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OncoImmunology Volume 5, 2016 - Issue 3
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Review

IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?

Jakub TomalaLaboratory of Tumor Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
&
Marek KovarLaboratory of Tumor Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech RepublicCorrespondence[email protected]
Article: e1102829 | Received 02 Sep 2015, Accepted 28 Sep 2015, Published online: 21 Mar 2016

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Claire Vanpouille-Box, Claire Lhuillier, Lucillia Bezu, Fernando Aranda, Takahiro Yamazaki, Oliver Kepp, Jitka Fucikova, Radek Spisek, Sandra Demaria, Silvia C. Formenti, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2017) Trial watch: Immune checkpoint blockers for cancer therapy. OncoImmunology 6:11.
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Articles from other publishers (13)

Okki Cho, Joong-Woon Lee, Young-Jin Jeong, Lee Kyung Kim, Bo-Kyung Jung & Tae-Hwe Heo. (2024) Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma. European Journal of Pharmacology 962, pages 176239.
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Veronika Niederlova, Oksana Tsyklauri, Marek Kovar & Ondrej Stepanek. (2023) IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy. Trends in Immunology 44:11, pages 890-901.
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Pravin B. Sehgal. (2022) Interleukin-6 at the Host-Tumor Interface: STAT3 in Biomolecular Condensates in Cancer Cells. Cells 11:7, pages 1164.
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Rui Guan, Qiong Lyu, Anqi Lin, Junyi Liang, Weimin Ding, Manming Cao, Peng Luo & Jian Zhang. (2021) Influence of Different Age Cutoff Points on the Prediction of Prognosis of Cancer Patients Receiving ICIs and Potential Mechanistic Exploration. Frontiers in Oncology 11.
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Nina Zila, Christoph Hoeller & Verena Paulitschke. (2021) Novel immune checkpoints beyond PD-1 in advanced melanoma. memo - Magazine of European Medical Oncology 14:2, pages 135-142.
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Ayushi Singh, Kunal Dhume, Joanne D. Tejero, Tara M. Strutt & K. Kai McKinstry. (2020) CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer’s Patches. Scientific Reports 10:1.
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Dominik Hrabos, Tereza Hnizdilova, Jakub Tomala, Jiri Uhlik & Marek Kovar. (2020) IL-7/αIL-7 mAb M25 immunocomplexes expand CD8+ T cells but paradoxically abrogate the antitumor activity of CTLA-4 and PD-1 blockage. Cytokine 133, pages 155174.
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Fahmida Alam, Ayushi Singh, Valeria Flores-Malavet, Stewart Sell, Andrea M. Cooper, Susan L. Swain, K. Kai McKinstry & Tara M. Strutt. (2020) CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation. The Journal of Immunology, pages ji2000205.
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Julian A. Marin-Acevedo, Bhagirathbhai Dholaria, Aixa E. Soyano, Keith L. Knutson, Saranya Chumsri & Yanyan Lou. (2018) Next generation of immune checkpoint therapy in cancer: new developments and challenges. Journal of Hematology & Oncology 11:1.
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Julian A. Marin-Acevedo, Aixa E. Soyano, Bhagirathbhai Dholaria, Keith L. Knutson & Yanyan Lou. (2018) Cancer immunotherapy beyond immune checkpoint inhibitors. Journal of Hematology & Oncology 11:1.
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Isaac J. Jensen, Christina S. Winborn, Micaela G. Fosdick, Peng Shao, Mikaela M. Tremblay, Qiang Shan, Sandeep Kumar Tripathy, Christopher M. Snyder, Hai-Hui Xue, Thomas S. Griffith, Jon C. Houtman & Vladimir P. Badovinac. (2018) Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLOS Pathogens 14:10, pages e1007405.
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Loek J. Eggermont, Roel Hammink, Kerstin G. Blank, Alan E. Rowan, Jurjen Tel & Carl G. Figdor. (2018) Cytokine-Functionalized Synthetic Dendritic Cells for T Cell Targeted Immunotherapies. Advanced Therapeutics 1:6, pages 1800021.
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Inês T. Simões, Fernando Aranda, Esther Carreras, Maria Velasco-de Andrés, Sergi Casadó-Llombart, Vanesa G. Martinez & Francisco Lozano. (2017) Immunomodulatory effects of soluble CD5 on experimental tumor models. Oncotarget 8:64, pages 108156-108169.
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