3,561
Views
73
CrossRef citations to date
0
Altmetric
Original Research

Blocking the CD47-SIRPα axis by delivery of anti-CD47 antibody induces antitumor effects in glioma and glioma stem cells

, , , , , , , , , , , & show all
Article: e1391973 | Received 15 Aug 2017, Accepted 09 Oct 2017, Published online: 06 Nov 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Quansheng Lu, Xi Chen, Shan Wang, Yu Lu, Chunsheng Yang & Guan Jiang. (2020) Potential New Cancer Immunotherapy: Anti-CD47-SIRPα Antibodies. OncoTargets and Therapy 13, pages 9323-9331.
Read now
Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg. (2020) Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology. OncoImmunology 9:1.
Read now

Articles from other publishers (71)

Siji Chen, Shenghua Zhan, Sisi Ding, Qiange Zhang, Hanqin Xuan, Xueguang Zhang & Lei Cao. (2023) B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy. Journal of Cancer Research and Clinical Oncology 149:18, pages 16609-16621.
Crossref
Fuming Liang, Qing You, Xiaopeng Ma, Huayi Wang, Chen Wang, Zhaohui He, Yanlian Yang & Ling Zhu. (2023) Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy. Nano Research.
Crossref
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu & Patrick Ming-Kuen Tang. (2023) Tumour-associated macrophages: versatile players in the tumour microenvironment. Frontiers in Cell and Developmental Biology 11.
Crossref
Yu'e Liu, Linjun Weng, Yanjin Wang, Jin Zhang, Qi Wu, Pengcheng Zhao, Yufeng Shi, Ping Wang & Lan Fang. (2023) Deciphering the role of CD47 in cancer immunotherapy. Journal of Advanced Research.
Crossref
Lingyun Zhang, Yu Jiang, Gao Zhang & Shiyou Wei. (2023) The diversity and dynamics of tumor-associated macrophages in recurrent glioblastoma. Frontiers in Immunology 14.
Crossref
Shuyun Lin, Kaishu Li & Ling Qi. (2023) Cancer stem cells in brain tumors: From origin to clinical implications. MedComm 4:4.
Crossref
Frank Eckerdt & Leonidas C. Platanias. (2023) Emerging Role of Glioma Stem Cells in Mechanisms of Therapy Resistance. Cancers 15:13, pages 3458.
Crossref
Wenxi Xia, Neetu Singh, Shreya Goel & Sixiang Shi. (2023) Molecular imaging of innate immunity and immunotherapy. Advanced Drug Delivery Reviews 198, pages 114865.
Crossref
Julia S. Gillette, Elaina J. Wang, Richard S. Dowd & Steven A. Toms. (2023) Barriers to overcoming immunotherapy resistance in glioblastoma. Frontiers in Medicine 10.
Crossref
Xiangling Zhu, Yilong Fang, Yizhao Chen, Yu Chen, Wenming Hong, Wei Wei & Jiajie Tu. (2023) Interaction of tumor-associated microglia/macrophages and cancer stem cells in glioma. Life Sciences 320, pages 121558.
Crossref
Chen Feng, Rongzhang Chen, Weiwei Fang, Xinran Gao, Hanjie Ying, Xiao Zheng, Lujun Chen & Jingting Jiang. (2023) Synergistic effect of CD47 blockade in combination with cordycepin treatment against cancer. Frontiers in Pharmacology 14.
Crossref
Minjeong Kim, Kwang-Woo Jo, Hyojin Kim, Myoung-Eun Han & Sae-Ock Oh. (2022) Genetic heterogeneity of liver cancer stem cells. Anatomy & Cell Biology 56:1, pages 94-108.
Crossref
Nadezhda Knauer, Mariya Meschaninova, Sajjad Muhammad, Daniel Hänggi, Jean-Pierre Majoral, Ulf Dietrich Kahlert, Vladimir Kozlov & Evgeny K. Apartsin. (2023) Effects of Dendrimer-microRNA Nanoformulations against Glioblastoma Stem Cells. Pharmaceutics 15:3, pages 968.
Crossref
Yu’e Liu, Yanjin Wang, Yanrong Yang, Linjun Weng, Qi Wu, Jin Zhang, Pengcheng Zhao, Lan Fang, Yufeng Shi & Ping Wang. (2023) Emerging phagocytosis checkpoints in cancer immunotherapy. Signal Transduction and Targeted Therapy 8:1.
Crossref
Anita L. Kalluri, Pavan P. Shah & Michael Lim. (2023) The Tumor Immune Microenvironment in Primary CNS Neoplasms: A Review of Current Knowledge and Therapeutic Approaches. International Journal of Molecular Sciences 24:3, pages 2020.
Crossref
Zhi-Guo Lu, Jie Shen, Jun Yang, Jing-Wen Wang, Rui-Chen Zhao, Tian-Lu Zhang, Jing Guo & Xin Zhang. (2023) Nucleic acid drug vectors for diagnosis and treatment of brain diseases. Signal Transduction and Targeted Therapy 8:1.
Crossref
Angelique Sao-Mai S. Tay, Keith L. Black & John S. Yu. 2023. Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1. Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1 51 72 .
Yuqi Zheng & Manuel B. Graeber. (2022) Microglia and Brain Macrophages as Drivers of Glioma Progression. International Journal of Molecular Sciences 23:24, pages 15612.
Crossref
Xuehua Zhang, Leilei Zhao, He Zhang, Yurui Zhang, Huanyu Ju, Xiaoyu Wang, Huan Ren, Xiao Zhu & Yucui Dong. (2022) The immunosuppressive microenvironment and immunotherapy in human glioblastoma. Frontiers in Immunology 13.
Crossref
Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai & Xiaodan Jiang. (2022) The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3. Journal of Immunology Research 2022, pages 1-19.
Crossref
Feng Tang, Zhiyong Pan, Yi Wang, Tian Lan, Mengyue Wang, Fengping Li, Wei Quan, Zhenyuan Liu, Zefen Wang & Zhiqiang Li. (2022) Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma. Neuroscience Bulletin 38:9, pages 1069-1084.
Crossref
Yuan Pan & Michelle Monje. (2022) Neuron–Glial Interactions in Health and Brain Cancer. Advanced Biology 6:9.
Crossref
Mohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah, Navid Pourzardosht & Vahideh Tarhriz. (2022) Exosome-based strategies for diagnosis and therapy of glioma cancer. Cancer Cell International 22:1.
Crossref
Mengwan Wu, Ying Shi, Luyi Zhu, Luoyi Chen, Xinchen Zhao & Chuan Xu. (2022) Macrophages in Glioblastoma Development and Therapy: A Double-Edged Sword. Life 12:8, pages 1225.
Crossref
Luohong Li, Jing Zhou, Xueting Dong, Qianjin Liao, Dongbo Zhou & Yanhong Zhou. (2022) Dendritic cell vaccines for glioblastoma fail to complete clinical translation: Bottlenecks and potential countermeasures. International Immunopharmacology 109, pages 108929.
Crossref
Guoqing Wang, Kunhong Zhong, Zeng Wang, Zongliang Zhang, Xin Tang, Aiping Tong & Liangxue Zhou. (2022) Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities. Frontiers in Immunology 13.
Crossref
Leonie M. Behrens, Timo K. van den Berg & Marjolein van Egmond. (2022) Targeting the CD47-SIRPα Innate Immune Checkpoint to Potentiate Antibody Therapy in Cancer by Neutrophils. Cancers 14:14, pages 3366.
Crossref
Abdullahi Alausa, Khadijat Ayodeji Lawal, Oluwakemi Arinola Babatunde, E.N.O. Obiwulu, Olajumoke Christianah Oladokun, Olumide Samuel Fadahunsi, Ugwu Obiora Celestine, Emmanuel Ugbede Moses, Ifunanya Rejoice Akaniro & Peter Ifeoluwa Adegbola. (2022) Overcoming immunotherapeutic resistance in PDAC: SIRPα-CD47 blockade. Pharmacological Research 181, pages 106264.
Crossref
Enrico Conte. (2022) Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches. Pharmacology & Therapeutics 234, pages 108031.
Crossref
Julie Mazzolini, Sigrid Le Clerc, Gregoire Morisse, Cédric Coulonges, Jean‐François Zagury & Dirk Sieger. (2022) Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages. Glia 70:6, pages 1027-1051.
Crossref
Nadezhda Knauer, Valeria Arkhipova, Guanzhang Li, Michael Hewera, Ekaterina Pashkina, Phuong-Hien Nguyen, Maria Meschaninova, Vladimir Kozlov, Wei Zhang, Roland Croner, Anne-Marie Caminade, Jean-Pierre Majoral, Evgeny Apartsin & Ulf Kahlert. (2022) In Vitro Validation of the Therapeutic Potential of Dendrimer-Based Nanoformulations against Tumor Stem Cells. International Journal of Molecular Sciences 23:10, pages 5691.
Crossref
Johannes K. Andersen, Hrvoje Miletic & Jubayer A. Hossain. (2022) Tumor-Associated Macrophages in Gliomas—Basic Insights and Treatment Opportunities. Cancers 14:5, pages 1319.
Crossref
Jiejian Chen, Qi Dai, QiYao Yang, Xiaoyan Bao, Yi Zhou, Haiqing Zhong, Linjie Wu, Tiantian Wang, Zhicheng Zhang, Yiying Lu, Zhentao Zhang, Mengting Lin, Min Han & Qichun Wei. (2022) Therapeutic nucleus-access BNCT drug combined CD47-targeting gene editing in glioblastoma. Journal of Nanobiotechnology 20:1.
Crossref
Keyang Yang, Zhijing Wu, Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xun Zhang, Liyang Zhang, Yun Peng, Weijie Ye, Wenjing Zeng, Zhixiong Liu & Quan Cheng. (2022) Glioma targeted therapy: insight into future of molecular approaches. Molecular Cancer 21:1.
Crossref
Thomas Kuntzel & Dominique Bagnard. (2022) Manipulating Macrophage/Microglia Polarization to Treat Glioblastoma or Multiple Sclerosis. Pharmaceutics 14:2, pages 344.
Crossref
Susan Moradinasab, Atieh Pourbagheri-Sigaroodi, Seyed H. Ghaffari & Davood Bashash. (2022) Targeting macrophage-mediated tumor cell phagocytosis: An overview of phagocytosis checkpoints blockade, nanomedicine intervention, and engineered CAR-macrophage therapy. International Immunopharmacology 103, pages 108499.
Crossref
Amir Nazem, Samantha C. Guiry, Mehrdad Pourfathi, Jeffrey B. Ware, Hannah Anderson, Srikant Kamesh Iyer, Brianna F. Moon, Yi Fan, Walter R. Witschey, Rahim Rizi, Stephen J. Bagley, Arati Desai, Donald M. O’Rourke, Steven Brem, MacLean Nasrallah & Ali Nabavizadeh. (2022) MR susceptibility imaging for detection of tumor-associated macrophages in glioblastoma. Journal of Neuro-Oncology 156:3, pages 645-653.
Crossref
Valery V. Veselov, Alexander E. Nosyrev, László Jicsinszky, Renad N. Alyautdin & Giancarlo Cravotto. (2022) Targeted Delivery Methods for Anticancer Drugs. Cancers 14:3, pages 622.
Crossref
Cristiana Tanase, Ana Maria Enciu, Elena Codrici, Ionela Daniela Popescu, Maria Dudau, Ana Maria Dobri, Sevinci Pop, Simona Mihai, Ancuța-Augustina Gheorghișan-Gălățeanu & Mihail Eugen Hinescu. (2022) Fatty Acids, CD36, Thrombospondin-1, and CD47 in Glioblastoma: Together and/or Separately?. International Journal of Molecular Sciences 23:2, pages 604.
Crossref
Elaina J. Wang, Jia-Shu Chen, Saket Jain, Ramin A. Morshed, Alexander F. Haddad, Sabraj Gill, Angad S. Beniwal & Manish K. Aghi. (2021) Immunotherapy Resistance in Glioblastoma. Frontiers in Genetics 12.
Crossref
Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Daliya Kancheva, Isabelle Scheyltjens, Jo A. Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi & Geert Raes. (2021) Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha. Frontiers in Immunology 12.
Crossref
Hao Wu, Jialin Liu, Zhifei Wang, Wen Yuan & Ling Chen. (2021) Prospects of antibodies targeting CD47 or CD24 in the treatment of glioblastoma. CNS Neuroscience & Therapeutics 27:10, pages 1105-1117.
Crossref
Evan D. Bander, Maricruz Rivera & Babacar Cisse. (2021) The Benedict Arnold of the Central Nervous System Tumor Microenvironment? The Role of Microglia/Macrophages in Glioma. World Neurosurgery 154, pages 214-221.
Crossref
Jie Song, Han Zhang, Dongli Wang, Jing Wang, Jianfen Zhou, Zhiyi Zhang, Jun Wang, Yang Hu, Qianzhu Xu, Cao Xie, Weiyue Lu & Min Liu. (2021) Hydrogel loading functionalized PAMAM/shRNA complex for postsurgical glioblastoma treatment. Journal of Controlled Release 338, pages 583-592.
Crossref
Chirayu R. Chokshi, Benjamin A. Brakel, Nazanin Tatari, Neil Savage, Sabra K. Salim, Chitra Venugopal & Sheila K. Singh. (2021) Advances in Immunotherapy for Adult Glioblastoma. Cancers 13:14, pages 3400.
Crossref
Vassilis Genoud & Denis Migliorini. (2021) Challenging Hurdles of Current Targeting in Glioblastoma: A Focus on Immunotherapeutic Strategies. International Journal of Molecular Sciences 22:7, pages 3493.
Crossref
Li Zhang, Buyi Zhang, Zhangqi Dou, Jiawei Wu, Yasaman Iranmanesh, Biao Jiang, Chongran Sun & Jianmin Zhang. (2021) Immune Checkpoint-Associated Locations of Diffuse Gliomas Comparing Pediatric With Adult Patients Based on Voxel-Wise Analysis. Frontiers in Immunology 12.
Crossref
Pedro Reimunde, Alba Pensado-López, Martín Carreira Crende, Vanesa Lombao Iglesias, Laura Sánchez, Marta Torrecilla-Parra, Cristina M. Ramírez, Clément Anfray & Fernando Torres Andón. (2021) Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments. Cancers 13:5, pages 1087.
Crossref
Natasha D. Sheybani, Victoria R. Breza, Soumen Paul, Katelyenn S. McCauley, Stuart S. Berr, G. Wilson Miller, Kiel D. Neumann & Richard J. Price. (2021) ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. Journal of Controlled Release 331, pages 19-29.
Crossref
Keenan Piper, Lisa DePledge, Michael Karsy & Charles Cobbs. (2021) Glioma Stem Cells as Immunotherapeutic Targets: Advancements and Challenges. Frontiers in Oncology 11.
Crossref
嘉欣 李. (2021) Application of CD47 Inhibitor in Tumor Therapy. Pharmacy Information 10:03, pages 129-137.
Crossref
Jiaying Yang, Yongjun Yao, Li Tong, Ziwei Zhu, Lei Wang & Jinju Yang. (2021) CD47 is highly expressed in gliomas and targeting CD47 is a promising therapeutic strategy. European Journal of Inflammation 19, pages 205873922110008.
Crossref
Nan Cheng, Xuexia Bai, Yuxin Shu, Owais Ahmad & Pingping Shen. (2021) Targeting tumor-associated macrophages as an antitumor strategy. Biochemical Pharmacology 183, pages 114354.
Crossref
Xuefei Zhou, Xiangrui Liu & Leaf Huang. (2020) Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention. Advanced Functional Materials 31:5, pages 2006220.
Crossref
Yichen Peng, Feng Chen, Shenglan Li, Xiu Liu, Can Wang, Chunna Yu & Wenbin Li. (2021) Tumor‐associated macrophages as treatment targets in glioma. Brain Science Advances 6:4, pages 306-323.
Crossref
Jinyang Hu, Qungen Xiao, Minhai Dong, Dongsheng Guo, Xudong Wu & Baofeng Wang. (2020) Glioblastoma Immunotherapy Targeting the Innate Immune Checkpoint CD47-SIRPα Axis. Frontiers in Immunology 11.
Crossref
Minfeng Yang, In Young Oh, Arpan Mahanty, Wei-Lin Jin & Jung Sun Yoo. (2020) Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives. Cancers 12:9, pages 2334.
Crossref
Sukhbir Kaur, Kyle V Cicalese, Rajdeep Banerjee & David D Roberts. (2020) Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment. Antibody Therapeutics 3:3, pages 179-192.
Crossref
Jing Zhang, Su-Bee Tan & Zhi-Gang Guo. (2020) CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes. World Journal of Diabetes 11:6, pages 239-251.
Crossref
Hélène Grégoire, Loris Roncali, Audrey Rousseau, Michel Chérel, Yves Delneste, Pascale Jeannin, François Hindré & Emmanuel Garcion. (2020) Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma. Frontiers in Pharmacology 11.
Crossref
Meng Cheng, Zheng Wei Zhang, Xing Hu Ji, Yadi Xu, Erbao Bian & Bing Zhao. (2020) Super-enhancers: A new frontier for glioma treatment. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1873:2, pages 188353.
Crossref
Yunteng Zhao, Xiaoxiao Yu, Haocheng Tang, Ri Han, Xianwen Wang, Jianqi Wang, Ke Wang & Gang Li. (2020) MicroRNA-200a Promotes Phagocytosis of Macrophages and Suppresses Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma by Targeting CD47. BioMed Research International 2020, pages 1-13.
Crossref
Wenting Zhang, Qinghua Huang, Weiwei Xiao, Yue Zhao, Jiang Pi, Huan Xu, Hongxia Zhao, Junfa Xu, Colin E. Evans & Hua Jin. (2020) Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα Axis. Frontiers in Immunology 11.
Crossref
Myriam Catalano, Giuseppina D’Alessandro, Flavia Trettel & Cristina Limatola. 2020. Glioma Signaling. Glioma Signaling 281 298 .
Elena Martin-Orozco, Ana Sanchez-Fernandez, Irene Ortiz-Parra & Maria Ayala-San Nicolas. (2019) WNT Signaling in Tumors: The Way to Evade Drugs and Immunity. Frontiers in Immunology 10.
Crossref
David H. Gutmann & Helmut Kettenmann. (2019) Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology. Neuron 104:3, pages 442-449.
Crossref
Suchismita Mohanty, Maryam Aghighi, Ketan Yerneni, Johanna Lena Theruvath & Heike E. Daldrup‐Link. (2019) Improving the efficacy of osteosarcoma therapy: combining drugs that turn cancer cell ‘don't eat me’ signals off and ‘eat me’ signals on. Molecular Oncology 13:10, pages 2049-2061.
Crossref
Qin Zhao, Jinyang Wang, Chengcheng Yin, Peng Zhang, Jinglun Zhang, Miusi Shi, Kailun Shen, Yin Xiao, Yanbing Zhao, Xiangliang Yang & Yufeng Zhang. (2019) Near-Infrared Light-Sensitive Nano Neuro-Immune Blocker Capsule Relieves Pain and Enhances the Innate Immune Response for Necrotizing Infection. Nano Letters 19:9, pages 5904-5914.
Crossref
Martina Vaskova, Michal Tichy, Josef Zamecnik, Petr Liby, Daniela Kuzilkova, Ales Vicha, Jan Hrabeta, Tomas Kalina, Jan Stary & Ondrej Hrusak. (2019) Cytometric analysis of cell suspension generated by cavitron ultrasonic surgical aspirator in pediatric brain tumors. Journal of Neuro-Oncology 143:1, pages 15-25.
Crossref
Gregor HutterJohanna TheruvathClaus Moritz GraefMichael Zhang, Matthew Kenneth SchoenEva Maria ManzMariko L. Bennett, Andrew OlsonTej D. AzadRahul SinhaCarmel ChanSuzana Assad KahnSharareh GholaminChristy WilsonGerald GrantJoy HeIrving L. WeissmanSiddhartha S. Mitra & Samuel H. Cheshier. (2019) Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma. Proceedings of the National Academy of Sciences 116:3, pages 997-1006.
Crossref
Kai Zhou, Yue-Liang Yao, Zhi-Cheng He, Cong Chen, Xiao-Ning Zhang, Kai-Di Yang, Yu-Qi Liu, Qing Liu, Wen-Juan Fu, Ya-Ping Chen, Qin Niu, Qing-Hua Ma, Rong Zhou, Xiao-Hong Yao, Xia Zhang, You-Hong Cui, Xiu-Wu Bian, Yu Shi & Yi-Fang Ping. (2018) VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells. Cell Death & Disease 9:10.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.