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OncoImmunology Volume 6, 2017 - Issue 5
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Original Research

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

Dipti VijayanImmunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Deborah S. BarkauskasImmunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Kimberley StannardImmunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Erin SultMedImmune, LLC., Gaithersburg, MD, USA
,
Rebecca BuonpaneMedImmune, LLC., Gaithersburg, MD, USA
,
Kazuyoshi TakedaDivision of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, JapanORCID Iconhttp://orcid.org/0000-0002-5539-310X
ORCID Icon,
Michele W. L. TengCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Kris SachsenmeierAstraZeneca, PLC, Waltham, MA, USA
,
Carl HayMedImmune, LLC., Gaithersburg, MD, USA
&
Mark J. SmythImmunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, University of Queensland, Herston, Queensland, AustraliaCorrespondence[email protected]
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Article: e1312044 | Received 15 Feb 2017, Accepted 23 Mar 2017, Published online: 08 May 2017

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Miles Congreve, Giles A. Brown, Alexandra Borodovsky & Michelle L. Lamb. (2018) Targeting adenosine A2A receptor antagonism for treatment of cancer. Expert Opinion on Drug Discovery 13:11, pages 997-1003.
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Articles from other publishers (19)

Hannah S. Sperber, Kyle A. Raymond, Mohamed S. Bouzidi, Tongcui Ma, Silvana Valdebenito, Eliseo A. Eugenin, Nadia R. Roan, Steven G. Deeks, Sandra Winning, Joachim Fandrey, Roland Schwarzer & Satish K. Pillai. (2023) The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency. Cell Reports 42:11, pages 113285.
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Niklas Bach, Riekje Winzer, Eva Tolosa, Walter Fiedler & Franziska Brauneck. (2023) The Clinical Significance of CD73 in Cancer. International Journal of Molecular Sciences 24:14, pages 11759.
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Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen & Ligong Lu. (2023) Review immune response of targeting CD39 in cancer. Biomarker Research 11:1.
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Andrea M. Chambers, Jiao Wang, Tram N. Dao, Kyle B. Lupo, Paige Veenhuis, Mitchell G. Ayers, Veronika Slivova, Aaron A. Cohen-Gadol & Sandro Matosevic. (2022) Functional expression of CD73 on human natural killer cells. Cancer Immunology, Immunotherapy 71:12, pages 3043-3056.
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Huihui Ding, Gongfu Wang, Zhen Yu, Huimin Sun & Lu Wang. (2022) Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway. Biomedicine & Pharmacotherapy 155, pages 113683.
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Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren WK Hansen, Morten F Gjerstorff, Christa E Müller, Paul WHI Parren & Henrik J Ditzel. (2022) Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity. Journal for ImmunoTherapy of Cancer 10:9, pages e004554.
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Mikkel G. Terp, Odd L. Gammelgaard, Henriette Vever, Morten F. Gjerstorff & Henrik J. Ditzel. (2021) Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes. Molecular Oncology 15:12, pages 3299-3316.
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Macus Hao-Ran Bao & Carmen Chak-Lui Wong. (2021) Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer. Cells 10:7, pages 1715.
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James E. Stefano, Dana M. Lord, Yanfeng Zhou, Julie Jaworski, Joern Hopke, Tara Travaline, Ningning Zhang, Karen Wong, Amanda Lennon, Timothy He, Eva Bric-Furlong, Cornishia Cherrie, Tristan Magnay, Elisabeth Remy, William Brondyk, Huawei Qiu & Katarina Radošević. (2020) A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms. Journal of Biological Chemistry 295:52, pages 18379-18389.
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Alice Mogenet, Pascale Tomasini, Laurent Greillier & Fabrice Barlesi. (2020) Toxicités à prévoir avec les futures immunothérapies ou associations. Bulletin du Cancer 107:10, pages 1069-1078.
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Angela Ostuni, Monica Carmosino, Rocchina Miglionico, Vittorio Abruzzese, Fabio Martinelli, Daniela Russo, Ilaria Laurenzana, Agata Petillo & Faustino Bisaccia. (2020) Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway. Cells 9:6, pages 1410.
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Shi Yong Neo, Ying Yang, Julien Record, Ran Ma, Xinsong Chen, Ziqing Chen, Nicholas P. Tobin, Emily Blake, Christina Seitz, Ron Thomas, Arnika Kathleen Wagner, John Andersson, Jana de Boniface, Jonas Bergh, Shannon Murray, Evren Alici, Richard Childs, Martin Johansson, Lisa S. Westerberg, Felix Haglund, Johan Hartman & Andreas Lundqvist. (2020) CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment. Journal of Clinical Investigation 130:3, pages 1185-1198.
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Simone de Leve, Florian Wirsdörfer & Verena Jendrossek. (2019) The CD73/Ado System—A New Player in RT Induced Adverse Late Effects. Cancers 11:10, pages 1578.
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Zheng Qiao, Xiaoping Li, Nannan Kang, Yue Yang, Chuyuan Chen, Tao Wu, Mingjun Zhao, Yu Liu & Xuemei Ji. (2019) A Novel Specific Anti-CD73 Antibody Inhibits Triple-Negative Breast Cancer Cell Motility by Regulating Autophagy. International Journal of Molecular Sciences 20:5, pages 1057.
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Xin Chen, Xiaomin Song, Kang Li & Tong Zhang. (2019) FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy. Frontiers in Immunology 10.
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David Allard, Pavel Chrobak, Bertrand Allard, Nouredin Messaoudi & John Stagg. (2019) Targeting the CD73-adenosine axis in immuno-oncology. Immunology Letters 205, pages 31-39.
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Kavitha Gowrishankar, Lucy Birtwistle & Kenneth Micklethwaite. (2018) Manipulating the tumor microenvironment by adoptive cell transfer of CAR T-cells. Mammalian Genome 29:11-12, pages 739-756.
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Dipti Vijayan, Arabella Young, Michele W.L. Teng & Mark J. Smyth. (2017) Targeting immunosuppressive adenosine in cancer. Nature Reviews Cancer 17:12, pages 709-724.
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