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OncoImmunology Volume 5, 2016 - Issue 8
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Original Research

PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine

Shamaila Munir AhmadCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark
,
Evelina MartinenaiteCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark
,
Morten HansenCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark
,
Niels JunkerDepartment of Oncology, Copenhagen University Hospital, Herlev, Denmark
,
Troels Holz BorchCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark;Department of Oncology, Copenhagen University Hospital, Herlev, Denmark
,
Özcan MetCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark;Department of Oncology, Copenhagen University Hospital, Herlev, Denmark
,
Marco DoniaCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark;Department of Oncology, Copenhagen University Hospital, Herlev, Denmark
,
Inge Marie SvaneCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark;Department of Oncology, Copenhagen University Hospital, Herlev, Denmark
&
Mads Hald AndersenCenter for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark;Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
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Article: e1202391 | Received 20 Apr 2016, Accepted 12 Jun 2016, Published online: 11 Aug 2016

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Edda Blümel, Shamaila Munir Ahmad, Claudia Nastasi, Andreas Willerslev-Olsen, Maria Gluud, Simon Fredholm, Tengpeng Hu, Bas G. J. Surewaard, Lise M. Lindahl, Hanne Fogh, Sergei B. Koralov, Lise Mette Rahbek Gjerdrum, Rachael A. Clark, Lars Iversen, Thorbjørn Krejsgaard, Charlotte Menné Bonefeld, Carsten Geisler, Jürgen C. Becker, Anders Woetmann, Mads Hald Andersen, Terkild Brink Buus & Niels Ødum. (2020) Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. OncoImmunology 9:1.
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Morten Orebo Holmström, Caroline Hasselbalch Riley, Vibe Skov, Inge Marie Svane, Hans Carl Hasselbalch & Mads Hald Andersen. (2018) Spontaneous T-cell responses against the immune check point programmed-death-ligand 1 (PD-L1) in patients with chronic myeloproliferative neoplasms correlate with disease stage and clinical response. OncoImmunology 7:6.
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Articles from other publishers (25)

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Yunchao Zhang, Chenxin Liu, Chunjie Wu & Linjiang Song. (2023) Natural peptides for immunological regulation in cancer therapy: Mechanism, facts and perspectives. Biomedicine & Pharmacotherapy 159, pages 114257.
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Mads Hald Andersen. (2022) Tumor microenvironment antigens. Seminars in Immunopathology 45:2, pages 253-264.
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J. Tobias, P. Steinberger, M. Drinić & U. Wiedermann. (2021) Emerging targets for anticancer vaccination: PD-1. ESMO Open 6:5, pages 100278.
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Ming Wu, Sheng Wang, Jian-Yu Chen, Li-Juan Zhou, Zi-Wen Guo & Yu-Hua Li. (2021) Therapeutic cancer vaccine therapy for acute myeloid leukemia. Immunotherapy 13:10, pages 863-877.
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Morten Orebo Holmström, Rasmus Erik Johansson Mortensen, Angelos Michail Pavlidis, Evelina Martinenaite, Stine Emilie Weis-Banke, Mia Aaboe-Jørgensen, Simone Kloch Bendtsen, Özcan Met, Ayako Wakatsuki Pedersen, Marco Donia, Inge Marie Svane & Mads Hald Andersen. (2021) Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner. Cellular & Molecular Immunology 18:2, pages 415-426.
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Pottayil G. Sasikumar & Murali Ramachandra. (2020) Peptide and peptide-inspired checkpoint inhibitors: Protein fragments to cancer immunotherapy. Medicine in Drug Discovery 8, pages 100073.
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Nicolai Grønne Jørgensen, Uffe Klausen, Jacob Handlos Grauslund, Carsten Helleberg, Thomas Granum Aagaard, Trung Hieu Do, Shamaila Munir Ahmad, Lars Rønn Olsen, Tobias Wirenfeldt Klausen, Marie Fredslund Breinholt, Morten Hansen, Evelina Martinenaite, Özcan Met, Inge Marie Svane, Lene Meldgaard Knudsen & Mads Hald Andersen. (2020) Peptide Vaccination Against PD-L1 With IO103 a Novel Immune Modulatory Vaccine in Multiple Myeloma: A Phase I First-in-Human Trial. Frontiers in Immunology 11.
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Mie Linder Hübbe, Ditte Elisabeth Jæhger, Thomas Lars Andresen & Mads Hald Andersen. (2020) Leveraging Endogenous Dendritic Cells to Enhance the Therapeutic Efficacy of Adoptive T-Cell Therapy and Checkpoint Blockade. Frontiers in Immunology 11.
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Morten Orebo Holmström, Hans Carl Hasselbalch & Mads Hald Andersen. (2020) Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms. Cancers 12:7, pages 1763.
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Gholamreza Rezaei Danbaran, Saeed Aslani, Nadia Sharafkandi, Maryam Hemmatzadeh, Ramin Hosseinzadeh, Gholamreza Azizi, Farhad Jadidi-Niaragh, Farhad Babaie & Hamed Mohammadi. (2020) How microRNAs affect the PD-L1 and its synthetic pathway in cancer. International Immunopharmacology 84, pages 106594.
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Mingming Li, Xinran Zhao, Jianfang Dai & Zhilin Yu. (2019) Peptide therapeutics and assemblies for cancer immunotherapy多肽药物及组装体在癌症免疫治疗中的应用. Science China Materials 62:11, pages 1759-1781.
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Weizhi Wang & Zhiyuan Hu. (2018) Targeting Peptide‐Based Probes for Molecular Imaging and Diagnosis. Advanced Materials 31:45, pages 1804827.
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Mads Hald Andersen. (2018) The T-win® technology: immune-modulating vaccines. Seminars in Immunopathology 41:1, pages 87-95.
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Morten Orebo Holmström & Hans Carl Hasselbalch. (2018) Cancer immune therapy for myeloid malignancies: present and future. Seminars in Immunopathology 41:1, pages 97-109.
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Uffe Klausen, Staffan Holmberg, Morten Orebo Holmström, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Inge Marie Svane & Mads Hald Andersen. (2018) Novel Strategies for Peptide-Based Vaccines in Hematological Malignancies. Frontiers in Immunology 9.
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Mads Hald Andersen. (2018) The Balance Players of the Adaptive Immune System. Cancer Research 78:6, pages 1379-1382.
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Nyanbol Kuol, Lily Stojanovska, Kulmira Nurgali & Vasso Apostolopoulos. (2018) PD-1/PD-L1 in disease. Immunotherapy 10:2, pages 149-160.
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Zijun Y. Xu-MonetteJianfeng Zhou & Ken H. Young. (2018) PD-1 expression and clinical PD-1 blockade in B-cell lymphomas. Blood 131:1, pages 68-83.
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Zijun Y. Xu-Monette, Mingzhi Zhang, Jianyong Li & Ken H. Young. (2017) PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?. Frontiers in Immunology 8.
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Katerina Vavrova, Petra Vrabcova, Dominik Filipp, Jirina Bartunkova & Rudolf Horvath. (2016) Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy. Medical Oncology 33:12.
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