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OncoImmunology Volume 7, 2018 - Issue 7
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Original Research

Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells

Keunok JungPriority Research Center for Molecular Science & Technology, Ajou University, Suwon, Republic of KoreaORCID Iconhttp://orcid.org/0000-0003-2967-8432 http://orcid.org/0000-0003-2967-8432 http://orcid.org/0000-0003-2967-8432View further author information
ORCID Icon ORCID Icon ORCID Icon,
Ji-Hee HaDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of KoreaView further author information
,
Jung-Eun KimDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of KoreaView further author information
,
Jeong-Ah KimDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of KoreaView further author information
,
Ye-Jin KimDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of KoreaView further author information
,
Chul-Ho KimDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea;Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of KoreaView further author information
&
Yong-Sung KimDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of KoreaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2673-1509View further author information
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Article: e1438800 | Received 28 Sep 2017, Accepted 05 Feb 2018, Published online: 06 Mar 2018

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Jing Zhang, Haijing Song, Yanan Dong, Ganghui Li, Jun Li, Qizhe Cai, Shoujun Yuan, Yi Wang & Haifeng Song. (2023) Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma. International Journal of Nanomedicine 18, pages 209-223.
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Articles from other publishers (20)

Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Jose Gonzalez-Gomariz, Celia Gomar, Joan Salvador Russo-Cabrera, Irene Olivera, Assunta Cirella, Myriam Fernandez-Sendin, Maite Alvarez, Alvaro Teijeira, Cigdem Atay, José Medina-Echeverz, Maria Hinterberger, Hubertus Hochrein, Ignacio Melero, Pedro Berraondo & Fernando Aranda. (2023) Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis. Journal for ImmunoTherapy of Cancer 11:11, pages e006702.
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Luciano Santollani & K. Dane Wittrup. (2023) Spatiotemporally programming cytokine immunotherapies through protein engineering. Immunological Reviews 320:1, pages 10-28.
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Yong Fu, Renhong Tang & Xiaofeng Zhao. (2023) Engineering cytokines for cancer immunotherapy: a systematic review. Frontiers in Immunology 14.
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Jeaneen Venkatas & Moganavelli Singh. (2023) Curcumin-reduced gold nanoparticles facilitate IL-12 delivery to a cervical cancer in vitro cell model . Nanomedicine 18:13, pages 945-960.
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Eva Gutierrez, Mitchell Bigelow, Colin LaCroix, Jeremy Beech, Patrick Kirby, Lynn Markowitz, Michael Shifrin, Michael Naill, Alexandra Braun, Steve O’Neil, Jean-Marie Cuillerot, Ann Cheung, Asya Grinberg & Nicolai Wagtmann. (2023) An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses. Med 4:5, pages 326-340.e5.
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Pengwen Chen, Wenqian Yang, Koji Nagaoka, George Lo Huang, Takuya Miyazaki, Taehun Hong, Shangwei Li, Kazunori Igarashi, Kazuyoshi Takeda, Kazuhiro Kakimi, Kazunori Kataoka & Horacio Cabral. (2023) An IL‐12‐Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors. Advanced Science 10:10.
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Theint Aung, William S. Grubbe, Rebecca J. Nusbaum & Juan L. Mendoza. (2023) Recent and future perspectives on engineering interferons and other cytokines as therapeutics. Trends in Biochemical Sciences 48:3, pages 259-273.
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Natalie K. Wolf, Djem U. Kissiov & David H. Raulet. (2022) Roles of natural killer cells in immunity to cancer, and applications to immunotherapy. Nature Reviews Immunology 23:2, pages 90-105.
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Nourridine Siewe & Avner Friedman. (2023) Cancer therapy with immune checkpoint inhibitor and CSF-1 blockade: A mathematical model. Journal of Theoretical Biology 556, pages 111297.
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Hongbin Wang, Tuan T. Tran, Katherine T. Duong, Trieu Nguyen & Uyen M. Le. (2022) Options of Therapeutics and Novel Delivery Systems of Drugs for the Treatment of Melanoma. Molecular Pharmaceutics 19:12, pages 4487-4505.
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Keunok Jung, Min-Jeong Son, Se-Young Lee, Jeong-Ah Kim, Deok-Han Ko, Sojung Yoo, Chul-Ho Kim & Yong-Sung Kim. (2022) Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8+ T cells for cancer immunotherapy. Molecular Cancer 21:1.
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Nourridine Siewe & Avner Friedman. (2022) Optimal timing of steroid initiation in response to CTLA-4 antibody in metastatic cancer: A mathematical model. PLOS ONE 17:11, pages e0277248.
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Keunok Jung, Sojung Yoo, Jung-Eun Kim, Wook Kim & Yong-Sung Kim. (2022) Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy. Frontiers in Immunology 13.
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Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin & Robert F. Graziano. (2022) Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses. Drug Metabolism and Disposition 50:7, pages 898-908.
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Behzad Baradaran, Ali Mohammadi, Sara Shamekhi, Nikoo Majidazar, Azita Dilmaghani, Saiedeh Razi Soofiyani, Nigel AJ McMillan, Farzaneh Lotfipour & Somayeh Hallaj-Nezhadi. (2021) A novel method for the development of plasmid DNA-loaded nanoliposomes for cancer gene therapy. Drug Delivery and Translational Research 12:6, pages 1508-1520.
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Patrick G. Holder, Shion A. Lim, Christine S. Huang, Preeti Sharma, Yavuz S. Dagdas, Beyza Bulutoglu & Jonathan T. Sockolosky. (2022) Engineering interferons and interleukins for cancer immunotherapy. Advanced Drug Delivery Reviews 182, pages 114112.
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Aslan Mansurov, Abigail Lauterbach, Erica Budina, Aaron T. Alpar, Jeffrey A. Hubbell & Jun Ishihara. (2021) Immunoengineering approaches for cytokine therapy. American Journal of Physiology-Cell Physiology 321:2, pages C369-C383.
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Keunok Jung, Jeong-Ah Kim, Ye-Jin Kim, Hyun Woo Lee, Chul-Ho Kim, Seokjin Haam & Yong-Sung Kim. (2020) A Neuropilin-1 Antagonist Exerts Antitumor Immunity by Inhibiting the Suppressive Function of Intratumoral Regulatory T Cells. Cancer Immunology Research 8:1, pages 46-56.
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Xutong Shen, Qingqing Li, Fanwen Wang, Jingxiao Bao, Mengting Dai, Heng Zheng & Xingzhen Lao. (2018) Generation of a novel long-acting thymosin alpha1-Fc fusion protein and its efficacy for the inhibition of breast cancer in vivo. Biomedicine & Pharmacotherapy 108, pages 610-617.
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Zunqiang Yan, Xiaoyu Huang, Wenyang Sun, Qiaoli Yang, Hairen Shi, Tiantuan Jiang, Shenggui Li, Pengfei Wang & Shuangbao Gun. (2018) Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused by Clostridium perfringens type C . PeerJ 6, pages e5997.
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