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OncoImmunology Volume 7, 2018 - Issue 9
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Original Research

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

Roy XiaoCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA;Medical Research Scholars Program, National Institutes of Health, Bethesda, MD, USA;Tumor Biology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0003-4459-0746View further author information
ORCID Icon,
Clint T. AllenNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA;Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USAView further author information
,
Linda TranNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0001-7080-5320View further author information
ORCID Icon,
Priya PatelMedical Research Scholars Program, National Institutes of Health, Bethesda, MD, USA;Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USAView further author information
,
So-Jin ParkNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USAView further author information
,
Zhong ChenTumor Biology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USAView further author information
,
Carter Van WaesTumor Biology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USAView further author information
&
Nicole C. SchmittNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA;Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USACorrespondence[email protected]
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Article: e1471440 | Received 22 Dec 2017, Accepted 27 Apr 2018, Published online: 01 Aug 2018

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Kosei Nakajima, Yoshinori Ino, Rie Yamazaki-Itoh, Chie Naito, Mari Shimasaki, Mami Takahashi, Minoru Esaki, Satoshi Nara, Yoji Kishi, Kazuaki Shimada & Nobuyoshi Hiraoka. (2020) IAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunity. OncoImmunology 9:1.
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Wenda Ye, Sreenivasulu Gunti, Clint T. Allen, Youji Hong, Paul E. Clavijo, Carter Van Waes & Nicole C. Schmitt. (2020) ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer. OncoImmunology 9:1.
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