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OncoImmunology Volume 7, 2018 - Issue 2
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Original Research

Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa

Yichen ChenGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Qiusheng LiGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Xinye LiGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Da MaGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Juan FangGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Liqun LuoZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
,
Xiangqi LiuGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Xi WangGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Vivian Wai Yan LuiSchool of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR
,
Juan XiaGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China
,
Bin ChengGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, ChinaCorrespondence[email protected]
&
Zhi WangGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, ChinaCorrespondence[email protected]
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Article: e1388484 | Received 24 Jul 2017, Accepted 30 Sep 2017, Published online: 06 Nov 2017

Citations (21)

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Liang Feng, Ke Yin, Suxin Zhang, Zhong Chen, Yang Bao & Tianke Li. (2022) Anti-PD-1 Therapy is Beneficial for the Survival of Patients with Oral Squamous Cell Carcinoma. Cancer Management and Research 14, pages 2723-2731.
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Articles from other publishers (20)

Nevena Ladjevac, Marija Milovanovic, Andra Jevtovic, Dragana Arsenijevic, Bojana Stojanovic, Milica Dimitrijevic Stojanovic, Bojan Stojanovic, Nebojsa Arsenijevic, Aleksandar Arsenijevic & Jelena Milovanovic. (2023) The Role of IL-17 in the Pathogenesis of Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences 24:12, pages 9874.
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Andrew R. Reynolds, Michele Moschetta, Alula R. Yohannes, Farzana Walcott, Marianne Ashford, Zoltan Szucs, Tina Sarbajna, James Hadfield, Eden Harrison, Benjamin G. Challis, Amaya Gasco Hernandez, Gaia Schiavon, Caroline Germa, Gyorgy Zorenyi, Barry Crean & Susan Galbraith. (2023) A View on Drug Development for Cancer Prevention. Cancer Discovery 13:5, pages 1058-1083.
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Tianqing Wang, Silu Sun, Xin Zeng & Jing Li. (2023) ICI-based therapies: A new strategy for oral potentially malignant disorders. Oral Oncology 140, pages 106388.
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Chai Phei Gan, Bernard Kok Bang Lee, Shin Hin Lau, Thomas George Kallarakkal, Zuraiza Mohamad Zaini, Bryan Kit Weng Lye, Rosnah Binti Zain, Hans Prakash Sathasivam, Joe Poh Sheng Yeong, Natalia Savelyeva, Gareth Thomas, Christian H. Ottensmeier, Hany Ariffin, Sok Ching Cheong & Kue Peng Lim. (2022) Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia. Frontiers in Immunology 13.
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Wei-Chiao Chiu, Da-Liang Ou & Ching-Ting Tan. (2022) Mouse Models for Immune Checkpoint Blockade Therapeutic Research in Oral Cancer. International Journal of Molecular Sciences 23:16, pages 9195.
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Thomas Duhen, Michael J. Gough, Rom S. Leidner & Sasha E. Stanton. (2022) Development and therapeutic manipulation of the head and neck cancer tumor environment to improve clinical outcomes. Frontiers in Oral Health 3.
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Talha Bin Emran, Asif Shahriar, Aar Rafi Mahmud, Tanjilur Rahman, Mehedy Hasan Abir, Mohd. Faijanur - Rob Siddiquee, Hossain Ahmed, Nova Rahman, Firzan Nainu, Elly Wahyudin, Saikat Mitra, Kuldeep Dhama, Mahmoud M. Habiballah, Shafiul Haque, Ariful Islam & Mohammad Mahmudul Hassan. (2022) Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches. Frontiers in Oncology 12.
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Wenqiang Xie, Jie Shen, Dikan Wang, Junyi Guo, Qunxing Li, Shuqiong Wen, Wenxiao Dai, Liling Wen, Huanzi Lu, Juan Fang & Zhi Wang. (2022) Dynamic changes of exhaustion features in T cells during oral carcinogenesis. Cell Proliferation 55:4.
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Linjun Shi, Yuquan Yang, Mengying Li, Chenxi Li, Zengtong Zhou, Guoyao Tang, Lan Wu, Yilin Yao, Xuemin Shen, Zhaoyuan Hou & Hao Jia. (2022) LncRNA IFITM4P promotes immune escape by up-regulating PD-L1 via dual mechanism in oral carcinogenesis. Molecular Therapy 30:4, pages 1564-1577.
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Roberto Rangel, Curtis R. Pickering, Andrew G. Sikora & Michael T. Spiotto. (2022) Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy. Frontiers in Immunology 13.
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Yewen Shi, Tong-xin Xie, David G. Leach, Bingbing Wang, Simon Young, Abdullah A. Osman, Andrew G. Sikora, Xiaoyong Ren, Jeffrey D. Hartgerink, Jeffrey N. Myers & Roberto Rangel. (2021) Local Anti–PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model. Cancer Prevention Research 14:8, pages 767-778.
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Shan Wang, Xiaorong Yu, Fang Li, Haixia Fan, Eryang Zhao & Zheng Hu. (2021) Targeting IL-17alpha to promote anti-PD-1 therapy effect by screening the tumor immune microenvironment in a mouse oral carcinogenesis model. Cancer Biomarkers 31:4, pages 339-350.
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Nils Ludwig, Łukasz Wieteska, Cynthia S. Hinck, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Richard J. Bauer, Torsten E. Reichert, Andrew P. Hinck & Theresa L. Whiteside. (2021) Novel TGFβ Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti–PD-L1 Immunotherapy. Molecular Cancer Therapeutics 20:6, pages 1102-1111.
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Sara M. Centuori, Carlos Caulin & Julie E. Bauman. (2021) Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention. Current Treatment Options in Oncology 22:6.
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Bohai Feng & Jochen Hess. (2021) Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer. Cancers 13:5, pages 1162.
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Kyle J. Gu & Guojun Li. (2020) An Overview of Cancer Prevention: Chemoprevention and Immunoprevention. Journal of Cancer Prevention 25:3, pages 127-135.
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L. Wen, W. Mu, H. Lu, X. Wang, J. Fang, Y. Jia, Q. Li, D. Wang, S. Wen, J. Guo, W. Dai, X. Ren, J. Cui, G. Zeng, J. Gao, Z. Wang & B. Cheng. (2020) Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment . Journal of Dental Research 99:6, pages 666-675.
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Qiang Li, Heng Dong, Guangwen Yang, Yuxian Song, Yongbin Mou & Yanhong Ni. (2020) Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma. Frontiers in Oncology 10.
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Liling Wen, Huanzi Lu, Qiusheng Li, Qunxing Li, Shuqiong Wen, Dikan Wang, Xi Wang, Juan Fang, Jun Cui, Bin Cheng & Zhi Wang. (2019) Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis. Journal of Experimental & Clinical Cancer Research 38:1.
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Yichen Chen, Xi Wang, Juan Fang, Jingjing Song, Da Ma, Liqun Luo, Bailin He, Juan Xia, Vivian Wai Yan Lui, Bin Cheng & Zhi Wang. (2019) Mesenchymal stem cells participate in oral mucosa carcinogenesis by regulating T cell proliferation. Clinical Immunology 198, pages 46-53.
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