao Liang, Shangling Pan & Junhua Peng. (2021) Integrated DNA Methylation and Gene Expression Analysis Identified S100A8 and S100A9 in the Pathogenesis of Obesity. Frontiers in Cardiovascular Medicine 8.
Crossref
Abdelaziz Ghanemi, Mayumi Yoshioka & Jonny St-Amand. (2021) Obese Animals as Models for Numerous Diseases: Advantages and Applications. Medicina 57:5, pages 399.
Crossref
Yoon Jeong ParkSangseon Lee, Sangsoo LimHahn NahmgoongYul JiJin Young Huh, Assim A. Alfadda, Sun Kim & Jae Bum Kim. (2021) DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics. Proceedings of the National Academy of Sciences 118:11.
Crossref
Rosario B. Jaime-Lara, Abhrarup Roy, Yupeng Wang, Ansley Stanfill, Ann K. Cashion & Paule V. Joseph. (2020) Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients. BMC Medical Genomics 13:1.
Crossref
Xiaofei Zhu, Xin Jia, Fangyun Cheng, Haimeng Tian & Yajun Zhou. (2020) c‐Jun acts downstream of PI3K / AKT signaling to mediate the effect of leptin on methionine adenosyltransferase 2B in hepatic stellate cells in vitro and in vivo . The Journal of Pathology 252:4, pages 423-432.
Crossref
Shaza Asif, Nadya M. Morrow, Erin E. Mulvihill & Kyoung-Han Kim. (2020) Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases. Frontiers in Genetics 11.
Crossref
Mojgan Gharipour, Majid Barekatain, Johoon Sung, Naghmeh Emami, Ladan Sadeghian, Minoo Dianatkhah, Nizal Sarrafzadegan & Shayesteh Jahanfar. (2020) The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review. International Journal of Molecular Sciences 21:18, pages 6758.
Crossref
Jun Tao, Yajing Wang, Ling Li, Junmeng Zheng & Shi Liang. (2020) Critical Roles of ELVOL4 and IL-33 in the Progression of Obesity-Related Cardiomyopathy via Integrated Bioinformatics Analysis. Frontiers in Physiology 11.
Crossref
Yingzi Hou, Zhenxi Zhang, Yao Wang, Tao Gao, Xiyang Liu, Tao Tang & Quan Du. (2020) 5mC profiling characterized TET2 as an anti-adipogenic demethylase. Gene 733, pages 144265.
Crossref
Claudia MatthaeusInes LahmannSéverine Kunz, Wenke JonasArthur Alves MeloMartin LehmannElin LarssonRichard LundmarkMatthias KernMatthias BlüherHannah OlschowskiJulian KompaBritta BrüggerDominik N. MüllerVolker Haucke, Annette Schürmann, Carmen BirchmeierOliver Daumke. (2020) EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proceedings of the National Academy of Sciences 117:13, pages 7471-7481.
Crossref
Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Karolina Drewniak, Józef Drzewoski, Janusz Szemraj, Jacek Kasznicki & Agnieszka Śliwińska. (2019) Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders. Nutrients 11:8, pages 1872.
Crossref
Bianca Cox, Maria Tsamou, Karen Vrijens, Kristof Y. Neven, Ellen Winckelmans, Theo M. de Kok, Michelle Plusquin & Tim S. Nawrot. (2019) A Co-expression Analysis of the Placental Transcriptome in Association With Maternal Pre-pregnancy BMI and Newborn Birth Weight. Frontiers in Genetics 10.
Crossref
Mengrong Cheng, Bing Mei, Qian Zhou, Manling Zhang, Han Huang, Lanchun Han & Qingyang Huang. (2018) Computational analyses of obesity associated loci generated by genome-wide association studies. PLOS ONE 13:7, pages e0199987.
Crossref
Khushdeep Bandesh, Pawan K. Dhar & Dwaipayan Bharadwaj. 2018. Systems Biology. Systems Biology 17 36 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.