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Adipocyte Volume 8, 2019 - Issue 1

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Research Paper

KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells

Duy Trong Vien DiepGachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon, Republic of KoreaView further author information

Khue Ha Minh DuongGachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon, Republic of KoreaView further author information

Hojung ChoiGachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon, Republic of Korea

https://orcid.org/0000-0001-9235-5500 View further author information

Hee-Sook JunGachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon, Republic of KoreaView further author information

Kwang-Hoon ChunGachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon, Republic of KoreaCorrespondence[email protected]

https://orcid.org/0000-0001-8242-0778 View further author information

Pages 114-124 | Received 28 Nov 2018, Accepted 13 Feb 2019, Published online: 23 Mar 2019

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https://doi.org/10.1080/21623945.2019.1590929
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Alexandra Zanin-Zhorov, Wei Chen, Julien Moretti, Melanie S. Nyuydzefe, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Cindy Serdjebi, Kelli MacDonald, Bruce R. Blazar, Melissa Palmer & Samuel D. Waksal. (2023) Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism. Communications Biology 6:1.
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Sandra Maria Barbalho, Ricardo de Alvares Goulart, Giulia Minniti, Marcelo Dib Bechara, Marcela Vialogo Marques de Castro, Jefferson Aparecido Dias & Lucas Fornari Laurindo. (2023) Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation—a systematic review. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Mingsong Shi, Jiang Liu, Suhong Fu, Heying Pei, Bin Peng, Yi Wen, Haoche Wei, Xin Zhou, Lijuan Chen & Dingguo Xu. (2023) Structural Insights into the Interactions of Belumosudil with Rho-Associated Coiled-Coil Containing Protein Kinases 1 and 2 Based on Molecular Docking, Molecular Dynamics Simulations, and Free Energy Calculations. Journal of Computational Biophysics and Chemistry 22:04, pages 401-422.
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Sunliang Cui. 2023. Privileged Scaffolds in Drug Discovery. Privileged Scaffolds in Drug Discovery 199 226 .

Hossein Babaahmadi-Rezaei, Maryam Rezaei, Hossein Ghaderi-Zefrehi, Masoumeh Azizi, Hasti Beheshti-Nasab & Jawahar Lal Mehta. (2022) Reducing Proteoglycan Synthesis and NOX Activity by ROCK Inhibitors: Therapeutic Targets in Atherosclerosis. Endocrine, Metabolic & Immune Disorders - Drug Targets 22:12, pages 1191-1200.
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Terri L. Levien & Danial E. Baker. (2021) Formulary Drug Review: Belumosudil. Hospital Pharmacy 57:4, pages 435-441.
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Lei Wei & Jianjian Shi. (2022) Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis. Frontiers in Endocrinology 13.
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Megumi Watanabe, Yosuke Ida, Masato Furuhashi, Yuri Tsugeno, Fumihito Hikage & Hiroshi Ohguro. (2021) Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners. Molecules 26:21, pages 6382.
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Nhu Nguyen Quynh Tran & Kwang-Hoon Chun. (2021) ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2. Molecules 26:16, pages 4747.
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Jinling Qin, Weyland Cheng, Yong-Tao Duan, Hua Yang & Yongfang Yao. (2021) Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anti-Cancer Agents in Medicinal Chemistry 21:7, pages 839-860.
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Ji Young Lee, Reece P. Stevens, Mary Kash, Chun Zhou, Anna Koloteva, Phoibe Renema, Sunita S. Paudel & Troy Stevens. (2020) KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability. American Journal of Respiratory Cell and Molecular Biology 63:4, pages 519-530.
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Jinjoo Park & Kwang-Hoon Chun. (2020) Identification of novel functions of the ROCK2-specific inhibitor KD025 by bioinformatics analysis. Gene 737, pages 144474.
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Jin-Ha Yoon, Thi-Thao-Linh Nguyen, Van-An Duong, Kwang-Hoon Chun & Han-Joo Maeng. (2020) Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Pharmacokinetic Application. Molecules 25:6, pages 1369.
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KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells

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KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells

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