2,020
Views
41
CrossRef citations to date
0
Altmetric
Original Research

Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

, , , , , , , , , , & show all
Article: e1314425 | Received 27 Mar 2017, Accepted 28 Mar 2017, Published online: 16 May 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Dong Won Baek, Juhyung Kim, Hee Jeong Cho, Joon Ho Moon & Sang Kyun Sohn. (2020) Hypomethylating agent-based post-transplant strategies to maximize the outcome of high-risk acute myeloid leukemia after allogeneic stem cell transplantation. Expert Review of Hematology 13:9, pages 959-969.
Read now

Articles from other publishers (40)

Jane Chuprin, Hannah Buettner, Mina O. Seedhom, Dale L. Greiner, James G. Keck, Fumihiko Ishikawa, Leonard D. Shultz & Michael A. Brehm. (2023) Humanized mouse models for immuno-oncology research. Nature Reviews Clinical Oncology 20:3, pages 192-206.
Crossref
Caroline Ritacco, Murat Cem Köse, Justine Courtois, Lorenzo Canti, Charline Beguin, Sophie Dubois, Benoît Vandenhove, Sophie Servais, Jo Caers, Yves Beguin, Grégory Ehx & Frédéric Baron. (2023) Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells. iScience 26:3, pages 106085.
Crossref
Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin & Hsing-Chen Tsai. (2023) Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities. Journal of Biomedical Science 30:1.
Crossref
Frédéric Baron, Myriam Labopin, Johanna Tischer, Fabio Ciceri, Anna Maria Raiola, Didier Blaise, Simona Sica, Jan Vydra, Renato Fanin, Jose Luis Diez-Martin, Claude Eric Bulabois, Friedrich Stölzel, Alessandro Busca, Pavel Jindra, Yener Koc, Patrice Chevallier, Edouard Forcade, Wolf Rösler, Jakob Passweg, Alexander Kulagin, Angelo Michele Carella, Celestine Simand, Ali Bazarbachi, Pietro Pioltelli, Arnon Nagler & Mohamad Mohty. (2022) Comparison of HLA-mismatched unrelated donor transplantation with post-transplant cyclophosphamide versus HLA-haploidentical transplantation in patients with active acute myeloid leukemia. Bone Marrow Transplantation 57:11, pages 1657-1663.
Crossref
Amal Elhage, Chloe Sligar, Peter Cuthbertson, Debbie Watson & Ronald Sluyter. (2022) Insights into mechanisms of graft-versus-host disease through humanised mouse models. Bioscience Reports 42:9.
Crossref
Seyed Mostafa Monzavi, Ahad Muhammadnejad, Maryam Behfar, Amir Arsalan Khorsand, Samad Muhammadnejad & Abdol‐Mohammad Kajbafzadeh. (2022) Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions . Animal Models and Experimental Medicine 5:4, pages 389-396.
Crossref
Kevin-James Wattebled, Elodie Drumez, Valérie Coiteux, Léonardo Magro, Micha Srour, Paul Chauvet, Bruno Quesnel, Alain Duhamel, Ibrahim Yakoub-Agha & David Beauvais. (2022) Single-agent 5-azacytidine as post-transplant maintenance in high-risk myeloid malignancies undergoing allogeneic hematopoietic cell transplantation. Annals of Hematology 101:6, pages 1321-1331.
Crossref
Sophie Servais, Yves Beguin & Frédéric Baron. (2022) Current Status and Perspectives of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia. Stem Cells Translational Medicine 11:5, pages 461-477.
Crossref
Michael C. Zaiken, Ryan FlynnKatelyn G. PazStephanie Y. RheeSujeong Jin, Fathima A. Mohamed, Asim SahaGovindarajan ThangaveluPaul M. C. ParkMatthew L. HemmingPeter T. SageArlene H. SharpeMichel DuPage, Jeffrey A. BluestoneAngela Panoskaltsis-MortariCorey S. CutlerJohn KorethJoseph H. AntinRobert J. SoifferJerome Ritz, Leo LuznikIvan MaillardGeoffrey R. HillKelli P. A. MacDonaldDavid H. MunnJonathan S. SerodyWilliam J. MurphyLeslie S. KeanYi ZhangJames E. Bradner, Jun Qi & Bruce R. Blazar. (2022) BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood 139:19, pages 2983-2997.
Crossref
Jonathan A. Webster, Leo Luznik & Ivana Gojo. (2021) Treatment of AML Relapse After Allo-HCT. Frontiers in Oncology 11.
Crossref
Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries & Hans J. P. M. Koenen. (2021) Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review. Journal of Translational Medicine 19:1.
Crossref
Justine Courtois, Caroline Ritacco, Sophie Dubois, Lorenzo Canti, Benoît Vandenhove, Laurence Seidel, Coline Daulne, Jo Caers, Sophie Servais, Yves Beguin, Grégory Ehx & Frédéric Baron. (2021) Itacitinib prevents xenogeneic GVHD in humanized mice. Bone Marrow Transplantation 56:11, pages 2672-2681.
Crossref
Yun Wang, Min Wang, Hao‐Xiang Wu & Rui‐Hua Xu. (2021) Advancing to the era of cancer immunotherapy. Cancer Communications 41:9, pages 803-829.
Crossref
Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Katrina M. Bird, Stephen J. Fuller, Debbie Watson & Ronald Sluyter. (2021) Purinergic Signalling in Allogeneic Haematopoietic Stem Cell Transplantation and Graft-versus-Host Disease. International Journal of Molecular Sciences 22:15, pages 8343.
Crossref
Grégory Ehx, Caroline Ritacco, Muriel Hannon, Sophie Dubois, Loic Delens, Evelyne Willems, Sophie Servais, Pierre Drion, Yves Beguin & Frédéric Baron. (2021) Comprehensive analysis of the immunomodulatory effects of rapamycin on human T cells in graft‐versus‐host disease prophylaxis. American Journal of Transplantation 21:8, pages 2662-2674.
Crossref
Chenchen Zhao, Yi Zhang & Hong Zheng. (2021) The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations. Frontiers in Immunology 12.
Crossref
Lukas M. Braun & Robert Zeiser. (2021) Immunomodulatory Therapies for the Treatment of Graft-versus-host Disease. HemaSphere 5:6, pages e581.
Crossref
Jianyu Chen, Honghao Zhang, Lijuan Zhou, Yuxing Hu, Meifang Li, Yanjie He & Yuhua Li. (2021) Enhancing the Efficacy of Tumor Vaccines Based on Immune Evasion Mechanisms. Frontiers in Oncology 10.
Crossref
Arnon Nagler, Frédéric Baron, Myriam Labopin, Emmanuel Polge, Jordi Esteve, Ali Bazarbachi, Eolia Brissot, Gesine Bug, Fabio Ciceri, Sebastian Giebel, Maria H. Gilleece, Norbert-Claude Gorin, Francesco Lanza, Zinaida Peric, Annalisa Ruggeri, Jaime Sanz, Bipin N. Savani, Christoph Schmid, Roni Shouval, Alexandros Spyridonidis, Jurjen Versluis & Mohamad Mohty. (2020) Measurable residual disease (MRD) testing for acute leukemia in EBMT transplant centers: a survey on behalf of the ALWP of the EBMT. Bone Marrow Transplantation 56:1, pages 218-224.
Crossref
Benoît Vandenhove, Lorenzo Canti, Hélène Schoemans, Yves Beguin, Frédéric Baron, Carlos Graux, Tessa Kerre & Sophie Servais. (2020) How to Make an Immune System and a Foreign Host Quickly Cohabit in Peace? The Challenge of Acute Graft-Versus-Host Disease Prevention After Allogeneic Hematopoietic Cell Transplantation. Frontiers in Immunology 11.
Crossref
Alicia Li, Ciril Abraham, Ying Wang & Yi Zhang. (2020) New insights into the basic biology of acute graft-versus-host-disease. Haematologica 105:11, pages 2540-2549.
Crossref
Kiyomi Mashima, Morio Azuma, Ken Fujiwara, Takeshi Inagaki, Iekuni Oh, Takashi Ikeda, Kento Umino, Hirofumi Nakano, Kaoru Morita, Kazuya Sato, Daisuke Minakata, Ryoko Yamasaki, Masahiro Ashizawa, Chihiro Yamamoto, Shin-Ichiro Fujiwara, Kaoru Hatano, Ken Ohmine, Kazuo Muroi, Nobuhiko Ohno & Yoshinobu Kanda. (2020) Differential Localization and Invasion of Tumor Cells in Mouse Models of Human and Murine Leukemias. ACTA HISTOCHEMICA ET CYTOCHEMICA 53:3, pages 43-53.
Crossref
Carolina Marini, Eolia Brissot, Abdulhamid Bazarbachi, Rémy Duléry, Simona Sestili, Giorgia Battipaglia, Clémence Médiavilla, Annalisa Paviglianiti, Ramdane Belhocine, Francoise Isnard, Simona Lapusan, Rosa Adaeva, Anne Bannet, Zoé van de Wiegert, Anne Vekhoff, Tounes Ledraa, Ollivier Legrand, Myriam Labopin, Agnes Bonnin, Annalisa Ruggeri, Florent Malard & Mohamad Mohty. (2020) Tolerability and Efficacy of Treatment With Azacytidine as Prophylactic or Preemptive Therapy for Myeloid Neoplasms After Allogeneic Stem Cell Transplantation. Clinical Lymphoma Myeloma and Leukemia 20:6, pages 377-382.
Crossref
Melinda A. Biernacki, Vipul S. Sheth & Marie Bleakley. (2020) T cell optimization for graft-versus-leukemia responses. JCI Insight 5:9.
Crossref
Frédéric Baron, Myriam Labopin, Bipin N. Savani, Eric Beohou, Dietger Niederwieser, Matthias Eder, Victoria Potter, Nicolaus Kröger, Dietrich Beelen, Gerard Socié, Maija Itälä‐Remes, Martin Bornhäuser, Mohamad Mohty & Arnon Nagler. (2019) Graft‐versus‐host disease and graft‐versus‐leukaemia effects in secondary acute myeloid leukaemia: a retrospective, multicentre registry analysis from the Acute Leukaemia Working Party of the EBMT. British Journal of Haematology 188:3, pages 428-437.
Crossref
Shlomo Elias & Alexander Y. Rudensky. (2019) Therapeutic use of regulatory T cells for graft‐versus‐host disease. British Journal of Haematology 187:1, pages 25-38.
Crossref
Yufeng Shang & Fuling Zhou. (2019) Current Advances in Immunotherapy for Acute Leukemia: An Overview of Antibody, Chimeric Antigen Receptor, Immune Checkpoint, and Natural Killer. Frontiers in Oncology 9.
Crossref
Nicholas J. Geraghty, Lisa Belfiore, Sam R. Adhikary, Stephen I. Alexander, Ronald Sluyter & Debbie Watson. (2019) Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice. Transplant Immunology 54, pages 38-46.
Crossref
Céline Grégoire, Caroline Ritacco, Muriel Hannon, Laurence Seidel, Loïc Delens, Ludovic Belle, Sophie Dubois, Sophie Vériter, Chantal Lechanteur, Alexandra Briquet, Sophie Servais, Gregory Ehx, Yves Beguin & Frédéric Baron. (2019) Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model. Frontiers in Immunology 10.
Crossref
F. Baron, M. Labopin, A. Ruggeri, F. Volt, M. Mohty, D. Blaise, P. Chevallier, J. Sanz, N. Fegueux, J. J. Cornelissen, A. Rambaldi, B. N. Savani, E. Gluckman & A. Nagler. (2019) Cord blood transplantation is associated with good outcomes in secondary Acute Myeloid Leukaemia in first remission. Journal of Internal Medicine 285:4, pages 446-454.
Crossref
N.J. Geraghty, D. Watson & R. Sluyter. (2019) Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease. Cellular Immunology 336, pages 12-19.
Crossref
Loïc Delens, Grégory Ehx, Joan Somja, Louise Vrancken, Ludovic Belle, Laurence Seidel, Céline Grégoire, Gilles Fransolet, Caroline Ritacco, Muriel Hannon, Sophie Dubois, Yves Beguin, Frédéric Baron & Sophie Servais. (2019) In Vitro Th17-Polarized Human CD4+ T Cells Exacerbate Xenogeneic Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation 25:2, pages 204-215.
Crossref
Helen Loo Yau, Ilias Ettayebi & Daniel D. De Carvalho. (2019) The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy. Trends in Cell Biology 29:1, pages 31-43.
Crossref
Ying-Jun Chang, Xiang-Yu Zhao & Xiao-Jun Huang. (2018) Strategies for Enhancing and Preserving Anti-leukemia Effects Without Aggravating Graft-Versus-Host Disease. Frontiers in Immunology 9.
Crossref
P Achita, D Dervovic, D Ly, J B Lee, T Haug, B Joe, N Hirano & L Zhang. (2018) Infusion of ex-vivo expanded human TCR-αβ+ double-negative regulatory T cells delays onset of xenogeneic graft- versus -host disease . Clinical and Experimental Immunology 193:3, pages 386-399.
Crossref
Grégory Ehx, Joan Somja, Hans-Jörg Warnatz, Caroline Ritacco, Muriel Hannon, Loïc Delens, Gilles Fransolet, Philippe Delvenne, Joséphine Muller, Yves Beguin, Hans Lehrach, Ludovic Belle, Stéphanie Humblet-Baron & Frédéric Baron. (2018) Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice. Frontiers in Immunology 9.
Crossref
Christian Flotho, Sebastian Sommer & Michael Lübbert. (2018) DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia. Seminars in Cancer Biology 51, pages 68-79.
Crossref
Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, Jan J. Cornelissen, Ellen Meijer, Henrik Sengeloev, Dietger Niederwieser, Marco R. De Groot, Harry C. Schouten, Noel Milpied, Didier Blaise, Bipin N. Savani, Eliane Gluckman, Mohamad Mohty & Arnon Nagler. (2018) Impact of Donor Type in Patients with AML Given Allogeneic Hematopoietic Cell Transplantation After Low-Dose TBI-Based Regimen. Clinical Cancer Research 24:12, pages 2794-2803.
Crossref
F. Baron, A. Ruggeri, E. Beohou, M. Labopin, M. Mohty, J. Sanz, S. Vigouroux, S. Furst, A. Bosi, P. Chevallier, J. J. Cornelissen, M. Michallet, J. Sierra, D. Karakasis, B. N. Savani, E. Gluckman & A. Nagler. (2018) Occurrence of graft-versus-host disease increases mortality after umbilical cord blood transplantation for acute myeloid leukaemia: a report from Eurocord and the ALWP of the EBMT. Journal of Internal Medicine 283:2, pages 178-189.
Crossref
Frédéric Baron, Annalisa Ruggeri, Eric Beohou, Myriam Labopin, Mohamad Mohty, Didier Blaise, Jan J Cornelissen, Patrice Chevallier, Guillermo Sanz, Eefke Petersen, Bipin N Savani, Eliane Gluckman & Arnon Nagler. (2017) Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT. Journal of Hematology & Oncology 10:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.