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OncoImmunology Volume 9, 2020 - Issue 1
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Hypoxia increases mutational load of breast cancer cells through frameshift mutations

Goutham Hassan Venkatesha Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0002-6520-435XView further author information
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Pamela Bravob INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Faculty of Medicine, University Paris-Saclay, Villejuif, FranceORCID Iconhttps://orcid.org/0000-0003-4778-5039View further author information
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Walid Shaaban Moustafa Elsayeda Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates;c Department of Oral Biology, College of Dentistry, Gulf Medical University, Ajman, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0002-6647-516XView further author information
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Francis Amirtharaja Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0001-6862-2875View further author information
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Bartosz Wojtasd Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, PAS, 02-093, Warsaw, PolandORCID Iconhttps://orcid.org/0000-0002-9967-910XView further author information
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Raefa Abou Khouzama Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab EmiratesORCID Iconhttps://orcid.org/0000-0003-0037-6000View further author information
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Husam Hussein Nawafleha Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab EmiratesView further author information
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Sandeep Mallyae Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaView further author information
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Kapaettu Satyamoorthye Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaView further author information
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Philippe Dessenf Bioinformatic Core Facility, INSERM US23/CNRS UMS3655, Gustave Roussy Cancer Campus, Villejuif, FranceORCID Iconhttps://orcid.org/0000-0002-4799-5071View further author information
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Filippo Rossellig CNRS UMR9019, Genome Integrity and Cancers, Gustave Roussy, Villejuif, FranceORCID Iconhttps://orcid.org/0000-0003-1080-5745View further author information
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Jerome Thieryb INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Faculty of Medicine, University Paris-Saclay, Villejuif, FranceORCID Iconhttps://orcid.org/0000-0002-0998-3627View further author information
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Salem Chouaiba Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates;b INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Faculty of Medicine, University Paris-Saclay, Villejuif, FranceCorrespondence[email protected] [email protected]
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Article: 1750750 | Received 30 Dec 2019, Accepted 12 Mar 2020, Published online: 16 Apr 2020

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Goutham Hassan Venkatesh, Raefa Abou Khouzam, Walid Shaaban Moustafa Elsayed, Nagwa Ahmed Zeinelabdin, Stéphane Terry & Salem Chouaib. (2021) Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?. OncoImmunology 10:1.
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An‐Qi Li & Jian‐Hong Fang. (2024) Anti‐angiogenic therapy enhances cancer immunotherapy: Mechanism and clinical application. Interdisciplinary Medicine 2:1.
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Raefa Abou Khouzam, Bassam Janji, Jerome Thiery, Rania Faouzi Zaarour, Ali N. Chamseddine, Hemma Mayr, Pierre Savagner, Claudine Kieda, Sophie Gad, Stéphanie Buart, Jean–Marie Lehn, Perparim Limani & Salem Chouaib. (2023) Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy. Seminars in Cancer Biology 97, pages 104-123.
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Teow J. Phua. (2023) Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis. Frontiers in Aging 4.
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Julien Schmidt, Johanna Chiffelle, Marta A. S. Perez, Morgane Magnin, Sara Bobisse, Marion Arnaud, Raphael Genolet, Julien Cesbron, David Barras, Blanca Navarro Rodrigo, Fabrizio Benedetti, Alexandra Michel, Lise Queiroz, Petra Baumgaertner, Philippe Guillaume, Michael Hebeisen, Olivier Michielin, Tu Nguyen-Ngoc, Florian Huber, Melita Irving, Stéphanie Tissot-Renaud, Brian J. Stevenson, Sylvie Rusakiewicz, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Nathalie Rufer, David Gfeller, Lana E. Kandalaft, Daniel E. Speiser, Vincent Zoete, George Coukos & Alexandre Harari. (2023) Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors. Nature Communications 14:1.
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Raefa Abou Khouzam, Mohak Sharda, Shyama Prasad Rao, Stephanie Maame Kyerewah-Kersi, Nagwa Ahmed Zeinelabdin, Ayda Shah Mahmood, Husam Nawafleh, Munazza Samar Khan, Goutham Hassan Venkatesh & Salem Chouaib. (2023) Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells. Frontiers in Cell and Developmental Biology 11.
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Raefa Abou Khouzam, Jean-Marie Lehn, Hemma Mayr, Pierre-Alain Clavien, Michael Bradley Wallace, Michel Ducreux, Perparim Limani & Salem Chouaib. (2023) Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy. Cancers 15:4, pages 1235.
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Lecai Xiong, Xueyu He, Le Wang, Peng Dai, Jinping Zhao, Xuefeng Zhou & Hexiao Tang. (2022) Hypoxia-associated prognostic markers and competing endogenous RNA coexpression networks in lung adenocarcinoma. Scientific Reports 12:1.
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Nandita M. deSouza, Ananya Choudhury, Mel Greaves, James P. B. O’Connor & Peter J. Hoskin. (2022) Imaging hypoxia in endometrial cancer: How and why should it be done?. Frontiers in Oncology 12.
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Raefa Abou Khouzam, Rania Faouzi Zaarour, Klaudia Brodaczewska, Bilal Azakir, Goutham Hassan Venkatesh, Jerome Thiery, Stéphane Terry & Salem Chouaib. (2022) The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes?. Frontiers in Immunology 13.
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Shan Liu, Jumpei Washio, Satoko Sato, Yuki Abiko, Yuta Shinohara, Yuri Kobayashi, Haruki Otani, Shiori Sasaki, Xiaoyi Wang & Nobuhiro Takahashi. (2022) Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions. International Journal of Molecular Sciences 23:2, pages 989.
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Yongkang Yang, Haiquan Lu, Chelsey Chen, Yajing Lyu, Robert N. Cole & Gregg L. Semenza. (2022) HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nature Communications 13:1.
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Chun Li, Lucy Wiseman, Ene Okoh, Michael Lind, Rajarshi Roy, Andrew W. Beavis & Isabel M. Pires. (2022) Exploring hypoxic biology to improve radiotherapy outcomes. Expert Reviews in Molecular Medicine 24.
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Raefa Abou Khouzam, Shyama Prasad Rao, Goutham Hassan Venkatesh, Nagwa Ahmed Zeinelabdin, Stephanie Buart, Maxime Meylan, Manjunath Nimmakayalu, Stéphane Terry & Salem Chouaib. (2021) An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment. Frontiers in Immunology 12.
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Ming Tang, Emma Bolderson, Kenneth J. O’Byrne & Derek J. Richard. (2021) Tumor Hypoxia Drives Genomic Instability. Frontiers in Cell and Developmental Biology 9.
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Barrie Peck, Philip Bland, Ioanna Mavrommati, Gareth Muirhead, Hannah Cottom, Patty T. Wai, Sarah L. Maguire, Holly E. Barker, Eamonn Morrison, Divya Kriplani, Lu Yu, Amy Gibson, Giulia Falgari, Keith Brennan, Gillian Farnie, Richard Buus, Rebecca Marlow, Daniela Novo, Eleanor Knight, Naomi Guppy, Daniela Kolarevic, Snezana Susnjar, Natasa Medic Milijic, Kalnisha Naidoo, Patrycja Gazinska, Ioannis Roxanis, Sunil Pancholi, Lesley-Ann Martin, Erle M. Holgersen, Maggie C.U. Cheang, Farzana Noor, Sophie Postel-Vinay, Gerard Quinn, Simon McDade, Lukas Krasny, Paul Huang, Frances Daley, Fredrik Wallberg, Jyoti S. Choudhary, Syed Haider, Andrew N. Tutt & Rachael Natrajan. (2021) 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer. Cancer Research 81:4, pages 847-859.
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Aitziber Buqué, Maria Perez-Lanzón, Giulia Petroni, Juliette Humeau, Norma Bloy, Takahiro Yamazaki, Ai Sato, Guido Kroemer & Lorenzo Galluzzi. 2021. Carcinogen-driven mouse models of oncogenesis. Carcinogen-driven mouse models of oncogenesis 1 19 .
Urbain Weyemi & Lorenzo Galluzzi. 2021. Chromatin and Genomic Instability in Cancer. Chromatin and Genomic Instability in Cancer ix xvii .
Stéphane Terry, Agnete S.T. Engelsen, Stéphanie Buart, Walid Shaaban Elsayed, Goutham Hassan Venkatesh & Salem Chouaib. (2020) Hypoxia-driven intratumor heterogeneity and immune evasion. Cancer Letters 492, pages 1-10.
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