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OncoImmunology Volume 5, 2016 - Issue 5
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Original Research

TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models

Myriam LamraniEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, France
,
Nejia SassiEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, France
,
Catherine PaulEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, France
,
Nadhir YousfiEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France
,
Jean-Luc BoucherUMR 8601 CNRS, Paris Descartes University, Paris, France
,
Nolwenn GauthierEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;INSERM U 866, Burgundy University, Dijon, France
,
Jérôme LabbéEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;INSERM U 866, Burgundy University, Dijon, France
,
Cédric SeignezEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, France
,
Cindy RacoeurEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, France
,
Anne AthiasINSERM U 866, Burgundy University, Dijon, France
,
Romain GuerreiroBioGéoSciences UMR 6282, Burgundy University, Dijon, France
,
Catherine VergelyINSERM U 866, Burgundy University, Dijon, France
,
Luc RochetteINSERM U 866, Burgundy University, Dijon, France
,
Ali BettaiebEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, FranceCorrespondence[email protected]
&
Jean-François JeanninEPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France;Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France;INSERM U 866, Burgundy University, Dijon, France
 show all
Article: e1123369 | Received 02 Oct 2015, Accepted 17 Nov 2015, Published online: 29 Apr 2016

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Christian Karime, Jing Wang, Gregory Woodhead, Kabir Mody, Charles T. Hennemeyer, Mitesh J. Borad, Daruka Mahadevan, Sreenivasa R. Chandana & Hani Babiker. (2022) Tilsotolimod: an investigational synthetic toll-like receptor 9 (TLR9) agonist for the treatment of refractory solid tumors and melanoma. Expert Opinion on Investigational Drugs 31:1, pages 1-13.
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Zhaoche Shu, Jun Yuan, Hong Wang, Jinghui Zhang, Sijie Li, Hong Zhang, Yusi Liu, Yibing Yin & Xuemei Zhang. (2020) Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2/4 dependent manner. Virulence 11:1, pages 270-282.
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Lu Li, Jiongwei Pan, Xiaoping Cai, Enhui Gong, Cunlai Xu, Hao Zheng, Zhuo Cao & Zhangyong Yin. (2020) Human umbilical cord mesenchymal stem cells suppress lung cancer via TLR4/NF-κB signalling pathway. Biotechnology & Biotechnological Equipment 34:1, pages 24-29.
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Shoujin Jiang, Wei Fu, Sijia Wang, Guanshu Zhu, Jufang Wang & Yi Ma. (2023) Bacterial Outer Membrane Vesicles Loaded with Perhexiline Suppress Tumor Development by Regulating Tumor-Associated Macrophages Repolarization in a Synergistic Way. International Journal of Molecular Sciences 24:13, pages 11222.
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Nesrine Mabrouk, Cindy Racoeur, Jingxuan Shan, Aurélie Massot, Silvia Ghione, Malorie Privat, Lucile Dondaine, Elise Ballot, Caroline Truntzer, Romain Boidot, François Hermetet, Valentin Derangère, Mélanie Bruchard, Frédérique Végran, Lotfi Chouchane, François Ghiringhelli, Ali Bettaieb & Catherine Paul. (2023) GTN Enhances Antitumor Effects of Doxorubicin in TNBC by Targeting the Immunosuppressive Activity of PMN-MDSC. Cancers 15:12, pages 3129.
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Huihui Ding, Gongfu Wang, Zhen Yu, Huimin Sun & Lu Wang. (2022) Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway. Biomedicine & Pharmacotherapy 155, pages 113683.
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Zhangfeng Zhong, Chi Teng Vong, Feiyu Chen, Horyue Tan, Cheng Zhang, Ning Wang, Liao Cui, Yitao Wang & Yibin Feng. (2022) Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets. Medicinal Research Reviews 42:3, pages 1246-1279.
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Amina Ghouzlani, Abdelhakim Lakhdar, Soumaya Rafii, Mehdi Karkouri & Abdallah Badou. (2021) The immune checkpoint VISTA exhibits high expression levels in human gliomas and associates with a poor prognosis. Scientific Reports 11:1.
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Inesa Navasardyan & Benjamin Bonavida. (2021) Regulation of T Cells in Cancer by Nitric Oxide. Cells 10:10, pages 2655.
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Nesrine Mabrouk, Silvia Ghione, Véronique Laurens, Stéphanie Plenchette, Ali Bettaieb & Catherine Paul. (2020) Senescence and Cancer: Role of Nitric Oxide (NO) in SASP. Cancers 12:5, pages 1145.
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Lizdany Flórez-Álvarez, Lanie Ruiz-Perez, Natalia Taborda & Juan C Hernandez. (2020) Toll-like receptors as a therapeutic target in cancer, infections and inflammatory diseases. Immunotherapy 12:5, pages 311-322.
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Ana Patricia Ayala‐Cuellar, Jaejin Cho & Kyung‐Chul Choi. (2019) Toll‐like receptors: A pathway alluding to cancer control. Journal of Cellular Physiology 234:12, pages 21707-21715.
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Morteza Khademalhosseini & Mohammad Kazemi Arababadi. (2018) Toll-like receptor 4 and breast cancer: an updated systematic review. Breast Cancer 26:3, pages 265-271.
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Amandine Martin, Cédric Seignez, Cindy Racoeur, Nicolas Isambert, Nesrine Mabrouk, Alessandra Scagliarini, Sylvie Reveneau, Laurent Arnould, Ali Bettaieb, Jean-François Jeannin & Catherine Paul. (2018) Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment. Oncotarget 9:47, pages 28364-28378.
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Blake Alan Scott, Mark YarchoanElizabeth M. Jaffee. (2018) Prophylactic Vaccines for Nonviral Cancers. Annual Review of Cancer Biology 2:1, pages 195-211.
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Bahar Salimian Rizi, Abhinav Achreja & Deepak Nagrath. (2017) Nitric Oxide: The Forgotten Child of Tumor Metabolism. Trends in Cancer 3:9, pages 659-672.
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Samira Khabbazi, Nan Xie, Wenjun Pu, Yannick Goumon & Marie-Odile Parat. (2016) The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro. Frontiers in Pharmacology 7.
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