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OncoImmunology Volume 5, 2016 - Issue 8
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Original Research

Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling

Danfeng SunDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA;State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China
,
Yanwei LinDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA;State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China
,
Jie HongState Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China
,
Haoyan ChenState Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China
,
Nisha NagarshethDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA;Graduate Programs in Immunology, University of Michigan School of Medicine, Ann Arbor, MI, USA
,
Dongjun PengDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
,
Shuang WeiDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
,
Emina HuangDepartment of Colorectal Surgery, Cleveland Clinic, Western Reserve University, Cleveland, OH, USA
,
Jingyuan FangState Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China
,
Ilona KryczekDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USACorrespondence[email protected] [email protected]
&
Weiping ZouDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA;Graduate Programs in Immunology, University of Michigan School of Medicine, Ann Arbor, MI, USA;Tumor Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA;The University of Michigan Comprehensive Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, USACorrespondence[email protected] [email protected]
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Article: e1082704 | Received 10 Jun 2015, Accepted 08 Aug 2015, Published online: 25 Aug 2016

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Mehmet Saydam, Kerim Bora Yilmaz, Mutlu Sahin, Hamdullah Yanik, Melih Akinci, Ibrahim Yilmaz, Sener Balas, Cem Azili & Mehmet Ali Gulcelik. (2021) New Findings on Autoimmune Etiology of Idiopathic Granulomatous Mastitis: Serum IL-17, IL-22 and IL-23 Levels of Patients. Journal of Investigative Surgery 34:9, pages 993-997.
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Tanzeela Arshad, Fizzah Mansur, Richard Palek, Sobia Manzoor & Vaclav Liska. (2020) A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration. Frontiers in Immunology 11.
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William Becker, Haider Rasheed Alrafas, Kiesha Wilson, Kathryn Miranda, Courtney Culpepper, Ioulia Chatzistamou, Guoshuai Cai, Mitzi Nagarkatti & Prakash S. Nagarkatti. (2020) Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production. iScience 23:9, pages 101504.
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Soheil Tavakolpour & Mohammad Darvishi. 2020. Cancer Immunology. Cancer Immunology 63 90 .
Guanglin Cui. (2019) TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer. Frontiers in Oncology 9.
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Franco R. D’Alessio, Johanna T. Kurzhagen & Hamid Rabb. (2019) Reparative T lymphocytes in organ injury. Journal of Clinical Investigation 129:7, pages 2608-2618.
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Xiuru Ying, Ranran Pan, Jie Zhong, Boyi Wu, Yuting Jiang, Jieer Ying, Cong Zhou, Jie Dai, Shuangying Zhao, Yinan Shen, Wei Zhang & Shiwei Duan. (2019) Significant association of EED promoter hypomethylation with colorectal cancer. Oncology Letters.
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Alessandro Poggi, Roberto Benelli, Roberta Venè, Delfina Costa, Nicoletta Ferrari, Francesca Tosetti & Maria Raffaella Zocchi. (2019) Human Gut-Associated Natural Killer Cells in Health and Disease. Frontiers in Immunology 10.
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Xu Chen, Zhi‐feng Lin, Wen‐jin Xi, Wei Wang, Dan Zhang, Fan Yang, Yu‐fang Li, Yi Huo, Tian‐ze Zhang, Yi‐hong Jiang, Wei‐wei Qin, An‐gang Yang & Tao Wang. (2019) DNA methylation‐regulated and tumor‐suppressive roles of miR‐487b in colorectal cancer via targeting MYC, SUZ12, and KRAS. Cancer Medicine 8:4, pages 1694-1709.
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Gianluca D'Agostino, Valentina Cecchinato & Mariagrazia Uguccioni. (2018) Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity. Frontiers in Immunology 9.
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Nasim Khosravi, Mauricio S. Caetano, Amber M. Cumpian, Nese Unver, Cynthia De la Garza Ramos, Oscar Noble, Soudabeh Daliri, Belinda J. Hernandez, Berenice A. Gutierrez, Scott E. Evans, Samir Hanash, Andrei M. Alekseev, Yi Yang, Seon Hee Chang, Roza Nurieva, Humam Kadara, Jichao Chen, Edwin J. Ostrin & Seyed Javad Moghaddam. (2018) IL22 Promotes Kras -Mutant Lung Cancer by Induction of a Protumor Immune Response and Protection of Stemness Properties . Cancer Immunology Research 6:7, pages 788-797.
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Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo & Chen Jianping. (2018) The Imbalance between Foxp3 + Tregs and Th1/Th17/Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis . Journal of Immunology Research 2018, pages 1-12.
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Nisha Nagarsheth, Max S. Wicha & Weiping Zou. (2017) Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nature Reviews Immunology 17:9, pages 559-572.
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Leonie Brockmann, Anastasios Giannou, Nicola Gagliani & Samuel Huber. (2017) Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis. International Journal of Molecular Sciences 18:5, pages 1033.
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Mirna Perusina Lanfranca, Yanwei Lin, Jingyuan Fang, Weiping Zou & Timothy Frankel. (2016) Biological and pathological activities of interleukin-22. Journal of Molecular Medicine 94:5, pages 523-534.
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