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Original Research

Tumor cells PD-L1 expression as a favorable prognosis factor in nasopharyngeal carcinoma patients with pre-existing intratumor-infiltrating lymphocytes

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Article: e1312240 | Received 24 Feb 2017, Accepted 24 Mar 2017, Published online: 08 May 2017

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Crossref
Soehartati A. Gondhowiardjo, Handoko, Marlinda Adham, Lisnawati Rachmadi, Henry Kodrat, Demak Lumban Tobing, I. Made Haryoga, Agustinus Gatot Dwiyono, Yoseph Adi Kristian & Tiara Bunga Mayang Permata. (2020) Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer. PLOS ONE 15:3, pages e0230449.
Crossref
Xin-Lin He, Ying Zhou, Huan-Zi Lu, Qun-Xing Li & Zhi Wang. (2020) Prognostic value of VISTA in solid tumours: a systematic review and meta-analysis. Scientific Reports 10:1.
Crossref
Qian Zhu, Ai-Lin Zhong, Hao Hu, Jing-Jing Zhao, De-Sheng Weng, Yan Tang, Qiu-Zhong Pan, Zi-Qi Zhou, Meng-Jia Song, Jie-Ying Yang, Jun-Yi He, Yuan Liu, Min Li, Wan-Ming Hu, Chao-Pin Yang, Tong Xiang, Ming-Yuan Chen, Gang Ma, Ling Guo & Jian-Chuan Xia. (2020) Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma. Journal of Hematology & Oncology 13:1.
Crossref
Hayriye Sahinli, Nalan Akyürek, Mukaddes Yılmaz, Olcay Kandemir, AyşeOcak Duran, Sezer Kulaçoǧlu, Gökhan Uçar, Elif Acar, Ahmet Özet, ÖBerna Ç. Öksüzoǧlu & NuriyeY Özdemir. (2020) Good prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells. Journal of Cancer Research and Therapeutics 0:0, pages 0.
Crossref
Hayriye Sahinli, Nalan Akyürek, Mukaddes Yılmaz, Olcay Kandemir, AyşeOcak Duran, Sezer Kulaçoğlu, Gökhan Uçar, Elif Acar, Ahmet Özet, Mahmut Gümüş, ÖBerna Ç. Öksüzoğlu & NuriyeY Özdemir. (2020) PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma. Indian Journal of Cancer 0:0, pages 0.
Crossref
Ya-Qin Wang, Yu Zhang, Wei Jiang, Yu-Pei Chen, Shuo-Yu Xu, Na Liu, Yin Zhao, Li Li, Yuan Lei, Xiao-Hong Hong, Ye-Lin Liang, Jun-Yan Li, Lu-Lu Zhang, Jing-Ping Yun, Ying Sun, Ying-Qin Li & Jun Ma. (2019) Development and validation of an immune checkpoint-based signature to predict prognosis in nasopharyngeal carcinoma using computational pathology analysis. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
Yu-Li Chen, Han-Wei Lin, Chung-Liang Chien, Yen-Ling Lai, Wei-Zen Sun, Chi-An Chen & Wen-Fang Cheng. (2019) BTLA blockade enhances Cancer therapy by inhibiting IL-6/IL-10-induced CD19high B lymphocytes. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
Jia-Wei Lv, Jun-Yan Li, Lin-Na Luo, Zi-Xian Wang & Yu-Pei Chen. (2019) Comparative safety and efficacy of anti-PD-1 monotherapy, chemotherapy alone, and their combination therapy in advanced nasopharyngeal carcinoma: findings from recent advances in landmark trials. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
Zi-Lu Huang, Shan Liu, Guan-Nan Wang, Shuo-Han Zheng, Shi-Rong Ding, Ya-lan Tao, Chen Chen, Song-Ran Liu, Xin Yang, Hui Chang, Xiao-Hui Wang & Yun-Fei Xia. (2019) The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis. Cancer Cell International 19:1.
Crossref
Chang-Ying Guo, Qian Zhu, Fang-Fang Tou, Xiao-Ming Wen, Yu-Kang Kuang & Hao Hu. (2019) The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma. BMC Cancer 19:1.
Crossref
Christoph Minichsdorfer, Felicitas Oberndorfer, Christoph Krall, Gabriela Kornek, Leonhard Müllauer, Christina Wagner & Thorsten Fuereder. (2019) PD-L1 Expression on Tumor Cells Is Associated With a Poor Outcome in a Cohort of Caucasian Nasopharyngeal Carcinoma Patients. Frontiers in Oncology 9.
Crossref
Xiaofeng Liu, Chunguang Shan, Yingluan Song & Juan Du. (2019) Prognostic Value of Programmed Cell Death Ligand-1 Expression in Nasopharyngeal Carcinoma: A Meta-Analysis of 1,315 Patients. Frontiers in Oncology 9.
Crossref
Yu-Pei Chen, Anthony T C Chan, Quynh-Thu Le, Pierre Blanchard, Ying Sun & Jun Ma. (2019) Nasopharyngeal carcinoma. The Lancet 394:10192, pages 64-80.
Crossref
Yi-Qun Jia, Bo Yang, Li-Ling Wen, Wen-Xin Mu, Zhi Wang & Bin Cheng. (2019) Prognostic value of immune checkpoint molecules in head and neck cancer: a meta-analysis. Aging 11:2, pages 501-522.
Crossref
Yu-Jen Liu, Ngan-Ming Tsang, Chuen Hsueh, Chi-Ju Yeh, Shir-Hwa Ueng, Tong-Hong Wang & Wen-Yu Chuang. (2018) Low PD-L1 Expression Strongly Correlates with Local Recurrence in Epstein-Barr Virus-Positive Nasopharyngeal Carcinoma after Radiation-Based Therapy. Cancers 10:10, pages 374.
Crossref
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Crossref
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Crossref
Brigette B.Y. MaWan-Teck LimBoon-Cher GohEdwin P. HuiKwok-Wai LoAdam PettingerNathan R. FosterJonathan W. RiessMark AgulnikAlex Y.C. ChangAkhil ChopraJulie A. KishChristine H. ChungDouglas R. AdkinsKevin J. CullenBarbara J. GitlitzDean W. LimKa-Fai ToK.C. Allen ChanY.M. Dennis LoAnn D. KingCharles ErlichmanJun YinBrian A. CostelloAnthony T.C. Chan. (2018) Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742). Journal of Clinical Oncology 36:14, pages 1412-1418.
Crossref
Marie-Emilie Dourthe, Stéphanie Bolle, Stéphane Temam, Anais Jouin, Line Claude, Yves Reguerre, Anne-Sophie Defachelles, Daniel Orbach & Brice Fresneau. (2018) Childhood Nasopharyngeal Carcinoma: State-of-the-Art, and Questions for the Future. Journal of Pediatric Hematology/Oncology 40:2, pages 85-92.
Crossref

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