2,309
Views
33
CrossRef citations to date
0
Altmetric
Author's View

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses

, &
Article: e1036214 | Received 03 Mar 2015, Accepted 26 Mar 2015, Published online: 27 Jul 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Constance Le Goux, Sophie Vacher, Géraldine Pignot, Mathilde Sibony, Nicolas Barry Delongchamps, Benoit Terris, Eliane Piaggio, Marc Zerbib, Diane Damotte & Ivan Bieche. (2017) mRNA Expression levels of genes involved in antitumor immunity: Identification of a 3-gene signature associated with prognosis of muscle-invasive bladder cancer. OncoImmunology 6:11.
Read now
Xiao Hu, Xikui Liu, Jacques Moisan, Yahong Wang, Charles A. Lesch, Chauncey Spooner, Rodney W. Morgan, Elizabeth M. Zawidzka, David Mertz, Dick Bousley, Kinga Majchrzak, Ilona Kryczek, Clarke Taylor, Chad Van Huis, Don Skalitzky, Alexander Hurd, Thomas D. Aicher, Peter L. Toogood, Gary D. Glick, Chrystal M. Paulos, Weiping Zou & Laura L. Carter. (2016) Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity. OncoImmunology 5:12.
Read now

Articles from other publishers (31)

Junyan Jin, Xiuwen Wang, Yongzheng Li, Xiaodong Yang, Hu Wang, Xiaoxu Han, Jin Sun, Zhenglai Ma, Junyi DuanGuanghui ZhangTao HuangTong Zhang, Hao Wu, Xin Zhang & Bin Su. (2023) Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine. Chinese Medical Journal.
Crossref
Gabor Dobos, Ingrid Lazaridou & Adèle de Masson. (2023) Mycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression. Cancers 15:3, pages 746.
Crossref
Elizabeth D. Barrows, Matthew J. Blackburn & Stephen V. Liu. (2022) Evolving role of immunotherapy in small cell lung cancer. Seminars in Cancer Biology 86, pages 868-874.
Crossref
Shu Rui, Xiangyu Kong, Jiaye Liu, Liying Wang, Xiaofei Wang, Xiuhe Zou, Xun Zheng, Feng Ye, Heng Xu, Zhihui Li & Han Luo. (2022) The landscape of TIGIT target and clinical application in diseases. MedComm – Oncology 1:2.
Crossref
Binfeng Chen, Baokui Ye, Mengyuan Li, Shuyi Wang, Jin Li, Yimei Lai, Niansheng Yang, Zunfu Ke & Hui Zhang. (2022) TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A–Producing CD4+ Tissue-Resident Memory T Cells. Frontiers in Immunology 13.
Crossref
Elham Masoumi, Sahar Tahaghoghi-Hajghorbani, Leila Jafarzadeh, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi & Davood Bashash. (2021) The application of immune checkpoint blockade in breast cancer and the emerging role of nanoparticle. Journal of Controlled Release 340, pages 168-187.
Crossref
Wenxiang Zhang, Xiangyi Kong, Bolun Ai, Zhongzhao Wang, Xiangyu Wang, Nianchang Wang, Shan Zheng, Yi Fang & Jing Wang. (2021) Research Progresses in Immunological Checkpoint Inhibitors for Breast Cancer Immunotherapy. Frontiers in Oncology 11.
Crossref
Saber Mehdizadeh, Hashem Bayatipoor, Salar Pashangzadeh, Roghayeh Jafarpour, Zeinab Shojaei & Morteza Motallebnezhad. (2021) Immune checkpoints and cancer development: Therapeutic implications and future directions. Pathology - Research and Practice 223, pages 153485.
Crossref
Nina Zila, Christoph Hoeller & Verena Paulitschke. (2021) Novel immune checkpoints beyond PD-1 in advanced melanoma. memo - Magazine of European Medical Oncology 14:2, pages 135-142.
Crossref
Jin G. Jung & Anne Le. 2021. The Heterogeneity of Cancer Metabolism. The Heterogeneity of Cancer Metabolism 173 185 .
Negar Hosseinkhani, Afshin Derakhshani, Omid Kooshkaki, Mahdi Abdoli Shadbad, Khalil Hajiasgharzadeh, Amir Baghbanzadeh, Hossein Safarpour, Ahad Mokhtarzadeh, Oronzo Brunetti, Simon Yue, Nicola Silvestris & Behzad Baradaran. (2020) Immune Checkpoints and CAR-T Cells: The Pioneers in Future Cancer Therapies?. International Journal of Molecular Sciences 21:21, pages 8305.
Crossref
Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G. Lima, Lizeth G. Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, Sebastien Jacquelin, Maike Effern, Brodie Quine, Lambros T. Koufariotis, Mika Casey, Kyohei Nakamura, Eun Y. Seo, Michael Hölzel, Matthias Geyer, Glen Kristiansen, Touraj Taheri, Elizabeth Ahern, Brett G.M. Hughes, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Martin D. Batstone, Jennifer Landsberg, Dimo Dietrich, Oltin T. Pop, Lukas Flatz, William C. Dougall, André Veillette, Sandra E. Nicholson, Andreas Möller, Robert J. Johnston, Ludovic Martinet, Mark J. Smyth & Tobias Bald. (2020) CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells. Immunity 53:4, pages 805-823.e15.
Crossref
Elena Vendrame, Christof Seiler, Thanmayi Ranganath, Nancy Q. Zhao, Rosemary Vergara, Michel Alary, Annie-Claude Labbé, Fernand Guédou, Johanne Poudrier, Susan Holmes, Michel Roger & Catherine A. Blish. (2020) TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells. AIDS 34:6, pages 801-813.
Crossref
Xiao-Dong Su & Yao Shuai. 2020. Regulation of Cancer Immune Checkpoints. Regulation of Cancer Immune Checkpoints 485 530 .
Lara Ambrosi, Shaheer Khan, Richard D. Carvajal & Jessica Yang. (2019) Novel Targets for the Treatment of Melanoma. Current Oncology Reports 21:11.
Crossref
Woo Jin Lee, Ye Jin Lee, Myoung Eun Choi, Kyung A. Yun, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi & Sung Eun Chang. (2019) Expression of lymphocyte-activating gene 3 and T-cell immunoreceptor with immunoglobulin and ITIM domains in cutaneous melanoma and their correlation with programmed cell death 1 expression in tumor-infiltrating lymphocytes. Journal of the American Academy of Dermatology 81:1, pages 219-227.
Crossref
Shuowu Liu, Lizhu Sun, Chuqi Wang, Yingshu Cui, Yuee Ling, Tian Li, Fangxing Lin, Wenyan Fu, Min Ding, Shuyi Zhang, Changhai Lei & Shi Hu. (2019) Treatment of murine lupus with TIGIT-Ig. Clinical Immunology 203, pages 72-80.
Crossref
Deepak Mittal, Ailin Lepletier, Jason Madore, Amelia Roman Aguilera, Kimberley Stannard, Stephen J. Blake, Vicki L.J. Whitehall, Cheng Liu, Mark L. Bettington, Kazuyoshi Takeda, Georgina V. Long, Richard A. Scolyer, Ruth Lan, Nathan Siemers, Alan Korman, Michele W.L. Teng, Robert J. Johnston, William C. Dougall & Mark J. Smyth. (2019) CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function. Cancer Immunology Research 7:4, pages 559-571.
Crossref
Jing Liu, Wenna Jiang, Kaili Zhao, Hongwei Wang, Tianxing Zhou, Weiwei Bai, Xiuchao Wang, Tiansuo Zhao, Chongbiao Huang, Song Gao, Tai Qin, Wenwen Yu, Bo Yang, Xin Li, Danqi Fu, Wei Tan, Shengyu Yang, He Ren & Jihui Hao. (2019) Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma. Journal of Experimental Medicine 216:3, pages 656-673.
Crossref
Shannon Kahan & Allan Zajac. (2019) Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus. Viruses 11:2, pages 156.
Crossref
Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Sudipto Ganguly, Ling Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, David Bernados, Benjamin Murter, Abha Soni, Janis M. Taube, Amanda Nickles Fader, Tian-Li Wang, Ie-Ming Shih, Mark White, Drew M. Pardoll & Spencer C. Liang. (2019) PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. Cancer Immunology Research 7:2, pages 257-268.
Crossref
Pawel Kalinski & Per Basse. 2019. Immune Checkpoint Inhibitors in Cancer. Immune Checkpoint Inhibitors in Cancer 1 17 .
Julian A. Marin-Acevedo, Bhagirathbhai Dholaria, Aixa E. Soyano, Keith L. Knutson, Saranya Chumsri & Yanyan Lou. (2018) Next generation of immune checkpoint therapy in cancer: new developments and challenges. Journal of Hematology & Oncology 11:1.
Crossref
Bei Wang, Wen Zhang, Vladimir JankovicJacquelynn Golubov, Patrick Poon, Erin M. OswaldCagan GurerJoyce Wei, Ilyssa RamosQi WuJanelle Waite, Min NiChristina AdlerYi WeiLynn MacdonaldTracey RowlandsSusannah BrydgesJean SiaoWilliam PoueymirouDouglas MacDonald, George D. YancopoulosMatthew A. SleemanAndrew J. Murphy & Dimitris Skokos. (2018) Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8 + T cell dysfunction and maintain memory phenotype . Science Immunology 3:29.
Crossref
Fengxue Yu, Ning Ma, Xiaolin Zhang, Suzhai Tian, Lianxia Geng, Weili Xu, Mingbang Wang, Yuan Jia, Xuechen Liu, Junji Ma, Yuan Quan, Chaojun Zhang, Lina Guo, Wenting An & Dianwu Liu. (2018) Comprehensive investigating of cytokine and receptor related genes variants in patients with chronic hepatitis B virus infection. Cytokine 103, pages 10-14.
Crossref
Lie Mao, Hongyan Hou, Shiji Wu, Yu Zhou, Juan Wang, Jing Yu, Xiaohui Wu, Yanfang Lu, Liyan Mao, Munyemana Jean Bosco, Feng Wang & Ziyong Sun. (2017) TIGIT signalling pathway negatively regulates CD4 + T-cell responses in systemic lupus erythematosus . Immunology 151:3, pages 280-290.
Crossref
Feng Xu, Alexander Sunderland, Yue Zhou, Richard D. Schulick, Barish H. Edil & Yuwen Zhu. (2017) Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. Cancer Immunology, Immunotherapy.
Crossref
Natan Stein, Pinchas Tsukerman & Ofer Mandelboim. (2017) The paired receptors TIGIT and DNAM-1 as targets for therapeutic antibodies. Human Antibodies 25:3-4, pages 111-119.
Crossref
Carolyn E. Banister, Changlong Liu, Lucia Pirisi, Kim E. Creek & Phillip J. Buckhaults. (2017) Identification and characterization of HPV-independent cervical cancers. Oncotarget 8:8, pages 13375-13386.
Crossref
Neha Jariwala, Bernice Benoit, Andrew V. Kossenkov, Landon K. Oetjen, Timothy M. Whelan, Christine M. Cornejo, Junko Takeshita, Brian S. Kim, Louise C. Showe, Maria Wysocka & Alain H. Rook. (2017) TIGIT and Helios Are Highly Expressed on CD4+ T Cells in Sézary Syndrome Patients. Journal of Investigative Dermatology 137:1, pages 257-260.
Crossref
Karsten Mahnke & Alexander H. Enk. (2016) TIGIT-CD155 Interactions in Melanoma: A Novel Co-Inhibitory Pathway with Potential for Clinical Intervention. Journal of Investigative Dermatology 136:1, pages 9-11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.