Advanced search
Publication Cover
OncoImmunology Volume 7, 2018 - Issue 2
Submit an article Journal homepage
2,219
Views
48
CrossRef citations to date
0
Altmetric
Original Research

Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype

Simone BorgoniDept. of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, Torino, Italy;Center for Experimental Research and Medical Studies, University Hospital Città della Salute e della Scienza di Torino, via Santena 5, Torino, Italy
,
Andrea IannelloCenter for Molecular Systems Biology, University of Turin, Orbassano, Turin, Italy;Dept. of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, ItalyORCID Iconhttps://orcid.org/0000-0001-8940-1406
ORCID Icon,
Santina CutrupiCenter for Molecular Systems Biology, University of Turin, Orbassano, Turin, Italy;Dept. of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
,
Paola AllavenaDept. Immunology and Inflammation, IRCCS-Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano (Milano), Italy
,
Maurizio D'IncalciDept. of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
,
Francesco NovelliDept. of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, Torino, Italy;Center for Experimental Research and Medical Studies, University Hospital Città della Salute e della Scienza di Torino, via Santena 5, Torino, Italy;Transplant Immunology Service, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy;Molecular Biotechnology Center, via Nizza 52, Torino, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6259-5666
ORCID Icon &
Paola CappelloDept. of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, Torino, Italy;Center for Experimental Research and Medical Studies, University Hospital Città della Salute e della Scienza di Torino, via Santena 5, Torino, Italy;Molecular Biotechnology Center, via Nizza 52, Torino, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5321-7794
ORCID Icon show all
Article: e1393596 | Received 09 Jun 2017, Accepted 13 Oct 2017, Published online: 13 Nov 2017

Citations (48)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Sarah Tettamanti, Maria Caterina Rotiroti, Greta Maria Paola Giordano Attianese, Silvia Arcangeli, Ronghua Zhang, Priyanka Banerjee, Giovanni Galletti, Sheighlah McManus, Massimiliano Mazza, Fabio Nicolini, Giovanni Martinelli, Cristina Ivan, Tania Veliz Rodriguez, Federica Barbaglio, Lydia Scarfò, Maurilio Ponzoni, William Wierda, Varsha Gandhi, Michael Keating, Andrea Biondi, Federico Caligaris-Cappio, Ettore Biagi, Paolo Ghia & Maria Teresa Sabrina Bertilaccio. (2022) Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia. Leukemia & Lymphoma 63:7, pages 1566-1579.
Read now
Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg. (2020) Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology. OncoImmunology 9:1.
Read now

Articles from other publishers (46)

Lea Falkowski, Joerg Buddenkotte & Angeliki Datsi. (2024) Epigenetics in T-cell driven inflammation and cancer. Seminars in Cell & Developmental Biology 154, pages 250-260.
Crossref
Yue Shen, Jia-Xi Chen, Ming Li, Ze Xiang, Jian Wu & Yi-Jin Wang. (2023) Role of tumor-associated macrophages in common digestive system malignant tumors. World Journal of Gastrointestinal Oncology 15:4, pages 596-616.
Crossref
Maria Alvanou, Memnon Lysandrou, Panayota Christophi, Nikoleta Psatha, Alexandros Spyridonidis, Anastasia Papadopoulou & Evangelia Yannaki. (2023) Empowering the Potential of CAR-T Cell Immunotherapies by Epigenetic Reprogramming. Cancers 15:7, pages 1935.
Crossref
Alok K. Mishra, Shahid Banday, Ravi Bharadwaj, Amjad Ali, Romana Rashid, Ankur Kulshreshtha & Sunil K. Malonia. (2022) Macrophages as a Potential Immunotherapeutic Target in Solid Cancers. Vaccines 11:1, pages 55.
Crossref
Enrico Conte. (2022) Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches. Pharmacology & Therapeutics 234, pages 108031.
Crossref
Hélène Kaplon. (2022) Translational Learnings in the Development of Chemo-Immunotherapy Combination to Bypass the Cold Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 12.
Crossref
Paola Allavena, Cristina Belgiovine, Elisabeth Digifico, Roberta Frapolli & Maurizio D’Incalci. (2022) Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on Immune Cells of the Tumor Microenvironment. Frontiers in Oncology 12.
Crossref
Shuhang Wang, Yuqi Yang, Peiwen Ma, Huiyao Huang, Qiyu Tang, Huilei Miao, Yuan Fang, Ning Jiang, Yandong Li, Qi Zhu, Wei Tao, Yan Zha & Ning Li. (2022) Landscape and perspectives of macrophage -targeted cancer therapy in clinical trials. Molecular Therapy - Oncolytics 24, pages 799-813.
Crossref
Takashi MaruYama, WanJun Chen & Hiroyuki Shibata. (2022) TGF-β and Cancer Immunotherapy. Biological and Pharmaceutical Bulletin 45:2, pages 155-161.
Crossref
Marcus T. T. Roalsø, Øyvind H. Hald, Marina Alexeeva & Kjetil Søreide. (2022) Emerging Role of Epigenetic Alterations as Biomarkers and Novel Targets for Treatments in Pancreatic Ductal Adenocarcinoma. Cancers 14:3, pages 546.
Crossref
Xiaoling Ding, Xinchen Sun, Huihui Cai, Lei Wu, Ying Liu, Yu Zhao, Dingjingyu Zhou, Guiping Yu & Xiaorong Zhou. (2022) Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy. Frontiers in Oncology 11.
Crossref
Izabela Szulc-Kielbik & Michal Kielbik. 2022. Interaction of Immune and Cancer Cells. Interaction of Immune and Cancer Cells 107 140 .
Yubin Li, Xuyao Zhang, Xian Zeng, Shaofei Wang & Hongbin Wang. 2022. Macrophage Targeted Delivery Systems. Macrophage Targeted Delivery Systems 279 315 .
Enyong Dai, Zhi Zhu, Shudipto Wahed, Zhaoxia Qu, Walter J. Storkus & Zong Sheng Guo. (2021) Epigenetic modulation of antitumor immunity for improved cancer immunotherapy. Molecular Cancer 20:1.
Crossref
Cristina Belgiovine, Roberta Frapolli, Manuela Liguori, Elisabeth Digifico, Federico Simone Colombo, Marina Meroni, Paola Allavena & Maurizio D'Incalci. (2021) Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy. European Journal of Immunology 51:11, pages 2677-2686.
Crossref
Patrick Michl, Matthias Löhr, John P. Neoptolemos, Gabriele Capurso, Vinciane Rebours, Nuria Malats, Mathilde Ollivier & Luigi Ricciardiello. (2021) UEG position paper on pancreatic cancer. Bringing pancreatic cancer to the 21st century: Prevent, detect, and treat the disease earlier and better. United European Gastroenterology Journal 9:7, pages 860-871.
Crossref
Elodie Renaude, Marie Kroemer, Christophe Borg, Paul Peixoto, Eric Hervouet, Romain Loyon & Olivier Adotévi. (2021) Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy. Frontiers in Immunology 12.
Crossref
Ramiz S. Ahmad, Timothy D. Eubank, Slawomir Lukomski & Brian A. Boone. (2021) Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer. Biomolecules 11:6, pages 901.
Crossref
Ashleigh R. Poh & Matthias Ernst. (2021) Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Therapeutic Opportunities and Clinical Challenges. Cancers 13:12, pages 2860.
Crossref
Aaron T. Ciner, Keaton Jones, Ruth J. Muschel & Pnina Brodt. (2021) The unique immune microenvironment of liver metastases: Challenges and opportunities. Seminars in Cancer Biology 71, pages 143-156.
Crossref
Aydar Khabipov, Eric Freund, Kim Rouven Liedtke, Andre Käding, Janik Riese, Julia van der Linde, Stephan Kersting, Lars-Ivo Partecke & Sander Bekeschus. (2021) Murine Macrophages Modulate Their Inflammatory Profile in Response to Gas Plasma-Inactivated Pancreatic Cancer Cells. Cancers 13:11, pages 2525.
Crossref
Tiffany Davia Ricketts, Nestor Prieto-Dominguez, Pramod Sreerama Gowda & Eric Ubil. (2021) Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes. Frontiers in Immunology 12.
Crossref
Cecilia Roux, Gianluca Mucciolo, Joanna Kopecka, Francesco Novelli, Chiara Riganti & Paola Cappello. (2021) IL17A Depletion Affects the Metabolism of Macrophages Treated with Gemcitabine. Antioxidants 10:3, pages 422.
Crossref
Alberto Mantovani, Federica Marchesi, Sebastien Jaillon, Cecilia Garlanda & Paola Allavena. (2021) Tumor-associated myeloid cells: diversity and therapeutic targeting. Cellular & Molecular Immunology 18:3, pages 566-578.
Crossref
Gianluca Mucciolo, Claudia CurcioCecilia Roux, Wanda Y. LiMichela CapelloRoberta CurtoRoberto ChiarleDaniele GiordanoMaria Antonietta Satolli, Rita LawlorAldo Scarpa, Pavol Lukac, Dmitry StakheevPaolo ProveroLuca Vannucci, Tak W. Mak, Francesco Novelli & Paola Cappello. (2021) IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions. Proceedings of the National Academy of Sciences 118:6.
Crossref
Sen Yang, Qiaofei Liu & Quan Liao. (2021) Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming. Frontiers in Cell and Developmental Biology 8.
Crossref
Nan Cheng, Xuexia Bai, Yuxin Shu, Owais Ahmad & Pingping Shen. (2021) Targeting tumor-associated macrophages as an antitumor strategy. Biochemical Pharmacology 183, pages 114354.
Crossref
Erin Morales, Michael Olson, Fiorella Iglesias, Saurabh Dahiya, Tim Luetkens & Djordje Atanackovic. (2020) Role of immunotherapy in Ewing sarcoma. Journal for ImmunoTherapy of Cancer 8:2, pages e000653.
Crossref
Adrián Povo-Retana, Marina Mojena, Adrian B. Stremtan, Victoria B. Fernández-García, Ana Gómez-Sáez, Cristina Nuevo-Tapioles, José M. Molina-Guijarro, José Avendaño-Ortiz, José M. Cuezva, Eduardo López-Collazo, Juan F. Martínez-Leal & Lisardo Boscá. (2020) Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate—Novel Insights. Cancers 12:10, pages 3060.
Crossref
Elaheh Nasrollahzadeh, Sepideh Razi, Mahsa Keshavarz-Fathi, Massimiliano Mazzone & Nima Rezaei. (2020) Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site. Cancer Immunology, Immunotherapy 69:9, pages 1673-1697.
Crossref
Łukasz Zadka, Damian J. Grybowski & Piotr Dzięgiel. (2020) Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance. Cellular Oncology 43:4, pages 539-575.
Crossref
Camille Huart, Jia-Wei Chen, Benjamin Le Calvé, Carine Michiels & Anne-Catherine Wéra. (2020) Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?. International Journal of Molecular Sciences 21:13, pages 4767.
Crossref
Sean H. Colligan, Stephanie L. Tzetzo & Scott I. Abrams. (2020) Myeloid-driven mechanisms as barriers to antitumor CD8+ T cell activity. Molecular Immunology 118, pages 165-173.
Crossref
Paola Allavena, Manuela Liguori & Cristina Belgiovine. 2020. Approaching Complex Diseases. Approaching Complex Diseases 287 300 .
Anfray, Ummarino, Andón & Allavena. (2019) Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses. Cells 9:1, pages 46.
Crossref
Priyanka Banerjee, Ronghua Zhang, Cristina Ivan, Giovanni Galletti, Karen Clise-Dwyer, Federica Barbaglio, Lydia Scarfò, Miguel Aracil, Christian Klein, William Wierda, William Plunkett, Federico Caligaris-Cappio, Varsha Gandhi, Michael J. Keating & Maria Teresa S. Bertilaccio. (2019) Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia. Cancer Immunology Research 7:12, pages 2036-2051.
Crossref
Tanja Jakoš, Anja Pišlar, Anahid Jewett & Janko Kos. (2019) Cysteine Cathepsins in Tumor-Associated Immune Cells. Frontiers in Immunology 10.
Crossref
Xinlong Zang, Xiaoxu Zhang, Haiyang Hu, Mingxi Qiao, Xiuli Zhao, Yihui Deng & Dawei Chen. (2019) Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy. Molecular Pharmaceutics 16:5, pages 2249-2258.
Crossref
Laura Carminati, Denise Pinessi, Patrizia Borsotti, Lucia Minoli, Raffaella Giavazzi, Maurizio D’Incalci, Dorina Belotti & Giulia Taraboletti. (2019) Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma. Carcinogenesis 40:2, pages 303-312.
Crossref
Lei Cai, Theodoros Michelakos, Vikram Deshpande, Kshitij S. Arora, Teppei Yamada, David T. Ting, Marty S. Taylor, Carlos Fernandez-del Castillo, Andrew L. Warshaw, Keith D. Lillemoe, Soldano Ferrone & Cristina R. Ferrone. (2019) Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs). Clinical Cancer Research 25:8, pages 2644-2655.
Crossref
Jing Liu, Wenna Jiang, Kaili Zhao, Hongwei Wang, Tianxing Zhou, Weiwei Bai, Xiuchao Wang, Tiansuo Zhao, Chongbiao Huang, Song Gao, Tai Qin, Wenwen Yu, Bo Yang, Xin Li, Danqi Fu, Wei Tan, Shengyu Yang, He Ren & Jihui Hao. (2019) Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma. Journal of Experimental Medicine 216:3, pages 656-673.
Crossref
Andrea Iannello, Simona Rolla, Alessandro Maglione, Giulio Ferrero, Valentina Bardina, Ilenia Inaudi, Stefania De Mercanti, Francesco Novelli, Lucrezia D'Antuono, Simona Cardaropoli, Tullia Todros, Maria Vittoria Turrini, Cinzia Cordioli, Giorgia Puorro, Angela Marsili, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Cordero, Michele De Bortoli, Luca Durelli, Andrea Visconti, Santina Cutrupi & Marinella Clerico. (2019) Pregnancy Epigenetic Signature in T Helper 17 and T Regulatory Cells in Multiple Sclerosis. Frontiers in Immunology 9.
Crossref
Nicholas L. Denton, Chun-Yu Chen, Brian Hutzen, Mark A. Currier, Thomas Scott, Brooke Nartker, Jennifer L. Leddon, Pin-Yi Wang, Rachelle Srinivas, Kevin A. Cassady, William F. Goins & Timothy P. Cripe. (2018) Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment. Molecular Therapy - Oncolytics 11, pages 62-74.
Crossref
Emile J. Clappaert, Aleksandar Murgaski, Helena Van Damme, Mate Kiss & Damya Laoui. (2018) Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy. Frontiers in Immunology 9.
Crossref
Paola Cappello, Claudia Curcio, Giorgia Mandili, Cecilia Roux, Sara Bulfamante & Francesco Novelli. (2018) Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners. Cancers 10:2, pages 51.
Crossref
Souptik Barua, Luisa Solis, Edwin Roger Parra, Naohiro Uraoka, Mei Jiang, Huamin Wang, Jaime Rodriguez-Canales, Ignacio Wistuba, Anirban Maitra, Subrata Sen & Arvind Rao. (2018) A Functional Spatial Analysis Platform for Discovery of Immunological Interactions Predictive of Low-Grade to High-Grade Transition of Pancreatic Intraductal Papillary Mucinous Neoplasms. Cancer Informatics 17, pages 117693511878288.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.