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OncoImmunology Volume 7, 2018 - Issue 2
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Original Research

Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition

Imran SiddiquiDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6792-8730
ORCID Icon,
Marco ErreniDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), ItalyORCID Iconhttps://orcid.org/0000-0002-1922-0818
ORCID Icon,
Mohammad Azhar KamalDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), Italy
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Chiara PortaDepartment of Pharmaceutical Sciences, Università Piemonte Orientale, Novara, ItalyORCID Iconhttps://orcid.org/0000-0002-7183-5561
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Federica MarchesiDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), Italy;Department of Medical Biotechnology and Translational Medicine, University of Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-7212-5721
ORCID Icon,
Samantha PesceDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), Italy
,
Fabio PasqualiniDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), Italy
,
Silvia SchiareaDepartment of Environmental Health Sciences, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, ItalyORCID Iconhttps://orcid.org/0000-0001-7569-4762
ORCID Icon,
Chiara ChiabrandoDepartment of Environmental Health Sciences, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy
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Alberto MantovaniDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), Italy;Humanitas University, Rozzano (Milano), ItalyORCID Iconhttps://orcid.org/0000-0001-5578-236X
ORCID Icon &
Paola AllavenaDepartment of Immunology, IRCCS Clinical and Research Institute Humanitas, Rozzano (Milano), Italy;Humanitas University, Rozzano (Milano), Italy
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Article: e1388485 | Received 29 Aug 2017, Accepted 30 Sep 2017, Published online: 01 Nov 2017

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Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg. (2020) Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology. OncoImmunology 9:1.
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Articles from other publishers (24)

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Heng‐Chung Kung & Jun Yu. (2023) Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study. MedComm 4:2.
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梦珂 聂. (2023) Significance of Ascites Cytology in Early Diagnosis of the Nature of Ovarian Malignancy. Advances in Clinical Medicine 13:04, pages 6496-6501.
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Michelle R. Goulart, Jennifer Watt, Imran Siddiqui, Rita T. Lawlor, Ahmet Imrali, Christine Hughes, Amina Saad, Joanne ChinAleong, Chris Hurt, Catrin Cox, Roberto Salvia, Alberto Mantovani, Tatjana Crnogorac-Jurcevic, Somnath Mukherjee, Aldo Scarpa, Paola Allavena & Hemant M. Kocher. (2021) Pentraxin 3 is a stromally-derived biomarker for detection of pancreatic ductal adenocarcinoma. npj Precision Oncology 5:1.
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Weiliang Jiang, Congying Chen, Li Huang, Jie Shen & Lijuan Yang. (2021) GATA4 Regulates Inflammation-Driven Pancreatic Ductal Adenocarcinoma Progression. Frontiers in Cell and Developmental Biology 9.
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Chunlei Yang, Binna Zhu, Shijie Ye, Zhengwei Fu & Jinjun Li. (2021) Isomer-Specific Effects of cis-9,trans-11- and trans-10,cis-12-CLA on Immune Regulation in Ruminal Epithelial Cells. Animals 11:4, pages 1169.
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Wenqing Zhang, Kunpeng Zhang, Peng Zhang, Juanjuan Zheng, Congcong Min & Xiaoyu Li. (2021) Research Progress of Pancreas-Related Microorganisms and Pancreatic Cancer. Frontiers in Oncology 10.
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Ashenafi Bulle & Kian-Huat Lim. (2020) Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer. Signal Transduction and Targeted Therapy 5:1.
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Yali Song, Qiao Li, Shan Liao, Kangying Zhong, Yaxiong Jin & Tingting Zeng. (2020) Epstein-Barr virus-encoded miR-BART11 promotes tumor-associated macrophage-induced epithelial-mesenchymal transition via targeting FOXP1 in gastric cancer. Virology 548, pages 6-16.
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Lorenzo Castagnoli, Francesca De Santis, Tatiana Volpari, Claudio Vernieri, Elda Tagliabue, Massimo Di Nicola & Serenella M. Pupa. (2020) Cancer Stem Cells: Devil or Savior—Looking behind the Scenes of Immunotherapy Failure. Cells 9:3, pages 555.
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Chin-Jui Wu, Vignesh Sundararajan, Bor-Ching Sheu, Ruby Yun-Ju Huang & Lin-Hung Wei. (2019) Activation of STAT3 and STAT5 Signaling in Epithelial Ovarian Cancer Progression: Mechanism and Therapeutic Opportunity. Cancers 12:1, pages 24.
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José Esparza-López, Juan Francisco Alvarado-Muñoz, Elizabeth Escobar-Arriaga, Alfredo Ulloa-Aguirre & María de Jesús Ibarra-Sánchez. (2019) Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways. BMC Cancer 19:1.
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Anand Rajan, Katherine N. Gibson-Corley, Allen B. Choi, Georgina K. Ofori-Amanfo, Patrick Ten Eyck, Madelyn Espinosa-Cotton, Steven M. Sperry & Andrean L. Simons. (2019) Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas. Journal of Oncology 2019, pages 1-12.
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Mahin Khatami. (2018) Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism). Clinical and Translational Medicine 7:1.
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Li Wei, Haiyan Chang & Song Huo. (2018) Analyses on K‑ras mutations and fascin expression in patients with cardia cancer. Oncology Letters.
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Betül Ünlü & Henri H. Versteeg. (2018) Cancer‐associated thrombosis: The search for the holy grail continues. Research and Practice in Thrombosis and Haemostasis 2:4, pages 622-629.
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Elena Voronov, Charles A. Dinarello & Ron N. Apte. (2018) Interleukin-1α as an intracellular alarmin in cancer biology. Seminars in Immunology 38, pages 3-14.
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Gan Zhao, Chao Yang, Jing Yang, Pei Liu, Kangfeng Jiang, Aftab Shaukat, Haichong Wu & Ganzhen Deng. (2018) Placental exosome-mediated Bta-miR-499-Lin28B/let-7 axis regulates inflammatory bias during early pregnancy. Cell Death & Disease 9:6.
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Andrew Cannon, Christopher Thompson, Bradley R. Hall, Maneesh Jain, Sushil Kumar & Surinder K. Batra. (2018) Desmoplasia in pancreatic ductal adenocarcinoma: insight into pathological function and therapeutic potential. Genes & Cancer 9:3-4, pages 78-86.
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