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OncoImmunology Volume 9, 2020 - Issue 1
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Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation

Jay S. Wundera University of Toronto Musculoskeletal Oncology Unit, Sinai Health System, Toronto, ON, Canada;b Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada;c Department of Surgery, University of Toronto, ON, CanadaView further author information
,
Minji J. Leeb Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, CanadaView further author information
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Junghyun Namb Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada;d Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CanadaView further author information
,
Beatrice Y. Laue Department of Pathology and Laboratory Medicine, Sinai Health System, Toronto, ON, CanadaView further author information
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Brendan C. Dicksona University of Toronto Musculoskeletal Oncology Unit, Sinai Health System, Toronto, ON, Canada;d Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;e Department of Pathology and Laboratory Medicine, Sinai Health System, Toronto, ON, CanadaView further author information
,
Dushanthi Pinnaduwageb Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, CanadaView further author information
,
Shelley B. Bullb Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada;f Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaView further author information
,
Peter C. Fergusona University of Toronto Musculoskeletal Oncology Unit, Sinai Health System, Toronto, ON, Canada;c Department of Surgery, University of Toronto, ON, CanadaView further author information
,
Andrew Setob Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, CanadaView further author information
,
Nalan Gokgozb Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, CanadaView further author information
&
Irene L. Andrulisb Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada;d Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;g Department of Molecular Genetics, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]
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Article: 1737385 | Received 04 Feb 2019, Accepted 22 Jan 2020, Published online: 18 Mar 2020

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Helena Nyström, Mats Jönsson, Mef Nilbert & Ana Carneiro. (2023) Immune-cell infiltration in high-grade soft tissue sarcomas; prognostic implications of tumor-associated macrophages and B-cells. Acta Oncologica 62:1, pages 33-39.
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Articles from other publishers (21)

Kang qiang Weng, Jin Yu Liu, Hu Li, Lin Lu She, Jun Liang Qiu, Hao Qi, Hui Yue Qi, Yong Sheng Li & Ying bo Dai. (2024) Identification of Treg-related prognostic molecular subtypes and individualized characteristics in clear cell renal cell carcinoma through single-cell transcriptomes and bulk RNA sequencing. International Immunopharmacology 130, pages 111746.
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H.M. Abd Elmoneim, H.F. Huwait, H. Nafady-Hego & FEZ.A. Mohamed. (2023) PROGNOSTIC IMPLICATIONS OF PD-L1 EXPRESSION AND LOSS OF PTEN IN PATIENTS WITH RHABDOMYOSARCOMA, EWING’S SARCOMA AND OSTEOSARCOMA. Experimental Oncology 45:3, pages 337-350.
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Jun Nishio & Shizuhide Nakayama. (2023) Biology and Management of High-Grade Myxofibrosarcoma: State of the Art and Future Perspectives. Diagnostics 13:19, pages 3022.
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Joshua D. Mannheimer, Gregory Tawa, David Gerhold, John Braisted, Carly M. Sayers, Troy A. McEachron, Paul Meltzer, Christina Mazcko, Jessica A. Beck & Amy K. LeBlanc. (2023) Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans. Communications Biology 6:1.
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My Linh D Vu, Andrew Berman, Erica Kao, Kristin Stoll & Lauren Lee. (2023) Safe and effective use of cabozantinib and nivolumab in stabilizing disease progression of tissue sarcoma after multiple lines of standard therapy. Journal of Case Reports and Images in Oncology 9:2, pages 1-6.
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Manuel Sánchez-de-la-Torre, Carolina Cubillos, Olivia J. Veatch, Francisco Garcia-Rio, David Gozal & Miguel Angel Martinez-Garcia. (2023) Potential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer. Cancers 15:4, pages 1061.
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Wei Wu, Haoyu Guo, Doudou Jing, Zhenhao Zhang, Zhicai Zhang, Feifei Pu, Wenbo Yang, Xin Jin, Xin Huang & Zengwu Shao. (2022) Targeted Delivery of PD‐L1‐Derived Phosphorylation‐Mimicking Peptides by Engineered Biomimetic Nanovesicles to Enhance Osteosarcoma Treatment. Advanced Healthcare Materials 11:23.
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Carolina Cubillos-Zapata, Elena Díaz-García & Francisco García-Río. 2022. Lung Diseases and Cancer. Lung Diseases and Cancer 1 14 .
Yang Wen, Fan Tang, Chongqi Tu, Francis Hornicek, Zhenfeng Duan & Li Min. (2022) Immune checkpoints in osteosarcoma: Recent advances and therapeutic potential. Cancer Letters 547, pages 215887.
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Liyan Qu, Jiakang Jin, Jianan Lou, Chao Qian, Jinti Lin, Ankai Xu, Bing Liu, Man Zhang, Huimin Tao & Wei Yu. (2022) The nuclear transportation of PD-L1 and the function in tumor immunity and progression. Cancer Immunology, Immunotherapy 71:10, pages 2313-2323.
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Antonia Resag, Giulia Toffanin, Iva Benešová, Luise Müller, Vlatko Potkrajcic, Andrej Ozaniak, Robert Lischke, Jirina Bartunkova, Antonio Rosato, Korinna Jöhrens, Franziska Eckert, Zuzana Strizova & Marc Schmitz. (2022) The Immune Contexture of Liposarcoma and Its Clinical Implications. Cancers 14:19, pages 4578.
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Kazuhiko Hashimoto, Shunji NishimuraYu ShinyashikiTomohiko ItoHiroki TanakaKazuhiro OhtaniRyosuke KakinokiMasao Akagi. (2022) PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in cutaneous angiosarcoma: A case report. Medicine 101:28, pages e29621.
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Alice Ko, Victoria S. Coward, Nalan Gokgoz, Brendan C. Dickson, Kim Tsoi, Jay S. Wunder & Irene L. Andrulis. (2022) Investigating the Potential of Isolating and Expanding Tumour-Infiltrating Lymphocytes from Adult Sarcoma. Cancers 14:3, pages 548.
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Matthieu Roulleaux Dugage, Elise F. Nassif, Antoine Italiano & Rastislav Bahleda. (2021) Improving Immunotherapy Efficacy in Soft-Tissue Sarcomas: A Biomarker Driven and Histotype Tailored Review. Frontiers in Immunology 12.
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Andrew S. Brohl, Sivasish Sindiri, Jun S. Wei, David Milewski, Hsien-Chao Chou, Young K. Song, Xinyu Wen, Jeetendra Kumar, Hue V. Reardon, Uma S. Mudunuri, Jack R. Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J. Zhu, Katherine E. Masih, Marielle E. Yohe, Jack F. Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J. Orentas, Igor B. Kuznetsov, Nicolas J. Llosa, John A. Ligon, Brian K. Turpin, Daniel G. Leino, Shintaro Iwata, Irene L. Andrulis, Jay S. Wunder, Silvia R.C. Toledo, Paul S. Meltzer, Ching Lau, Beverly A. Teicher, Heather Magnan, Marc Ladanyi & Javed Khan. (2021) Immuno-transcriptomic profiling of extracranial pediatric solid malignancies. Cell Reports 37:8, pages 110047.
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Zeger Rijs, Bernadette Jeremiasse, Naweed Shifai, Hans Gelderblom, Cornelis F. M. Sier, Alexander L. Vahrmeijer, Fijs W. B. van Leeuwen, Alida F. W. van der Steeg & Michiel A. J. van de Sande. (2021) Introducing Fluorescence-Guided Surgery for Pediatric Ewing, Osteo-, and Rhabdomyosarcomas: A Literature Review. Biomedicines 9:10, pages 1388.
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Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée & Noel F. C. C. de Miranda. (2021) Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?. Biomedicines 9:8, pages 1048.
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Luana Madalena Sousa, Jani Sofia Almeida, Tânia Fortes-Andrade, Manuel Santos-Rosa, Paulo Freitas-Tavares, José Manuel Casanova & Paulo Rodrigues-Santos. (2021) Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy. Cancers 13:15, pages 3885.
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Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito & Masao Akagi. (2021) Characterization of PD-1/PD-L1 immune checkpoint expression in soft tissue sarcomas. European Journal of Histochemistry 65:3.
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Mayanne M.T. Zhu, Elahe Shenasa & Torsten O. Nielsen. (2020) Sarcomas: Immune biomarker expression and checkpoint inhibitor trials. Cancer Treatment Reviews 91, pages 102115.
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