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OncoImmunology Volume 5, 2016 - Issue 2
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Original Research

Expression of inhibitory receptors on intratumoral T cells modulates the activity of a T cell-bispecific antibody targeting folate receptor

Jens SchreinerLaboratory of Cancer Immunology, Department of Biomedicine, Basel, Switzerland
,
Daniela S. ThommenLaboratory of Cancer Immunology, Department of Biomedicine, Basel, Switzerland;Department of Medical Oncology, University Hospital Basel, Basel, Switzerland
,
Petra HerzigLaboratory of Cancer Immunology, Department of Biomedicine, Basel, Switzerland
,
Marina BacacRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland
,
Christian KleinRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland
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Andreas RollerRoche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Innovation Center Penzberg, Penzberg, Germany
,
Anton BelousovRoche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Innovation Center Penzberg, Penzberg, Germany
,
Victor LevitskyRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland
,
Spasenija SavicInstitute of Pathology, University Hospital Basel, Basel, Switzerland
,
Wolfgang MoersigDepartment of Surgery, University Hospital Basel, Basel, Switzerland
,
Franziska UhlenbrockLaboratory of Cancer Immunology, Department of Biomedicine, Basel, Switzerland
,
Viola A. Heinzelmann-SchwarzDepartment of Gynecology and Obstetrics, University Hospital Basel, Basel, Switzerland
,
Pablo UmanaRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland
,
Pavel PisaRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland
,
M. von Bergwelt-BaildonKlinik I für Innere Medizin, Klinikum der Universitäat zu Köln, Germany
,
Didier LardinoisDepartment of Surgery, University Hospital Basel, Basel, Switzerland
,
Philipp MüllerLaboratory of Cancer Immunology, Department of Biomedicine, Basel, Switzerland
,
Vaios KaranikasRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland
&
Alfred ZippeliusLaboratory of Cancer Immunology, Department of Biomedicine, Basel, Switzerland;Department of Medical Oncology, University Hospital Basel, Basel, SwitzerlandCorrespondence[email protected]
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Article: e1062969 | Received 30 Apr 2015, Accepted 10 Jun 2015, Published online: 26 Feb 2016

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Daniel Snell, Tea Gunde, Stefan Warmuth, Bithi Chatterjee, Matthias Brock, Christian Hess, Maria Johansson, Alexandre Simonin, Fabio Mario Spiga, Christopher Weinert, Niels Kirk, Nicole Bassler, Lucia Campos Carrascosa, Naomi Flückiger, Robin Heiz, Sandro Wagen, Noreen Giezendanner, Alessandra Alberti, Yasemin Yaman, Dana Mahler, Dania Diem, Peter Lichtlen & David Urech. (2023) An engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin. OncoImmunology 12:1.
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Articles from other publishers (22)

Yanan Wu, Meng Yuan, Chenlin Wang, Yanfei Chen, Yan Zhang & Jiandong Zhang. (2023) T lymphocyte cell: A pivotal player in lung cancer. Frontiers in Immunology 14.
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Guanghui Xu, Yuting Luo, Hanbing Wang, Yue Wang, Baorui Liu & Jia Wei. (2022) Therapeutic bispecific antibodies against intracellular tumor antigens. Cancer Letters 538, pages 215699.
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Yuki Noguchi, Yoko Yamamoto, Kota Iwahori, Mitsunobu Matsumoto, Michinari Hirata, Hiroomi Okuyama, Yasushi Shintani, Atsushi Kumanogoh & Hisashi Wada. (2022) Tetracyclines Enhance Anti-tumor T-Cell Responses Induced by a Bispecific T-Cell Engager. Biological and Pharmaceutical Bulletin 45:4, pages 429-437.
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Daisuke Kamakura, Ryutaro Asano & Masahiro Yasunaga. (2021) T Cell Bispecific Antibodies: An Antibody-Based Delivery System for Inducing Antitumor Immunity. Pharmaceuticals 14:11, pages 1172.
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V.H. Koelzer, P. Herzig, I. Zlobec, V. Heinzelmann, D. Lardinois, E. Walseng, C. Rader, K.D. Mertz, A. Zippelius & D.S. Thommen. (2021) Integrated functional and spatial profiling of tumour immune responses induced by immunotherapy: the iPROFILER platform. Immuno-Oncology and Technology 10, pages 100034.
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Jim Middelburg, Kristel Kemper, Patrick Engelberts, Aran F. Labrijn, Janine Schuurman & Thorbald van Hall. (2021) Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors. Cancers 13:2, pages 287.
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Johannes Sam, Sara Colombetti, Tanja Fauti, Andreas Roller, Marlene Biehl, Linda Fahrni, Valeria Nicolini, Mario Perro, Tapan Nayak, Esther Bommer, Anne Schoenle, Maria Karagianni, Marine Le Clech, Nathalie Steinhoff, Christian Klein, Pablo Umaña & Marina Bacac. (2020) Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity. Frontiers in Oncology 10.
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Marta Trüb, Franziska Uhlenbrock, Christina Claus, Petra Herzig, Martin Thelen, Vaios Karanikas, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Gieri Cathomas, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Christian Klein, Heinz Laubli, Abhishek S Kashyap & Alfred Zippelius. (2020) Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer. Journal for ImmunoTherapy of Cancer 8:2, pages e000238.
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Heliang Li, Phei Er Saw & Erwei Song. (2020) Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics. Cellular & Molecular Immunology 17:5, pages 451-461.
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Yoko Yamamoto, Kota Iwahori, Soichiro Funaki, Mitsunobu Matsumoto, Michinari Hirata, Tetsuya Yoshida, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Masato Minami, Eiichi Sato, Atsushi Kumanogoh, Yasushi Shintani, Meinoshin Okumura & Hisashi Wada. (2020) Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors. Scientific Reports 10:1.
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Kota Iwahori. 2020. Tumor Microenvironment. Tumor Microenvironment 53 62 .
Claire Coeshott, Boah Vang, Mark Jones & Brian Nankervis. (2019) Large-scale expansion and characterization of CD3+ T-cells in the Quantum® Cell Expansion System. Journal of Translational Medicine 17:1.
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Junpeng Qi, David Hymel, Christopher G. Nelson, Terrence R. BurkeJr.Jr. & Christoph Rader. (2019) Conventional and Chemically Programmed Asymmetric Bispecific Antibodies Targeting Folate Receptor 1. Frontiers in Immunology 10.
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Shaun M. O'Brien, Astero Klampatsa, Jeffrey C. Thompson, Marina C. Martinez, Wei-Ting Hwang, Abishek S. Rao, Jason E. Standalick, Soyeon Kim, Edward Cantu, Leslie A. Litzky, Sunil Singhal, Evgeniy B. Eruslanov, Edmund K. Moon & Steven M. Albelda. (2019) Function of Human Tumor-Infiltrating Lymphocytes in Early-Stage Non–Small Cell Lung Cancer. Cancer Immunology Research 7:6, pages 896-909.
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Kota Iwahori, Yasushi Shintani, Soichiro Funaki, Yoko Yamamoto, Mitsunobu Matsumoto, Tetsuya Yoshida, Akiko Morimoto-Okazawa, Atsunari Kawashima, Eiichi Sato, Stephen Gottschalk, Meinoshin Okumura, Atsushi Kumanogoh & Hisashi Wada. (2019) Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment. Scientific Reports 9:1.
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Batoul Farran, Eluri Pavitra, Prameswari Kasa, Sujatha Peela, Ganji Seeta Rama Raju & Ganji Purnachandra Nagaraju. (2019) Folate-targeted immunotherapies: Passive and active strategies for cancer. Cytokine & Growth Factor Reviews 45, pages 45-52.
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Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj & Johannes vom Berg. (2018) Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy. Frontiers in Oncology 8.
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Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christian Klein, Vaios Karanikas, Kirsten D. Mertz, Ton N. Schumacher & Alfred Zippelius. (2018) A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Nature Medicine 24:7, pages 994-1004.
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Daniela S. Thommen & Ton N. Schumacher. (2018) T Cell Dysfunction in Cancer. Cancer Cell 33:4, pages 547-562.
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Chengyun Yan, Jiwei Gu, Hongying Jing, Jinghua Taishi & Robert J. Lee. (2017) Tat-Tagged and Folate-Modified N -Succinyl-chitosan (Tat-Suc-FA) Self-assembly Nanoparticle for Therapeutic Delivery OGX-011 to A549 Cells . Molecular Pharmaceutics 14:6, pages 1898-1905.
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Fa Yang, Weihong Wen & Weijun Qin. (2016) Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies. International Journal of Molecular Sciences 18:1, pages 48.
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Even Walseng, Christopher G. Nelson, Junpeng Qi, Alex R. Nanna, William R. Roush, Rajib K. Goswami, Subhash.C. Sinha, Terrence R. BurkeJr.Jr. & Christoph Rader. (2016) Chemically Programmed Bispecific Antibodies in Diabody Format. Journal of Biological Chemistry 291:37, pages 19661-19673.
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