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Original Research

Timing of neoadjuvant immunotherapy in relation to surgery is crucial for outcome

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Article: e1581530 | Received 20 Nov 2018, Accepted 06 Feb 2019, Published online: 01 Mar 2019

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Judith M. Versluis, Georgina V. Long & Christian U. Blank. (2020) Learning from clinical trials of neoadjuvant checkpoint blockade. Nature Medicine 26:4, pages 475-484.
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Crossref
Suzanne L. Topalian, Janis M. TaubeDrew M. Pardoll. (2020) Neoadjuvant checkpoint blockade for cancer immunotherapy. Science 367:6477.
Crossref
Jake S. O'Donnell, Esmée P. Hoefsmit, Mark J. Smyth, Christian U. Blank & Michele W.L. Teng. (2019) The Promise of Neoadjuvant Immunotherapy and Surgery for Cancer Treatment. Clinical Cancer Research 25:19, pages 5743-5751.
Crossref

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