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Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

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Article: e1633235 | Received 16 May 2019, Accepted 13 Jun 2019, Published online: 25 Jun 2019

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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