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Original Research

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

, , , , ORCID Icon, , , & , MD show all
Article: e1404216 | Received 22 Sep 2017, Accepted 06 Nov 2017, Published online: 07 May 2018

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Read on this site (2)

Melania Scarpa, Chiara Marchiori, Marco Scarpa & Ignazio Castagliuolo. (2021) CD80 expression is upregulated by TP53 activation in human cancer epithelial cells. OncoImmunology 10:1.
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Sang-Soo Kim, Joe B. Harford, Manish Moghe, Antonina Rait & Esther H. Chang. (2018) Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor. OncoImmunology 7:10.
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Articles from other publishers (19)

Joe B. Harford. (2023) A Second Career for p53 as A Broad-Spectrum Antiviral?. Viruses 15:12, pages 2377.
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Xuanyu Zhang, Chao Shang, Xue Qiao & Yan Guo. (2023) Role and clinical significance of immunogenic cell death biomarkers in chemoresistance and immunoregulation of head and neck squamous cell carcinoma. Biomedicine & Pharmacotherapy 167, pages 115509.
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Vanessa Klapp, Beatriz Álvarez-Abril, Giuseppe Leuzzi, Guido Kroemer, Alberto Ciccia & Lorenzo Galluzzi. (2023) The DNA Damage Response and Inflammation in Cancer. Cancer Discovery 13:7, pages 1521-1545.
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Xiaohui Pan, Wenxin Zhang, Hongjie Guo, Longsheng Wang, Honghai Wu, Ling Ding & Bo Yang. (2023) Strategies involving STING pathway activation for cancer immunotherapy: Mechanism and agonists. Biochemical Pharmacology 213, pages 115596.
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Vikash Kansal, Andre J Burnham, Brendan L C Kinney, Nabil F Saba, Chrystal Paulos, Gregory B Lesinski, Zachary S Buchwald & Nicole C Schmitt. (2023) Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models. Journal for ImmunoTherapy of Cancer 11:1, pages e005940.
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Sang-Soo Kim, Joe B. Harford, Manish Moghe, Caroline Doherty & Esther H. Chang. (2022) A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models. Cells 11:21, pages 3434.
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Michihisa Kono, Shin Saito, Ann Marie Egloff, Clint T. Allen & Ravindra Uppaluri. (2022) The mouse oral carcinoma (MOC) model: A 10-year retrospective on model development and head and neck cancer investigations. Oral Oncology 132, pages 106012.
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Joe B. Harford, Sang Soo Kim, Kathleen F. Pirollo & Esther H. Chang. (2022) TP53 Gene Therapy as a Potential Treatment for Patients with COVID-19. Viruses 14:4, pages 739.
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Hongpan Zhang, Zheng Huang, Yangguang Song, Zhihao Yang, Qi Shi, Kaige Wang, Zhiyu Zhang, Zheng Liu, Xiaobin Cui & Feng Li. (2021) The TP53-Related Signature Predicts Immune Cell Infiltration, Therapeutic Response, and Prognosis in Patients With Esophageal Carcinoma. Frontiers in Genetics 12.
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Laure-Anne Teuwen, Laura P.M.H. De Rooij, Anne Cuypers, Katerina Rohlenova, Sébastien J. Dumas, Melissa García-Caballero, Elda Meta, Jacob Amersfoort, Federico Taverna, Lisa M. Becker, Nuphar Veiga, Anna Rita Cantelmo, Vincent Geldhof, Nadine V. Conchinha, Joanna Kalucka, Lucas Treps, Lena-Christin Conradi, Shawez Khan, Tobias K. Karakach, Stefaan Soenen, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Steven Van Laere, Mieke Dewerchin, Luc Dirix, Massimiliano Mazzone, Yonglun Luo, Peter Vermeulen & Peter Carmeliet. (2021) Tumor vessel co-option probed by single-cell analysis. Cell Reports 35:11, pages 109253.
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Jitka Fucikova, Oliver Kepp, Lenka Kasikova, Giulia Petroni, Takahiro Yamazaki, Peng Liu, Liwei Zhao, Radek Spisek, Guido Kroemer & Lorenzo Galluzzi. (2020) Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death & Disease 11:11.
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Albert B. DeLeo & Ettore Appella. (2020) The p53 Saga: Early Steps in the Development of Tumor Immunotherapy. The Journal of Immunology 204:9, pages 2321-2328.
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Catarina Roma-Rodrigues, Lorenzo Rivas-García, Pedro V. Baptista & Alexandra R. Fernandes. (2020) Gene Therapy in Cancer Treatment: Why Go Nano?. Pharmaceutics 12:3, pages 233.
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Sang‐Soo Kim, Joe B. Harford, Manish Moghe, Tiffani Slaughter, Caroline Doherty & Esther H. Chang. (2019) A tumor‐targeting nanomedicine carrying the p53 gene crosses the blood–brain barrier and enhances anti‐PD‐1 immunotherapy in mouse models of glioblastoma. International Journal of Cancer 145:9, pages 2535-2546.
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Wei Li, Lin Xu, Jun Han, Kefei Yuan & Hong Wu. (2019) Identification and Validation of Tumor Stromal Immunotype in Patients With Hepatocellular Carcinoma. Frontiers in Oncology 9.
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Minori Okubo, Maiko Miyazaki, Eiji Yuba & Atsushi Harada. (2019) Chondroitin Sulfate-Based pH-Sensitive Polymer-Modified Liposomes for Intracellular Antigen Delivery and Induction of Cancer Immunity. Bioconjugate Chemistry 30:5, pages 1518-1529.
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Weimin Lin, Miao Chen, Le Hong, Hang Zhao & Qianming Chen. (2018) Crosstalk Between PD-1/PD-L1 Blockade and Its Combinatorial Therapies in Tumor Immune Microenvironment: A Focus on HNSCC. Frontiers in Oncology 8.
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