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Original Research

A novel bispecific antibody for EGFR-directed blockade of the PD-1/PD-L1 immune checkpoint

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Article: e1466016 | Received 24 Jan 2018, Accepted 11 Apr 2018, Published online: 31 May 2018

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Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz & Luis Álvarez-Vallina. (2023) A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response. OncoImmunology 12:1.
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Cong-Li Jia, Fu Yang & Rui-Ning Li. (2022) Identification of Potential Core Genes Between Primary and Metastatic Malignant Melanoma and Analysis of Their Immune Correlation. International Journal of General Medicine 15, pages 379-391.
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Jorge Cebada, Amira Flores, Cindy Bandala, Ian Lizaliturri-Flores, Nemesio Villa-Ruano & Martin Perez-Santos. (2020) Bispecific anti-PD-1/LAG-3 antibodies for treatment of advanced or metastatic solid tumors: a patent evaluation of US2018326054. Expert Opinion on Therapeutic Patents 30:7, pages 487-494.
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Mark A. J. M. Hendriks, Emily M. Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F. Samplonius & Wijnand Helfrich. (2020) Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation. OncoImmunology 9:1.
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Martin Perez-Santos, Maricruz Anaya-Ruiz, Irma Herrera-Camacho, Lourdes Millán-Pérez Peña & Nora Hilda Rosas-Murrieta. (2019) Bispecific anti-OX40/CTLA-4 antibodies for advanced solid tumors: a patent evaluation of WO2018202649. Expert Opinion on Therapeutic Patents 29:12, pages 921-924.
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Jonathan G. Pol, Sarah Lévesque, Samuel T. Workenhe, Shashi Gujar, Fabrice Le Boeuf, Derek R. Clements, Jean-Eudes Fahrner, Laetitia Fend, John C. Bell, Karen L. Mossman, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2018) Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors. OncoImmunology 7:12.
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