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OncoImmunology Volume 6, 2017 - Issue 3
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Original research

IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment in melanoma

Lloyd BodInserm, U1016, Institut Cochin, Paris, France;Cnrs, UMR8104, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, Paris, France
,
Renée LengagneInserm, U1016, Institut Cochin, Paris, France;Cnrs, UMR8104, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, Paris, France
,
Ludovic WrobelHôpitaux Universitaires de Genève, Genève, Switzerland
,
Jan Philipp RamspottInserm, U1016, Institut Cochin, Paris, France;Cnrs, UMR8104, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, Paris, France
,
Masashi KatoNagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
,
Marie-Françoise AvrilInserm, U1016, Institut Cochin, Paris, France;Cnrs, UMR8104, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, Paris, France;APHP, Hôpital Cochin, Paris, France
,
Flavia CastellanoINSERM, U955, Equipe 09, Créteil, France;Université Paris Est, Faculté de Médecine, Créteil, France;AP-HP, Hôpital H. Mondor - A. Chenevier, Plateforme de Ressources Biologiques, Créteil, France
,
Valérie Molinier-FrenkelINSERM, U955, Equipe 09, Créteil, France;Université Paris Est, Faculté de Médecine, Créteil, France;AP-HP, Hôpital H. Mondor - A. Chenevier, Service d'Immunologie Biologique, Créteil, France
&
Armelle Prévost-BlondelInserm, U1016, Institut Cochin, Paris, France;Cnrs, UMR8104, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceCorrespondence[email protected]
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Article: e1278331 | Received 22 Nov 2016, Accepted 28 Dec 2016, Published online: 03 Mar 2017

Citations (20)

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Flavia Castellano, Armelle Prevost-Blondel, José L. Cohen & Valérie Molinier-Frenkel. (2021) What role for AHR activation in IL4I1-mediated immunosuppression ?. OncoImmunology 10:1.
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Tao Xu, Jiahao Liu, Yu Xia, Zhi Wang, Xingrui Li & Qinglei Gao. (2021) Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis. Annals of Medicine 53:1, pages 916-928.
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Articles from other publishers (18)

Tong Li, Jie Shi, Longlong Wang, Xuan Qin, Rui Zhou, Ming Dong, Fan Ren, Xin Li, Zihe Zhang, Yanan Chen, Yanhua Liu, Yongjun Piao, Yi Shi, Song Xu, Jun Chen & Jia Li. (2023) Thymol targeting interleukin 4 induced 1 expression reshapes the immune microenvironment to sensitize the immunotherapy in lung adenocarcinoma. MedComm 4:5.
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Fany Blanc, Nicolas Bertho, Guillaume Piton, Jean-Jacques Leplat, Giorgia Egidy, Emmanuelle Bourneuf, Silvia Vincent-Naulleau & Armelle Prévost-Blondel. (2023) Deciphering the immune reaction leading to spontaneous melanoma regression: initial role of MHCII+ CD163− macrophages. Cancer Immunology, Immunotherapy.
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Liying Zhu, Jun Wang & Jia’an Hu. (2023) High expression of IL4I1 is correlated with poor prognosis and immune infiltration in thyroid cancer. BMC Endocrine Disorders 23:1.
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Leonie Zeitler & Peter J. Murray. (2023) IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer. Journal of Biological Chemistry 299:6, pages 104827.
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Gourav Chandan, Adesh K. Saini, Reena Kumari, Sasanka Chakrabarti, Amit Mittal, Anil Kumar Sharma & Reena V. Saini. (2022) The exploitation of enzyme-based cancer immunotherapy. Human Cell 36:1, pages 98-120.
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Dean Rao, Chengpeng Yu, Tiantian Wang, Jiaqi Sheng, Enjun Lv, Huifang Liang, Wenjie Huang & Hanhua Dong. (2022) Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker. International Immunopharmacology 111, pages 109091.
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Marie-Line Puiffe, Aurélie Dupont, Nouhoum Sako, Jérôme Gatineau, José L. Cohen, Denis Mestivier, Agnès Lebon, Armelle Prévost-Blondel, Flavia Castellano & Valérie Molinier-Frenkel. (2020) IL4I1 Accelerates the Expansion of Effector CD8+ T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation. Frontiers in Immunology 11.
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Xia Zhang, Min Gan, Jingyun Li, Hui Li, Meicheng Su, Dongfei Tan, Shaolei Wang, Man Jia, Liguo Zhang & Gang Chen. (2020) Endogenous Indole Pyruvate Pathway for Tryptophan Metabolism Mediated by IL4I1. Journal of Agricultural and Food Chemistry 68:39, pages 10678-10684.
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Erandi A. Serrano-Carbajal, Jesús Espinal-Enríquez & Enrique Hernández-Lemus. (2020) Targeting Metabolic Deregulation Landscapes in Breast Cancer Subtypes. Frontiers in Oncology 10.
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Marc Presset, Diana Djordjevic, Aurélie Dupont, Erwan Le Gall, Valérie Molinier-Frenkel & Flavia Castellano. (2020) Identification of inhibitors of the immunosuppressive enzyme IL4I1. Bioorganic Chemistry 94, pages 103463.
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Valérie Molinier-Frenkel, Armelle Prévost-Blondel & Flavia Castellano. (2019) The IL4I1 Enzyme: A New Player in the Immunosuppressive Tumor Microenvironment. Cells 8:7, pages 757.
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Denny Miley Cárdenas, Angie Carolina Sánchez, Daris Angélica Rosas, Esmeralda Rivero, Massiel Dayana Paparoni, Mildred Andreína Cruz, Yeicy Paola Suárez & Nestor Fabián Galvis. (2018) Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer. BMC Gastroenterology 18:1.
Crossref
Katarzyna Szołtysek, Patryk Janus, Gracjana Zając, Tomasz Stokowy, Anna Walaszczyk, Wiesława Widłak, Bartosz Wojtaś, Bartłomiej Gielniewski, Simon Cockell, Neil D. Perkins, Marek Kimmel & Piotr Widlak. (2018) RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation. BMC Genomics 19:1.
Crossref
Jan Philipp Ramspott, Fériel Bekkat, Lloyd Bod, Maryline Favier, Benoit Terris, Anne Salomon, Lounes Djerroudi, Kurt S. Zaenker, Yolande Richard, Valérie Molinier-Frenkel, Flavia Castellano, Marie-Françoise Avril & Armelle Prévost-Blondel. (2018) Emerging Role of IL-4–Induced Gene 1 as a Prognostic Biomarker Affecting the Local T-Cell Response in Human Cutaneous Melanoma. Journal of Investigative Dermatology 138:12, pages 2625-2634.
Crossref
Lloyd Bod, Laetitia Douguet, Cédric Auffray, Renée Lengagne, Fériel Bekkat, Elena Rondeau, Valérie Molinier-Frenkel, Flavia Castellano, Yolande Richard & Armelle Prévost-Blondel. (2018) IL-4–Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation. The Journal of Immunology 200:3, pages 1027-1038.
Crossref
Aude Aubatin, Nouhoum Sako, Xavier Decrouy, Emmanuel Donnadieu, Valérie Molinier-Frenkel & Flavia Castellano. (2018) IL4-induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity. European Journal of Immunology 48:1, pages 106-119.
Crossref
Flavia Castellano & Valérie Molinier-Frenkel. (2017) An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1. Molecules 22:12, pages 2151.
Crossref
Valérie Molinier‐Frenkel & Flavia Castellano. (2017) Immunosuppressive enzymes in the tumor microenvironment. FEBS Letters 591:19, pages 3135-3157.
Crossref

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