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OncoImmunology Volume 4, 2015 - Issue 9
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Original Research

IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity

Rajia BahriInstitute of Inflammation and Repair and MCCIR; University of Manchester; Manchester, UK;Priority Area Asthma and Allergies; Research Center Borstel; Borstel, Germany
,
Ioannis S PaterasMolecular Carcinogenesis Group; Department of Histology & Embryology; School of Medicine; University of Athens; Athens, Greece
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Orietta D’OrlandoPriority Area Asthma and Allergies; Research Center Borstel; Borstel, Germany
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Diego A Goyeneche-PatinoPriority Area Asthma and Allergies; Research Center Borstel; Borstel, Germany
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Michelle CampbellInstitute of Inflammation and Repair and MCCIR; University of Manchester; Manchester, UK
,
Julia K PolanskyPriority Area Asthma and Allergies; Research Center Borstel; Borstel, Germany
,
Hilary SandigInstitute of Inflammation and Repair and MCCIR; University of Manchester; Manchester, UK
,
Marilena PapaioannouMolecular Carcinogenesis Group; Department of Histology & Embryology; School of Medicine; University of Athens; Athens, Greece
,
Kostas EvangelouMolecular Carcinogenesis Group; Department of Histology & Embryology; School of Medicine; University of Athens; Athens, Greece
,
Periklis G FoukasMolecular Carcinogenesis Group; Department of Histology & Embryology; School of Medicine; University of Athens; Athens, Greece;2nd Department of Pathology; University of Athens Medical School; “Attikon” University Hospital; Athens, Greece
,
Vassilis G GorgoulisMolecular Carcinogenesis Group; Department of Histology & Embryology; School of Medicine; University of Athens; Athens, Greece;Biomedical Research Foundation; Academy of Athens; Athens, Greece;Faculty Institute for Cancer Sciences; University of Manchester; Manchester Academic Health Science Centre; Manchester, UK
&
Silvia Bulfone-PausInstitute of Inflammation and Repair and MCCIR; University of Manchester; Manchester, UKCorrespondence[email protected]
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Article: e1002721 | Received 14 Oct 2014, Accepted 20 Dec 2014, Published online: 27 Jul 2015

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Maha H. Daghestani, Hana H. Hakami, Khushboo Ambreen, Abdulaziz M. Saleem, Nadia A. Aleisa, Lina M. Al Neghery & Mohannad H. Amin. (2022) Assessment of tumor-suppressive inflammatory tendency of Echis coloratus venom against colon carcinogenesis, via up-regulation of anti-tumorigenic inflammatory cells and down-regulation of pro-tumorigenic inflammatory cells, in colon cancer cell lines. Toxin Reviews 41:1, pages 11-24.
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Articles from other publishers (20)

Xiang Chen, Ling-Juan Chen, Xiao-Fei Peng, Ling Deng, Yan Wang, Jiu-Jiang Li, Dong-Li Guo & Xiao-Hua Niu. (2024) Anti-PD-1/PD-L1 therapy for colorectal cancer: Clinical implications and future considerations. Translational Oncology 40, pages 101851.
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Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan & Xiaofei Shen. (2023) Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis. Frontiers in Immunology 14.
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Yongming Huang, Xiaoyuan Zhang, PengWang, Yansen Li & Jie Yao. (2022) Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis. BMC Genomic Data 23:1.
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Jun Yuan, Jiarui Li, Ce Gao, Chun Jiang, Ze Xiang & Jian Wu. (2022) Immunotherapies catering to the unmet medical need of cold colorectal cancer. Frontiers in Immunology 13.
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Kathrin Warner, Maryam Ghaedi, Douglas C. Chung, Nicolas Jacquelot & Pamela S. Ohashi. (2022) Innate lymphoid cells in early tumor development. Frontiers in Immunology 13.
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Jia Yang, Yuan Hu, Binjing Zhang, Xiao Liang & Xin Li. (2022) The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer. Frontiers in Immunology 13.
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Maha H Daghestani, Khushboo Ambreen, Hana H Hakami, Mohammed A Omair, Abdulaziz M Saleem, Nadia A Aleisa, Lina M AlNeghery, Mohannad H Amin, Hussah M Alobaid, Maha A Omair & Lena M Hassen. (2021) Venom of the desert black snake Walterinnesia aegyptia enhances anti-tumor immunity via its beneficial modulatory effects on pro- and anti-tumorigenic inflammatory mediators in cultured colon cancer cells . Toxicology Research 10:6, pages 1116-1128.
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Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-André Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Alfredo Menendez & Sheela Ramanathan. (2021) IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes. Frontiers in Immunology 12.
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Sofía Frigerio, Dalia A. Lartey, Geert R. D’Haens & Joep Grootjans. (2021) The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms. International Journal of Molecular Sciences 22:23, pages 12739.
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Shuling Zhang, Jianzhu Zhao, Xueli Bai, Mike Handley & Fengping Shan. (2021) Biological effects of IL-15 on immune cells and its potential for the treatment of cancer. International Immunopharmacology 91, pages 107318.
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Mousumi Mahapatro, Lena Erkert & Christoph Becker. (2021) Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut. Cells 10:1, pages 111.
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Yang Zhang, Ashwani Rajput, Ning Jin & Jing Wang. (2020) Mechanisms of Immunosuppression in Colorectal Cancer. Cancers 12:12, pages 3850.
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Feng Cui, Di Qu, Ruya Sun, Mingming Zhang & Kejun Nan. (2019) NK cell‑produced IFN‑γ regulates cell growth and apoptosis of colorectal cancer by regulating IL‑15. Experimental and Therapeutic Medicine.
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Ka Yee Fung, Paul M. Nguyen & Tracy Putoczki. (2019) The expanding role of innate lymphoid cells and their T-cell counterparts in gastrointestinal cancers. Molecular Immunology 110, pages 48-56.
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Stephen J. Gaudino & Pawan Kumar. (2019) Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis. Frontiers in Immunology 10.
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Imke Atreya, Markus Kindermann & Stefan Wirtz. (2019) Innate lymphoid cells in intestinal cancer development. Seminars in Immunology 41, pages 101267.
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Camille Balbinot, Olivier Armant, Nabila Elarouci, Laetitia Marisa, Elisabeth Martin, Etienne De Clara, Alina Onea, Jacqueline Deschamps, Felix Beck, Jean-Noël Freund & Isabelle Duluc. (2018) The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms. Journal of Experimental Medicine 215:3, pages 911-926.
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Laurence Zitvogel, Jonathan M. Pitt, Romain Daillère, Mark J. Smyth & Guido Kroemer. (2016) Mouse models in oncoimmunology. Nature Reviews Cancer 16:12, pages 759-773.
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Lukas F. Mager, Marie-Hélène Wasmer, Tilman T. Rau & Philippe Krebs. (2016) Cytokine-Induced Modulation of Colorectal Cancer. Frontiers in Oncology 6.
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Julia K. Polansky, Rajia Bahri, Mylene Divivier, Erwin H. Duitman, Christina Vock, Diego A. Goyeneche-Patino, Zane Orinska & Silvia Bulfone-Paus. (2016) High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner. Scientific Reports 6:1.
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