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OncoImmunology Volume 7, 2018 - Issue 7
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Original Research

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

Martin BöttcherDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2911-8830View further author information
ORCID Icon,
Kathrin RennerInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyView further author information
,
Raffaela BergerInstitute of Functional Genomics, University of Regensburg, Regensburg, GermanyView further author information
,
Kristin MentzDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyView further author information
,
Simone ThomasInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyORCID Iconhttp://orcid.org/0000-0001-6308-3649View further author information
ORCID Icon,
Zugey Elizabeth Cardenas-ConejoInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyView further author information
,
Katja DettmerInstitute of Functional Genomics, University of Regensburg, Regensburg, GermanyView further author information
,
Peter J. OefnerInstitute of Functional Genomics, University of Regensburg, Regensburg, GermanyView further author information
,
Andreas MackensenDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyView further author information
,
Marina KreutzInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyView further author information
&
Dimitrios MougiakakosDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyView further author information
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Article: e1445454 | Received 15 Dec 2017, Accepted 21 Feb 2018, Published online: 26 Mar 2018

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Leland G. Richardson, Linda T. Nieman, Anat O. Stemmer-Rachamimov, Xijin S. Zheng, Khalifa Stafford, Hiroaki Nagashima, Julie J. Miller, Juri Kiyokawa, David T. Ting, Hiroaki Wakimoto, Daniel P. Cahill, Bryan D. Choi & William T. Curry. (2020) IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice. OncoImmunology 9:1.
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Lorenzo Galluzzi & Guido Kroemer. (2018) Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate. OncoImmunology 7:12.
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