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OncoImmunology Volume 6, 2017 - Issue 6
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Original Research

Chemotherapeutic tumor microparticles combining low-dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway

Yanling SunDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Zu'an ZhengDepartment of Cancer, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Huafeng ZhangDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Yuandong YuDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Jingwei MaDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Ke TangDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Pingwei XuDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Tiantian JiDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Xiaoyu LiangDepartment of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Degao ChenDepartment of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Xun JinDepartment of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Tianzhen ZhangDepartment of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Zhixiong LongDepartment of Oncology, the Fifth Hospital of Wuhan, Wuhan, Hubei, China
,
Yuying LiuDepartment of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China
&
Bo HuangDepartment of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Immunology, Institute of Basic Medical Sciences & State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, ChinaCorrespondence[email protected]
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Article: e1309487 | Received 28 Dec 2016, Accepted 15 Mar 2017, Published online: 19 May 2017

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Shuangli Zhu, Shiyu Li, Ming Yi, Ning Li & Kongming Wu. (2021) Roles of Microvesicles in Tumor Progression and Clinical Applications. International Journal of Nanomedicine 16, pages 7071-7090.
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Articles from other publishers (25)

Laiyan Zhou, Yuanxin Liu, Yuanjun Wu, Xue Yang, Feng‐Ming Spring Kong, You Lu & Jianxin Xue. (2023) Low‐dose radiation therapy mobilizes antitumor immunity: New findings and future perspectives. International Journal of Cancer.
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Weiwei Sun, Pingwei Xu, Pengtao Pan, Sheng Guo, Rui Liu, Guojie Ji, Huanhuan Hu, Weidong Li & Lili Dai. (2023) Application of tumor microparticles in tumor prevention and treatment. Cancer Nanotechnology 14:1.
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Weiwei Sun, Lili Dai, Yuqing Cao, Pengtao Pan, Lijuan Zhi, Xinke Wang, Xinzhong Yuan, Zi Gao, Sheng Guo, Guoyan Liu, Junlei Yin, Liangliang Xie, Liping Wang, Yanling Wang, Wensheng Li, Hong Li & Yunjie Jia. (2023) Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development. Cancer Nanotechnology 14:1.
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Zhengyang Hu, Xing Jin, Weifeng Hong, Qihai Sui, Mengnan Zhao, Yiwei Huang, Ming Li, Qun Wang, Cheng Zhan & Zhencong Chen. (2023) Dissecting the single-cell transcriptome network of macrophage and identifies a signature to predict prognosis in lung adenocarcinoma. Cellular Oncology 46:5, pages 1351-1368.
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Yujian Teng, Licheng Xu, Wenjing Li, Pengyan Liu, Linli Tian & Ming Liu. (2023) Targeting reactive oxygen species and fat acid oxidation for the modulation of tumor-associated macrophages: a narrative review. Frontiers in Immunology 14.
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Shuya Lu, Qingfa Cui, Huan Zheng, Yuan Ma, Yanchun Kang & Ke Tang. (2023) Challenges and Opportunities for Extracellular Vesicles in Clinical Oncology Therapy. Bioengineering 10:3, pages 325.
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Xiao Hu, Li Yu, Yuan Bian, Xiaonan Zeng, Shan Luo, Qinglian Wen & Ping Chen. (2023) Paclitaxel-loaded tumor cell-derived microparticles improve radiotherapy efficacy in triple-negative breast cancer by enhancing cell killing and stimulating immunity. International Journal of Pharmaceutics 632, pages 122560.
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Sijia Zhang, Leichong Chen, Yan Zong, Qianwen Li, Kuikui Zhu, Zhenyu Li & Rui Meng. (2022) Research progress of tumor‐derived extracellular vesicles in the treatment of malignant pleural effusion. Cancer Medicine 12:2, pages 983-994.
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Yan Hu, Yajie Sun, Chao Wan, Xiaomeng Dai, Shuhui Wu, Pui-Chi Lo, Jing Huang, Jonathan F. Lovell, Honglin Jin & Kunyu Yang. (2022) Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research. Journal of Nanobiotechnology 20:1.
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Xiaorong Dong, Yu Huang, Tienan Yi, Chunhong Hu, Quanli Gao, Yuan Chen, Jing Zhang, Jianhua Chen, Li Liu, Rui Meng, Sheng Zhang, Xiaofang Dai, Shihong Fei, Yang Jin, Ping Yin, Yanping Hu & Gang Wu. (2022) Intrapleural infusion of tumor cell-derived microparticles packaging methotrexate or saline combined with pemetrexed-cisplatin chemotherapy for the treatment of malignant pleural effusion in advanced non-squamous non-small cell lung cancer: A double-blind, randomized, placebo-controlled study. Frontiers in Immunology 13.
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Yu Liu, Sufei Wang, Hui Xia, Xueyun Tan, Siwei Song, Shujing Zhang, Daquan Meng, Qing Chen & Yang Jin. (2022) The potential applications of microparticles in the diagnosis, treatment, and prognosis of lung cancer. Journal of Translational Medicine 20:1.
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Zhenfeng Wang, Shunshun Li & Bo Huang. (2022) Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection. Signal Transduction and Targeted Therapy 7:1.
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Xiaojuan Hou, Wenting Liu, Xue Yang, Changchun Shao, Lu Gao, Li Zhang & Lixin Wei. (2022) Extracellular microparticles derived from hepatic progenitor cells deliver a death signal to hepatoma-initiating cells. Journal of Nanobiotechnology 20:1.
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Zhenfeng Wang, Jiadi Lv, Pin Yu, Yajin Qu, Yabo Zhou, Li Zhou, Qiangqiang Zhu, Shunshun Li, Jiangping Song, Wei Deng, Ran Gao, Yuying Liu, Jiangning Liu, Wei-Min Tong, Chuan Qin & Bo Huang. (2022) SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cellular & Molecular Immunology 19:2, pages 210-221.
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Weijian Lin & Xing-Dong Cai. (2021) Current Strategies for Cancer Cell-Derived Extracellular Vesicles for Cancer Therapy. Frontiers in Oncology 11.
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Yuping Liu, Rongping Fu, Shumei Tu, Ding Qu, Congyan Liu, Xiaoqi Li, Yang Zhao, Chengyao Ma, Yan Chen & Li Tao. (2021) Extracellular Microparticles Encapsulated with Diallyl Trisulfide Interfere with the Inflammatory Tumor Microenvironment and Lung Metastasis of Invasive Melanoma. Molecular Pharmaceutics 18:3, pages 822-835.
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Liping Xu, Xiaoli Xie & Ying Luo. (2021) The role of macrophage in regulating tumour microenvironment and the strategies for reprogramming tumour-associated macrophages in antitumour therapy. European Journal of Cell Biology 100:2, pages 151153.
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Daiqing Wei, Cui Li, Junwu Ye, Feifan Xiang, Yangbo Xu & Juncai Liu. (2020) Codelivery of survivin inhibitor and chemotherapeutics by tumor‐derived microparticles to reverse multidrug resistance in osteosarcoma. Cell Biology International 45:2, pages 382-393.
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Jingwei Ma, Huafeng Zhang, Ke Tang & Bo Huang. (2020) Tumor‐derived microparticles in tumor immunology and immunotherapy. European Journal of Immunology 50:11, pages 1653-1662.
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Linlin Shi, Jianyong Sheng, Guozhong Chen, Peng Zhu, Changping Shi, Bei Li, Chaiwoo Park, Jingyi Wang, Bixiang Zhang, Zhi Liu & Xiangliang Yang. (2020) Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance. Journal for ImmunoTherapy of Cancer 8:2, pages e000973.
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Pingwei Xu, Ke Tang, Jingwei Ma, Huafeng Zhang, Dianheng Wang, Liyan Zhu, Jie Chen, Keke Wei, Jincheng Liu, Haiqing Fang, Liang Tang, Yi Zhang, Jing Xie, Yuying Liu, Rui Meng, Li Liu, Xiaorong Dong, Kunyu Yang, Gang Wu, Fei Ma & Bo Huang. (2020) Chemotherapeutic Tumor Microparticles Elicit a Neutrophil Response Targeting Malignant Pleural Effusions. Cancer Immunology Research 8:9, pages 1193-1205.
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Limei Yin, Jianxin Xue, Rui Li, Lin Zhou, Lei Deng, Lin Chen, Yan Zhang, Yanying Li, Xuanwei Zhang, Weigang Xiu, Ruizhan Tong, Youling Gong, Meijuan Huang, Yong Xu, Jiang Zhu, Min Yu, Mengqian Li, Jie Lan, Jin Wang, Xianming Mo, Yuquan Wei, Gabriele Niedermann & You Lu. (2020) Effect of Low-Dose Radiation Therapy on Abscopal Responses to Hypofractionated Radiation Therapy and Anti-PD1 in Mice and Patients With Non-Small Cell Lung Cancer. International Journal of Radiation Oncology*Biology*Physics 108:1, pages 212-224.
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Yunfeng Gao, Hui Zhang, Nannan Zhou, Pingwei Xu, Jianxiong Wang, Yuan Gao, Xun Jin, Xiaoyu Liang, Jiadi Lv, Yamin Zhang, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Fang Yao, Weimin Tong, Yuying Liu, Ximo Wang & Bo Huang. (2020) Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nature Biomedical Engineering 4:7, pages 743-753.
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Hongjuan Zhao, Beibei Zhao, Lixia Wu, Huifang Xiao, Kaili Ding, Cuixia Zheng, Qingling Song, Lingling Sun, Lei Wang & Zhenzhong Zhang. (2019) Amplified Cancer Immunotherapy of a Surface-Engineered Antigenic Microparticle Vaccine by Synergistically Modulating Tumor Microenvironment. ACS Nano 13:11, pages 12553-12566.
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Sara Musetti & Leaf Huang. (2018) Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy. ACS Nano 12:12, pages 11740-11755.
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