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OncoImmunology Volume 9, 2020 - Issue 1
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Research Article

IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils

Melanie Kienzla Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria;b BioTechMed, Graz, AustriaView further author information
,
Carina Hasenoehrla Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, AustriaView further author information
,
Paulina Valadez-Cosmesa Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, AustriaView further author information
,
Kathrin Maitza Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, AustriaView further author information
,
Arailym Sarsembayevaa Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, AustriaView further author information
,
Eva Sturma Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, AustriaView further author information
,
Akos Heinemanna Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria;b BioTechMed, Graz, AustriaView further author information
,
Julia Kargla Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, AustriaView further author information
&
Rudolf Schichoa Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria;b BioTechMed, Graz, AustriaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5726-4731View further author information
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Article: 1776059 | Received 04 Feb 2020, Accepted 22 May 2020, Published online: 16 Jun 2020

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Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dusica Ristic, Sofia Raftopoulou, Ana Santiso, Thomas Bärnthaler, Luka Brcic, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Gerd Geisslinger, Julia Kargl & Rudolf Schicho. (2021) Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. OncoImmunology 10:1.
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Articles from other publishers (37)

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Melanie Kienzl, Kathrin Maitz, Arailym Sarsembayeva, Paulina Valadez-Cosmes, Eva Gruden, Dusica Ristic, Karolina Herceg, Julia Kargl & Rudolf Schicho. (2024) Comparative Study of the Immune Microenvironment in Heterotopic Tumor Models. Cancers 16:2, pages 295.
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Min Yu, Qian Zhang, Luying Wan, Shixuan Wang, Lifang Zou, Zhiwei Chen & Fei Li. (2023) IL-1R8 expression in DLBCL regulates NK cell recruitment and influences patient prognosis. Functional & Integrative Genomics 23:4.
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Junshu Li, Yanhong Ji, Na Chen, Lei Dai & Hongxin Deng. (2023) Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota. Cell & Bioscience 13:1.
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Nurhaslina Hasan, Narimah Abdul Hamid Hasani, Effat Omar, Fatihah Ronny Sham, Syed Baharom Syed Ahmad Fuad, Muhammad Khalis Abdul Karim & Mohammad Johari Ibahim. (2023) A single targeted gamma-ray irradiation induced an acute modulation of immune cells and related cytokines in EMT6 mouse-bearing tumour model. Cancer Biomarkers 38:1, pages 61-75.
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Eva Gruden, Melanie Kienzl, Carina Hasenoehrl, Arailym Sarsembayeva, Dusica Ristic, Sophie Theresa Schmid, Kathrin Maitz, Ulrike Taschler, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Julia Kargl & Rudolf Schicho. (2023) Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles. Prostaglandins, Leukotrienes and Essential Fatty Acids 196, pages 102585.
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Damian Jacenik, Ioannis Karagiannidis & Ellen J. Beswick. (2022) Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. British Journal of Cancer 128:2, pages 387-397.
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Arailym Sarsembayeva, Melanie Kienzl, Eva Gruden, Dusica Ristic, Kathrin Maitz, Paulina Valadez-Cosmes, Ana Santiso, Carina Hasenoehrl, Luka Brcic, Jörg Lindenmann, Julia Kargl & Rudolf Schicho. (2023) Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells. Frontiers in Immunology 13.
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Xiao Liu & Qianqian Cui. (2022) Identification of CISD1 as a Prognostic Biomarker for Breast Cancer. International Journal of General Medicine Volume 15, pages 8451-8465.
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Runzi Sun, David Shihong Gao, Jason Shoush & Binfeng Lu. (2022) The IL-1 family in tumorigenesis and antitumor immunity. Seminars in Cancer Biology 86, pages 280-295.
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Han Guo, Elhusseny A. Bossila, Xinran Ma, Chenxu Zhao & Yong Zhao. (2022) Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions. Cells 11:20, pages 3237.
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Eric Jou, Noe Rodriguez-Rodriguez & Andrew N. J. McKenzie. (2022) Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis. Frontiers in Immunology 13.
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Mohammad Hossein Mirzapour, Mahsa Heidari-Foroozan, Sepideh Razi & Nima Rezaei. (2022) The pro-tumorigenic responses in metastatic niches: an immunological perspective. Clinical and Translational Oncology 25:2, pages 333-344.
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Christoph Bergmann, Aurélie Poli, Ioana Agache, Rodolfo Bianchini, Heather J. Bax, Mariana Castells, Silvia Crescioli, David Dombrowicz, Denisa Ferastraoaru, Edda Fiebiger, Hannah J. Gould, Karin Hartmann, Elena Izquierdo, Galateja Jordakieva, Debra H. Josephs, Marek Jutel, Francesca Levi‐Schaffer, Leticia de las Vecillas, Michael T. Lotze, Gabriel Osborn, Mariona Pascal, Frank Redegeld, David Rosenstreich, Franziska Roth‐Walter, Carsten Schmidt‐Weber, Mohamed Shamji, Esther H. Steveling, Michelle C. Turner, Eva Untersmayr, Erika Jensen‐Jarolim & Sophia N. Karagiannis. (2022) AllergoOncology: Danger signals in allergology and oncology: A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper. Allergy 77:9, pages 2594-2617.
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Guoquan Yin, Chen Zhao & Weiya Pei. (2022) Crosstalk between macrophages and innate lymphoid cells (ILCs) in diseases. International Immunopharmacology 110, pages 108937.
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Wen Jie Yeoh, Vivian P. Vu & Philippe Krebs. (2022) IL-33 biology in cancer: An update and future perspectives. Cytokine 157, pages 155961.
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Long Xu, Yang Yang, Yankai Wen, Jong-Min Jeong, Christoph Emontzpohl, Constance L. Atkins, Zhaoli Sun, Kyle L. Poulsen, David R. Hall, J. Steve Bynon, Bin Gao, William M. Lee, Jody Rule, Elizabeth A. Jacobsen, Hua Wang & Cynthia Ju. (2022) Hepatic recruitment of eosinophils and their protective function during acute liver injury. Journal of Hepatology 77:2, pages 344-352.
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Ajaz A. Bhat, Sabah Nisar, Mayank Singh, Bazella Ashraf, Tariq Masoodi, Chandra P. Prasad, Atul Sharma, Selma Maacha, Thasni Karedath, Sheema Hashem, Syed Besina Yasin, Puneet Bagga, Ravinder Reddy, Michael P. Frennaux, Shahab Uddin, Punita Dhawan, Mohammad Haris & Muzafar A. Macha. (2022) Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy. Cancer Communications 42:8, pages 689-715.
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Gaelen K. Dwyer, Louise M. D'CruzHēth R. Turnquist. (2022) Emerging Functions of IL-33 in Homeostasis and Immunity. Annual Review of Immunology 40:1, pages 15-43.
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Lindsey Carlsen, Kelsey E. Huntington & Wafik S. El-Deiry. (2022) Immunotherapy for Colorectal Cancer: Mechanisms and Predictive Biomarkers. Cancers 14:4, pages 1028.
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Cristiana Cairo & Tonya J. Webb. (2022) Effective Barriers: The Role of NKT Cells and Innate Lymphoid Cells in the Gut. The Journal of Immunology 208:2, pages 235-246.
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Fang Huang, Wan-Yuan Chen, Jie Ma, Xiang-Lei He & Jian-Wei Wang. (2022) Paradoxical role of interleukin-33/suppressor of tumorigenicity 2 in colorectal carcinogenesis: Progress and therapeutic potential. World Journal of Clinical Cases 10:1, pages 23-34.
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Alexandre Corthay & Guttorm Haraldsen. 2022. Biomarkers of the Tumor Microenvironment. Biomarkers of the Tumor Microenvironment 195 205 .
Sofía Frigerio, Dalia A. Lartey, Geert R. D’Haens & Joep Grootjans. (2021) The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms. International Journal of Molecular Sciences 22:23, pages 12739.
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Petra Luschnig, Melanie Kienzl, David Roula, Johannes Pilic, Reham Atallah, Akos Heinemann & Eva M. Sturm. (2021) The JAK1/2 inhibitor baricitinib suppresses eosinophil effector function and restricts allergen-induced airway eosinophilia. Biochemical Pharmacology 192, pages 114690.
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Aurélie Poncin, Concetta Elisa Onesti, Claire Josse, Delphine Boulet, Jérôme Thiry, Vincent Bours & Guy Jerusalem. (2021) Immunity and Breast Cancer: Focus on Eosinophils. Biomedicines 9:9, pages 1087.
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Wenyi Jiang, Jingyao Lian, Ying Yue & Yi Zhang. (2021) IL‐33/ST2 as a potential target for tumor immunotherapy. European Journal of Immunology 51:8, pages 1943-1955.
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Timothée Fettrelet, Lea Gigon, Alexander Karaulov, Shida Yousefi & Hans-Uwe Simon. (2021) The Enigma of Eosinophil Degranulation. International Journal of Molecular Sciences 22:13, pages 7091.
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Mi-Ran Choi, Jeffrey A. Sosman & Bin Zhang. (2021) The Janus Face of IL-33 Signaling in Tumor Development and Immune Escape. Cancers 13:13, pages 3281.
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Eva Maria Sturm, Eva Knuplez & Gunther Marsche. (2021) Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases. International Journal of Molecular Sciences 22:9, pages 4377.
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Eva Knuplez, Eva Maria Sturm & Gunther Marsche. (2021) Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids. International Journal of Molecular Sciences 22:9, pages 4356.
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Jesse D. Armitage, Hannah V. Newnes, Alison McDonnell, Anthony Bosco & Jason Waithman. (2021) Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression. Cells 10:1, pages 56.
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Sara Andreone, Adriana Rosa Gambardella, Jacopo Mancini, Stefania Loffredo, Simone Marcella, Valentina La Sorsa, Gilda Varricchi, Giovanna Schiavoni & Fabrizio Mattei. (2020) Anti-Tumorigenic Activities of IL-33: A Mechanistic Insight. Frontiers in Immunology 11.
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