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OncoImmunology Volume 9, 2020 - Issue 1
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Original Research

Baseline plasma levels of soluble PD-1, PD-L1, and BTN3A1 predict response to nivolumab treatment in patients with metastatic renal cell carcinoma: a step toward a biomarker for therapeutic decisions

Lorena Incorvaiaa Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.n.d.), Section of Medical Oncology, University of Palermo, Palermo, ItalyORCID Iconhttps://orcid.org/0000-0002-1199-7286
ORCID Icon,
Daniele Fanaleb Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, ItalyORCID Iconhttps://orcid.org/0000-0001-7668-737X
ORCID Icon,
Giuseppe Badalamentib Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Camillo Portac Department of Biomedical Sciences and Human Oncology, University of Bari ‘A.moro’ and Division of Oncology, Policlinico Consorziale, Bari, ItalyORCID Iconhttps://orcid.org/0000-0003-2412-1563
ORCID Icon,
Daniel Olived Team Immunity and Cancer, Centre De Recherche En Cancérologie De Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France
,
Ida De Lucab Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Chiara Brandob Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
,
Mimma Rizzoe Division of Translational Oncology, I.R.C.C.S. Istituti Clinici Scientifici Maugeri, Pavia, ItalyORCID Iconhttps://orcid.org/0000-0001-7743-741X
ORCID Icon,
Carlo Messinaf Department of Medical Oncology, Santa Chiara Hospital, Trento, Italy
,
Mattia Reditig Breast Cancer Translational Research Laboratory, Jules Bordet Institut, L’Université Libre De Brussels, Belgium
,
Antonio Russob Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, ItalyCorrespondence[email protected]
,
Viviana Bazana Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.n.d.), Section of Medical Oncology, University of Palermo, Palermo, Italy
&
Juan Lucio Iovannah Team Pancreatic Cancer, Centre De Recherche En Cancérologie De Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique Et Technologique De Luminy, Marseille, FranceORCID Iconhttps://orcid.org/0000-0003-1822-2237
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Article: 1832348 | Received 03 Sep 2020, Accepted 30 Sep 2020, Published online: 27 Oct 2020

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Guichan Liao, Ziying Liu, Muye Xia, Hongjie Chen, Houji Wu, Bing Li, Tao Yu, Shaohang Cai, Xiaoyong Zhang & Jie Peng. (2022) Soluble Programmed Cell Death-1 is a Novel Predictor of HBsAg Loss in Chronic Hepatitis B Patients When Long-Term Nucleos(t)ide Analog Treatment is Discontinued. Infection and Drug Resistance 15, pages 2347-2357.
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Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang & Peng Luo. (2023) Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment. Molecular Cancer 22:1.
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M. La Mantia, S. Cutaia, V. Gristina, A. Galvano, E. Capoluongo, C. Rolfo, U. Malapelle, L. Incorvaia, G. Badalamenti, A. Russo & V. Bazan. 2023. Liquid Biopsy. Liquid Biopsy 31 45 .
L. Incorvaia, A. Perez, C. Brando, V. Gristina, M. La Mantia, M. Castiglia, D. Fanale, A. Galvano, G. Badalamenti, A. Russo & V. Bazan. 2023. Liquid Biopsy. Liquid Biopsy 83 117 .
E. Capoluongo, P. Pisapia, U. Malapelle & G. Troncone. 2023. Liquid Biopsy. Liquid Biopsy 119 202 .
M. La Mantia, F. Iacono, S. Cutaia, V. Gristina, A. Perez, M. Greco, K. Calcara, A. Galvano, V. Bazan & A. Russo. 2023. Liquid Biopsy. Liquid Biopsy 203 209 .
Kelsey E. Huntington & Wafik S. El-Deiry. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 44 .
Antonio G. Solimando & Domenico Ribatti. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 21 .
Alessandra Dimino, Chiara Brando, Laura Algeri, Valerio Gristina, Erika Pedone, Marta Peri, Alessandro Perez, Ida De Luca, Roberta Sciacchitano, Luigi Magrin, Tancredi Didier Bazan Russo, Marco Bono, Nadia Barraco, Silvia Contino, Maria La Mantia, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan & Lorena Incorvaia. (2022) Exploring the Dynamic Crosstalk between the Immune System and Genetics in Gastrointestinal Stromal Tumors. Cancers 15:1, pages 216.
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Lorena Incorvaia, Valerio Gristina, Chiara Brando, Maria La Mantia & Antonio Russo. 2022. Cardio-Oncology. Cardio-Oncology 1 4 .
Alessandra Cinque, Anna Capasso, Riccardo Vago, Michael W Lee, Matteo Floris & Francesco Trevisani. (2021) The Role of Circulating Biomarkers in the Oncological Management of Metastatic Renal Cell Carcinoma: Where Do We Stand Now?. Biomedicines 10:1, pages 90.
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Lorena Incorvaia, Giuseppe Procopio & Camillo Porta. 2021. Practical Medical Oncology Textbook. Practical Medical Oncology Textbook 755 774 .
Pierosandro Tagliaferri & Pierfrancesco Tassone. 2021. Practical Medical Oncology Textbook. Practical Medical Oncology Textbook 391 399 .
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