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OncoImmunology Volume 7, 2018 - Issue 12

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Original Research

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

Sietse J LukDepartment of Hematology, Leiden University Medical Center, Leiden, The NetherlandsCorrespondence[email protected]
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Dirk M van der SteenDepartment of Hematology, Leiden University Medical Center, Leiden, The NetherlandsView further author information

Renate S HagedoornDepartment of Hematology, Leiden University Medical Center, Leiden, The NetherlandsView further author information

Ekaterina S JordanovaDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands;Center for Gynecological Oncology Amsterdam, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The NetherlandsView further author information

Marco W SchilhamDepartment of Pediatrics, Leiden University Medical Center, Leiden, The NetherlandsView further author information

Judith VMG BovéeDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands

http://orcid.org/0000-0003-1155-0481 View further author information

Arjen HG ClevenDepartment of Pathology, Leiden University Medical Center, Leiden, The NetherlandsView further author information

JH Frederik FalkenburgDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands

http://orcid.org/0000-0002-9819-4813 View further author information

Karoly SzuhaiDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

http://orcid.org/0000-0002-1228-4245 View further author information

Mirjam HM HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, The NetherlandsView further author information

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Article: e1507600 | Received 14 Jun 2018, Accepted 01 Aug 2018, Published online: 11 Sep 2018

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https://doi.org/10.1080/2162402X.2018.1507600
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Lorena Landuzzi, Maria Cristina Manara, Laura Pazzaglia, Pier-Luigi Lollini & Katia Scotlandi. (2023) Innovative Breakthroughs for the Treatment of Advanced and Metastatic Synovial Sarcoma. Cancers 15:15, pages 3887.
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Lauren B. BanksSandra P. D’Angelo. (2022) The Role of Immunotherapy in the Management of Soft Tissue Sarcomas: Current Landscape and Future Outlook. Journal of the National Comprehensive Cancer Network 20:7, pages 834-844.
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Preethika Mahalingam, Maximilian Julve, Paul Huang, Andrew J.S. Furness, Seth M. Pollack & Robin L. Jones. (2022) Immunotherapy of sarcomas with modified T cells. Current Opinion in Oncology 34:4, pages 362-370.
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Nadja Sailer, Ina Fetzer, Melanie Salvermoser, Monika Braun, Doris Brechtefeld, Christian Krendl, Christiane Geiger, Kathrin Mutze, Elfriede Noessner, Dolores Schendel, Maja Bürdek, Susanne Wilde & Daniel Sommermeyer. (2022) T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity. Cancers 14:8, pages 1998.
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Gerardo Cazzato, Katia Mangialardi, Giovanni Falcicchio, Anna Colagrande, Giuseppe Ingravallo, Francesca Arezzo, Giovanna Giliberti, Irma Trilli, Vera Loizzi, Teresa Lettini, Sara Scarcella, Tiziana Annese, Paola Parente, Carmelo Lupo, Nadia Casatta, Eugenio Maiorano, Gennaro Cormio, Leonardo Resta & Domenico Ribatti. (2022) Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study. Genes 13:3, pages 545.
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Maciej Kaczorowski, Małgorzata Chłopek, Anna Kruczak, Janusz Ryś, Jerzy Lasota & Markku Miettinen. (2022) PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors. American Journal of Surgical Pathology Publish Ahead of Print.
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Fan Tang, Yan Tie, Yu-Quan Wei, Chong-Qi Tu & Xia-Wei Wei. (2021) Targeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:2, pages 188606.
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Andrew S. Brohl, Sivasish Sindiri, Jun S. Wei, David Milewski, Hsien-Chao Chou, Young K. Song, Xinyu Wen, Jeetendra Kumar, Hue V. Reardon, Uma S. Mudunuri, Jack R. Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J. Zhu, Katherine E. Masih, Marielle E. Yohe, Jack F. Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J. Orentas, Igor B. Kuznetsov, Nicolas J. Llosa, John A. Ligon, Brian K. Turpin, Daniel G. Leino, Shintaro Iwata, Irene L. Andrulis, Jay S. Wunder, Silvia R.C. Toledo, Paul S. Meltzer, Ching Lau, Beverly A. Teicher, Heather Magnan, Marc Ladanyi & Javed Khan. (2021) Immuno-transcriptomic profiling of extracranial pediatric solid malignancies. Cell Reports 37:8, pages 110047.
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Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée & Noel F. C. C. de Miranda. (2021) Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?. Biomedicines 9:8, pages 1048.
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Geoffrey Mitchell, Seth M Pollack & Michael J Wagner. (2021) Targeting cancer testis antigens in synovial sarcoma. Journal for ImmunoTherapy of Cancer 9:6, pages e002072.
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Wei-Lien Wang, Nalan Gokgoz, Bana Samman, Irene L. Andrulis, Jay S. Wunder & Elizabeth G. Demicco. (2021) RNA expression profiling reveals PRAME, a potential immunotherapy target, is frequently expressed in solitary fibrous tumors. Modern Pathology 34:5, pages 951-960.
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Antonios Somarakis, Marieke E. Ijsselsteijn, Sietse J. Luk, Boyd Kenkhuis, Noel F.C.C. de Miranda, Boudewijn P.F. Lelieveldt & Thomas Hollt. (2021) Visual cohort comparison for spatial single-cell omics-data. IEEE Transactions on Visualization and Computer Graphics 27:2, pages 733-743.
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Jun Wang, Mingzhi Gong, Zhenggang Xiong, Yangyang Zhao & Deguo Xing. (2021) Immune-related prognostic genes signatures in the tumor microenvironment of sarcoma. Mathematical Biosciences and Engineering 18:3, pages 2243-2257.
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Cathryn R Cadwell, Gul E Yuksek, Angela C Hirbe, Divya Srihari, Phillip LeBoit, Sonika Dahiya & Melike Pekmezci. (2021) Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors. Journal of Neuropathology & Experimental Neurology 80:4, pages 384-386.
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Cesar Gentille Sanchez, Thomas Pfeiffer & Bilal A. Omer. 2021. Uveal Melanoma. Uveal Melanoma 213 225 .

Javier Martín-Broto, David S. Moura & Brian A. Van Tine. (2020) Facts and Hopes in Immunotherapy of Soft-Tissue Sarcomas. Clinical Cancer Research 26:22, pages 5801-5808.
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Ran Wei, Dylan C. Dean, Pichaya Thanindratarn, Francis J. Hornicek, Wei Guo & Zhenfeng Duan. (2020) Cancer testis antigens in sarcoma: Expression, function and immunotherapeutic application. Cancer Letters 479, pages 54-60.
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Ferga C. Gleeson, Michael J. Levy, Rory A. Jackson, Stephen J. Murphy, Kevin C. Halling, Benjamin R. Kipp, Rondell P. Graham & Lizhi Zhang. (2020) Endoscopic ultrasound may be used to deliver gene expression signatures using digital mRNA detection methods to immunophenotype pancreatic ductal adenocarcinoma to facilitate personalized immunotherapy. Pancreatology 20:2, pages 229-238.
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Ghaneya Al-Khadairi & Julie Decock. (2019) Cancer Testis Antigens and Immunotherapy: Where Do We Stand in the Targeting of PRAME?. Cancers 11:7, pages 984.
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PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

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PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

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