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OncoImmunology Volume 7, 2018 - Issue 10
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Original Research

Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy

Charlotte M. MoussetDepartment of Laboratory Medicine - Laboratory of Hematology; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The NetherlandsCorrespondence[email protected]
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Willemijn HoboDepartment of Laboratory Medicine - Laboratory of Hematology; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttp://orcid.org/0000-0002-8206-8185View further author information
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Yun JiExperimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0001-6340-7009View further author information
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Hanny FredrixDepartment of Laboratory Medicine - Laboratory of Hematology; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The NetherlandsView further author information
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Valeria De GiorgiInfectious Diseases Section, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0001-5296-8628View further author information
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Robert D. AllisonInfectious Diseases Section, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0001-8458-5250View further author information
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Michel G. D. KesterDepartment of Hematology - Laboratory of Experimental Hematology, Leiden University Medical Center, Leiden, The NetherlandsView further author information
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J. H. Frederik FalkenburgDepartment of Hematology - Laboratory of Experimental Hematology, Leiden University Medical Center, Leiden, The NetherlandsORCID Iconhttp://orcid.org/0000-0002-9819-4813View further author information
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Nicolaas P. M. SchaapDepartment of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttp://orcid.org/0000-0001-7696-4752View further author information
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Joop H. JansenDepartment of Laboratory Medicine - Laboratory of Hematology; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttp://orcid.org/0000-0001-9459-568XView further author information
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Luca GattinoniExperimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0003-2239-3282View further author information
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Harry DolstraDepartment of Laboratory Medicine - Laboratory of Hematology; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttp://orcid.org/0000-0002-3998-687XView further author information
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Anniek B. van der WaartDepartment of Laboratory Medicine - Laboratory of Hematology; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttp://orcid.org/0000-0001-5986-3060View further author information
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Article: e1488565 | Received 14 May 2018, Accepted 11 Jun 2018, Published online: 06 Aug 2018

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Makoto Ando, Minako Ito, Tanakorn Srirat, Taisuke Kondo & Akihiko Yoshimura. (2020) Memory T cell, exhaustion, and tumor immunity. Immunological Medicine 43:1, pages 1-9.
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