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OncoImmunology Volume 9, 2020 - Issue 1
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Research Article

The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

Stine Emilie Weis-Bankea National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkView further author information
,
Mie Linder Hübbea National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkView further author information
,
Morten Orebo Holmströma National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0002-3764-8578View further author information
ORCID Icon,
Mia Aaboe Jørgensena National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkView further author information
,
Simone Kloch Bendtsena National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkView further author information
,
Evelina Martinenaitea National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, Denmark;b IO Biotech ApS, Copenhagen, DenmarkView further author information
,
Marco Carrettaa National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkView further author information
,
Inge Marie Svanea National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0002-9451-6037View further author information
ORCID Icon,
Niels Ødumc Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Ayako Wakatsuki Pedersenb IO Biotech ApS, Copenhagen, DenmarkView further author information
,
Özcan Meta National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0002-3256-7592View further author information
ORCID Icon,
Daniel Hargbøl Madsena National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, DenmarkView further author information
&
Mads Hald Andersena National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Copenhagen, Denmark;b IO Biotech ApS, Copenhagen, Denmark;c Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2914-9605View further author information
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Article: 1771142 | Received 30 Mar 2020, Accepted 15 May 2020, Published online: 01 Jun 2020

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Inés Lecoq, Katharina L. Kopp, Marion Chapellier, Panagiotis Mantas, Evelina Martinenaite, Maria Perez-Penco, Lars Rønn Olsen, Mai-Britt Zocca, Ayako Wakatsuki Pedersen & Mads Hald Andersen. (2022) CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironment. OncoImmunology 11:1.
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Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen & Mads Hald Andersen. (2022) Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment. OncoImmunology 11:1.
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Rasmus Erik Johansson Mortensen, Morten Orebo Holmström, Thomas Landkildehus Lisle, Jane P Hasselby, Gro L Willemoe, Özcan Met, Inge Marie Svane, Julia Johansen, Dorte L Nielsen, Inna M Chen & Mads Hald Andersen. (2023) Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy. Journal for ImmunoTherapy of Cancer 11:3, pages e006432.
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Mads Hald Andersen. (2022) Tumor microenvironment antigens. Seminars in Immunopathology 45:2, pages 253-264.
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Maria Perez-Penco, Stine Emilie Weis-Banke, Aimilia Schina, Majken Siersbæk, Mie Linder Hübbe, Mia Aaboe Jørgensen, Inés Lecoq, Lucia Lara de la Torre, Simone Kloch Bendtsen, Evelina Martinenaite, Morten Orebo Holmström, Daniel Hargbøl Madsen, Marco Donia, Niels Ødum, Lars Grøntved & Mads Hald Andersen. (2022) TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer. Journal for ImmunoTherapy of Cancer 10:12, pages e005491.
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A. Giannoudis, D. Varešlija, V. Sharma, R. Zakaria, A. Platt-Higgins, P.S. Rudland, M.D. Jenkinson, L.S. Young & C. Palmieri. (2022) Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression. ESMO Open 7:6, pages 100636.
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Zhuozhuo Li, Liwei Wang, Yuanyuan Ren, Yaoyao Huang, Wenxuan Liu, Ziwei Lv, Lu Qian, Yi Yu & Yuyan Xiong. (2022) Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases. Cell Death Discovery 8:1.
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Stine Emilie Weis-Banke, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Morten Orebo Holmström, Mia Aaboe Jørgensen, Inge Marie Svane, Özcan Met, Niels Ødum, Daniel Hargbøl Madsen, Marco Donia, Lars Grøntved & Mads Hald Andersen. (2022) Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells. Journal for ImmunoTherapy of Cancer 10:10, pages e005326.
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Marcin Mikołaj Grzybowski, Paulina Seweryna Stańczak, Paulina Pomper, Roman Błaszczyk, Bartłomiej Borek, Anna Gzik, Julita Nowicka, Karol Jędrzejczak, Joanna Brzezińska, Tomasz Rejczak, Nazan Cemre Güner-Chalimoniuk, Agnieszka Kikulska, Michał Mlącki, Jolanta Pęczkowicz-Szyszka, Jacek Olczak, Adam Gołębiowski, Karolina Dzwonek, Paweł Dobrzański & Zbigniew Zasłona. (2022) OATD-02 Validates the Benefits of Pharmacological Inhibition of Arginase 1 and 2 in Cancer. Cancers 14:16, pages 3967.
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Ana Caruntu, Liliana Moraru, Diana Alina Ciubotaru, Cristiana Tanase, Cristian Scheau & Constantin Caruntu. (2022) Assessment of Serum Urea, Creatinine and Uric Acid in Oral Cancer. Journal of Clinical Medicine 11:12, pages 3459.
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Fanglin Niu, Yi Yu, Zhuozhuo Li, Yuanyuan Ren, Zi Li, Qiang Ye, Ping Liu, Chenshuang Ji, Lu Qian & Yuyan Xiong. (2022) Arginase: An emerging and promising therapeutic target for cancer treatment. Biomedicine & Pharmacotherapy 149, pages 112840.
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Moufida Souid, Randa Ghedira, Sameh Souissi, Nadia Bouzgarrou, Sallouha Gabbouj, Salwa Shini-Hadhri, Mohamed-Saleh Rhim, Asma Boukadida, Dhekra Toumi, Raja Faleh, Noureddine Bouaouina, Abdelfatteh Zakhama & Elham Hassen. (2022) Arginase is involved in cervical lesions progression and severity. Immunobiology 227:2, pages 152189.
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Mia Aaboe Jørgensen, Stefano Ugel, Mie Linder Hübbe, Marco Carretta, Maria Perez-Penco, Stine Emilie Weis-Banke, Evelina Martinenaite, Katharina Kopp, Marion Chapellier, Annalisa Adamo, Francesco De Sanctis, Cristina Frusteri, Manuela Iezzi, Mai-Britt Zocca, Daniel Hargbøll Madsen, Ayako Wakatsuki Pedersen, Vincenzo Bronte & Mads Hald Andersen. (2021) Arginase 1–Based Immune Modulatory Vaccines Induce Anticancer Immunity and Synergize with Anti–PD-1 Checkpoint Blockade. Cancer Immunology Research 9:11, pages 1316-1326.
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Emma Hajaj, Marco Sciacovelli, Christian Frezza & Ayelet Erez. (2021) The context-specific roles of urea cycle enzymes in tumorigenesis. Molecular Cell 81:18, pages 3749-3759.
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Claire André & Yves Claude Guillaume. (2021) Development of a new nano arginase HPLC capillary column for the fast screening of arginase inhibitors and evaluation of their binding affinity. Journal of Chromatography B 1175, pages 122751.
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Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch & Mads Hald Andersen. (2021) Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms. Frontiers in Oncology 11.
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Morten Orebo Holmström, Rasmus Erik Johansson Mortensen, Angelos Michail Pavlidis, Evelina Martinenaite, Stine Emilie Weis-Banke, Mia Aaboe-Jørgensen, Simone Kloch Bendtsen, Özcan Met, Ayako Wakatsuki Pedersen, Marco Donia, Inge Marie Svane & Mads Hald Andersen. (2021) Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner. Cellular & Molecular Immunology 18:2, pages 415-426.
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Mie Linder Hübbe, Ditte Elisabeth Jæhger, Thomas Lars Andresen & Mads Hald Andersen. (2020) Leveraging Endogenous Dendritic Cells to Enhance the Therapeutic Efficacy of Adoptive T-Cell Therapy and Checkpoint Blockade. Frontiers in Immunology 11.
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