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Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions

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Article: 1747677 | Received 19 Aug 2019, Accepted 14 Mar 2020, Published online: 12 Apr 2020

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Qiu-Ping Liu, Yu-Ying Chen, Pei An, Khalid Rahman, Xin Luan & Hong Zhang. (2023) Natural products targeting macrophages in tumor microenvironment are a source of potential antitumor agents. Phytomedicine 109, pages 154612.
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Jiaji Yue, Zhe-Sheng Chen, Xiang-Xi Xu & Shenglong Li. (2022) Functions and therapeutic potentials of exosomes in osteosarcoma. Acta Materia Medica 1:4.
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Siqi Wang, Jiaxin Sun, Raha M. Dastgheyb & Zhigang Li. (2022) Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression. Frontiers in Immunology 13.
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Tianyi Zhu, Jing Han, Liu Yang, Zhengdong Cai, Wei Sun, Yingqi Hua & Jing Xu. (2022) Immune Microenvironment in Osteosarcoma: Components, Therapeutic Strategies and Clinical Applications. Frontiers in Immunology 13.
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Yubao Lu, Jiahe Zhang, Yutong Chen, Yuchen Kang, Zhipeng Liao, Yuanqi He & Cangyu Zhang. (2022) Novel Immunotherapies for Osteosarcoma. Frontiers in Oncology 12.
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Crossref
Yue Yang & Yun Wang. 2023. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 177 198 .
Shenglong Li. (2021) The basic characteristics of extracellular vesicles and their potential application in bone sarcomas. Journal of Nanobiotechnology 19:1.
Crossref
BingZhang Tian, Lixue Zhou, Jun Wang & Pingzhou Yang. (2021) miR-660-5p-loaded M2 macrophages-derived exosomes augment hepatocellular carcinoma development through regulating KLF3. International Immunopharmacology 101, pages 108157.
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Eugenie S. Kleinerman. (2021) Meet the Editorial Board Member. Cardiovascular & Hematological Disorders-Drug Targets 21:2, pages 87-87.
Crossref
Lingkai Yang, Xin Huang, Haoyu Guo, Lutong Wang, Wenbo Yang, Wei Wu, Doudou Jing & Zengwu Shao. (2021) Exosomes as Efficient Nanocarriers in Osteosarcoma: Biological Functions and Potential Clinical Applications. Frontiers in Cell and Developmental Biology 9.
Crossref
Jonathan Gill & Richard Gorlick. (2021) Advancing therapy for osteosarcoma. Nature Reviews Clinical Oncology 18:10, pages 609-624.
Crossref
Tuo Liang, Jiarui Chen, GuoYong Xu, Zide Zhang, Jiang Xue, Haopeng Zeng, Jie Jiang, Tianyou Chen, Zhaojie Qin, Hao Li, Zhen Ye, Yunfeng Nie, Chong Liu & Xinli Zhan. (2021) TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma. Scientific Reports 11:1.
Crossref
Alfredo Cappariello & Nadia Rucci. (2021) Extracellular Vesicles in Bone Tumors: How to Seed in the Surroundings Molecular Information for Malignant Transformation and Progression. Frontiers in Oncology 11.
Crossref
Qingshan Huang, Xin Liang, Tingting Ren, Yi Huang, Hongliang Zhang, Yiyang Yu, Chenglong Chen, Wei Wang, Jianfang Niu, Jingbing Lou & Wei Guo. (2021) The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implications. Cellular Oncology 44:3, pages 525-539.
Crossref
Chenglong Chen, Lu Xie, Tingting Ren, Yi Huang, Jie Xu & Wei Guo. (2021) Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs. Cancer Letters 500, pages 1-10.
Crossref
Zhonghua Cheng, Liqin Wang, Chenhuan Wu, Lin Huang, Yuan Ruan & Wei Xue. (2021) Tumor-derived Exosomes Induced M2 Macrophage Polarization and Promoted the Metastasis of Osteosarcoma Cells Through Tim-3. Archives of Medical Research 52:2, pages 200-210.
Crossref
Fernanda G. Kugeratski & Raghu Kalluri. (2020) Exosomes as mediators of immune regulation and immunotherapy in cancer. The FEBS Journal 288:1, pages 10-35.
Crossref
Zhiyu Chen, Huanhuan Huang, Yang Wang, Fangbiao Zhan & Zhengxue Quan. (2020) Identification of Immune-Related Genes MSR1 and TLR7 in Relation to Macrophage and Type-2 T-Helper Cells in Osteosarcoma Tumor Micro-Environments as Anti-metastasis Signatures. Frontiers in Molecular Biosciences 7.
Crossref
Zhong-Wei Luo, Pan-Pan Liu, Zhen-Xing Wang, Chun-Yuan Chen & Hui Xie. (2020) Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy. Frontiers in Oncology 10.
Crossref
Sara Busatto, Yubo Yang, Sierra A. Walker, Irina Davidovich, Wan-Hsin Lin, Laura Lewis-Tuffin, Panagiotis Z. Anastasiadis, Jann Sarkaria, Yeshayahu Talmon, Gregory Wurtz & Joy Wolfram. (2020) Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein. Journal of Nanobiotechnology 18:1.
Crossref
Ying Chen, Bo Zhao & Xiaohu Wang. (2020) Tumor infiltrating immune cells (TIICs) as a biomarker for prognosis benefits in patients with osteosarcoma. BMC Cancer 20:1.
Crossref
Alekhya Mazumdar, Joaquin Urdinez, Aleksandar Boro, Matthias J. E. Arlt, Fabian E. Egli, Barbara Niederöst, Patrick K. Jaeger, Greta Moschini, Roman Muff, Bruno Fuchs, Jess G. Snedeker & Ana Gvozdenovic. (2020) Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model. Cancers 12:11, pages 3457.
Crossref
Bibek Bhatta & Tomer Cooks. (2020) Reshaping the tumor microenvironment: extracellular vesicles as messengers of cancer cells. Carcinogenesis 41:11, pages 1461-1470.
Crossref
Alekhya Mazumdar, Joaquin Urdinez, Aleksandar Boro, Jessica Migliavacca, Matthias J.E. Arlt, Roman Muff, Bruno Fuchs, Jess Gerrit Snedeker & Ana Gvozdenovic. (2020) Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming. International Journal of Molecular Sciences 21:15, pages 5451.
Crossref
Francesca Cersosimo, Silvia Lonardi, Giulia Bernardini, Brian Telfer, Giulio Eugenio Mandelli, Annalisa Santucci, William Vermi & Emanuele Giurisato. (2020) Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy. International Journal of Molecular Sciences 21:15, pages 5207.
Crossref