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OncoImmunology Volume 9, 2020 - Issue 1
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Original Research

TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer

Ralph Ja Maasa Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-3185-5226View further author information
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Janneke S Hoogstad-van Everta Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands;b Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-9838-0977View further author information
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Jolien Mr Van der Meera Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-9288-1500View further author information
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Vera Mekersa Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-6989-7619View further author information
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Somayeh Rezaeifarda Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-3720-3875View further author information
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Alan J Kormanc Bristol-Myers Squibb, Redwood City, CA, USA;;d AK Vir Biotechnology, San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-1142-8542View further author information
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Paul Kjd de Jongea Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-1228-5002View further author information
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Jeannette Canya Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsView further author information
,
Rob Woestenenka Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsView further author information
,
Nicolaas Pm Schaape Department of Hematology, Radboud University Medical Center/Radboud Institute for Molecular Life Sciences, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-7696-4752View further author information
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Leon F Massugerb Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The NetherlandsView further author information
,
Joop H Jansena Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-9459-568XView further author information
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Willemijn Hoboa Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-8206-8185View further author information
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Harry Dolstraa Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3998-687XView further author information
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Article: 1843247 | Received 11 May 2020, Accepted 25 Oct 2020, Published online: 08 Nov 2020

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Pooya Farhangnia, Mahzad Akbarpour, Mahboubeh Yazdanifar, Amir Reza Aref, Ali-Akbar Delbandi & Nima Rezaei. (2022) Advances in therapeutic targeting of immune checkpoints receptors within the CD96-TIGIT axis: clinical implications and future perspectives. Expert Review of Clinical Immunology 18:12, pages 1217-1237.
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Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek & Jitka Fucikova. (2021) TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients. OncoImmunology 10:1.
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Articles from other publishers (43)

Siyue Jiang, Wenhua Wang & Yongxiu Yang. (2024) TIGIT: A potential immunotherapy target for gynecological cancers. Pathology - Research and Practice 255, pages 155202.
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Yuzhu Hou, Xiujun Zhao & Xiaoqian Nie. (2024) Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review). Oncology Reports 51:3.
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Peng Zhang, Xinyuan Liu, Zhuoyu Gu, Zhongxing Jiang, Song Zhao, Yongping Song & Jifeng Yu. (2024) Targeting TIGIT for cancer immunotherapy: recent advances and future directions. Biomarker Research 12:1.
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Lingfei Li, Ang Li, Hai Jin, Mingyang Li & Qingge Jia. (2024) Inhibitory receptors and checkpoints on NK cells: Implications for cancer immunotherapy. Pathology - Research and Practice 253, pages 155003.
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Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Slivova, MacKenzie McIntosh, Karen E. Pollok & Sandro Matosevic. (2023) TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma. iScience 26:12, pages 108353.
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Hengyi Xu, Ziqi Jia, Fengshuo Liu, Jiayi Li, Yansong Huang, Yiwen Jiang, Pengming Pu, Tongxuan Shang, Pengrui Tang, Yongxin Zhou, Yufan Yang, Jianzhong Su & Jiaqi Liu. (2023) Biomarkers and experimental models for cancer immunology investigation. MedComm 4:6.
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Zhe Geng, Xinxing Pan, Juan Xu & Xuemei Jia. (2022) Friend and foe: the regulation network of ascites components in ovarian cancer progression. Journal of Cell Communication and Signaling 17:3, pages 391-407.
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Chunxue Zhang, Yaru Sheng, Xiao Sun & Yudong Wang. (2023) New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions. Cancer and Metastasis Reviews 42:3, pages 891-925.
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Luiz Ricardo Soldi, Victor Luigi Costa Silva, Diogo Henrique Rabelo, Isadora Akemi Uehara & Marcelo José Barbosa Silva. (2023) Reactivation of natural killer cells with monoclonal antibodies in the microenvironment of malignant neoplasms. Journal of Cancer Research and Clinical Oncology 149:9, pages 6661-6673.
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Junpeng Zhao, Liming Li, Huiqi Yin, Xiwei Feng & Qianjin Lu. (2023) TIGIT: An emerging immune checkpoint target for immunotherapy in autoimmune disease and cancer. International Immunopharmacology 120, pages 110358.
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Valentina Carannante, Martin Wiklund & Björn Önfelt. (2023) In vitro models to study natural killer cell dynamics in the tumor microenvironment. Frontiers in Immunology 14.
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Dong-Hyeon Jo, Shelby Kaczmarek, Oksu Shin, Lisheng Wang, Juthaporn Cowan, Scott McComb & Seung-Hwan Lee. (2023) Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles. Molecular Therapy - Methods & Clinical Development 29, pages 173-184.
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Irina Buckle, Anthony Johnson, Ingrid Leal Rojas, Vicky Weinert, David P. Sester, Kristen Radford & Camille Guillerey. (2023) High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood. European Journal of Immunology 53:6.
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Md Faqrul Hasan, Tayler J. Croom-Perez, Jeremiah L. Oyer, Thomas A. Dieffenthaller, Liza D. Robles-Carrillo, Jonathan E. Eloriaga, Sanjana Kumar, Brendan W. Andersen & Alicja J. Copik. (2023) TIGIT Expression on Activated NK Cells Correlates with Greater Anti-Tumor Activity but Promotes Functional Decline upon Lung Cancer Exposure: Implications for Adoptive Cell Therapy and TIGIT-Targeted Therapies. Cancers 15:10, pages 2712.
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Doryssa Hermans, Lisa van Beers & Bieke Broux. (2023) Nectin Family Ligands Trigger Immune Effector Functions in Health and Autoimmunity. Biology 12:3, pages 452.
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Kangdi Yang, Yuze Zhao, Guanqun Sun, Xu Zhang, Jinjin Cao, Mingcong Shao, Xijun Liang & Lina Wang. (2023) Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy. Frontiers in Immunology 13.
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Cid Almeida de Lima, Millena Prata Jammal, Renata Margarida Etchebehere, Eddie Fernando Candido Murta & Rosekeila Simões Nomelini. (2023) Immunostaining of stromal CD56 cells in ovarian malignancies. Revista da Associação Médica Brasileira 69:6.
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Munawaer Muaibati, Abasi Abuduyilimu, Tao Zhang, Yun Dai, Ruyuan Li, Fanwei Huang, Kexin Li, Qing Tong, Xiaoyuan Huang & Liang Zhuang. (2023) Efficacy of immune checkpoint inhibitor monotherapy or combined with other small molecule-targeted agents in ovarian cancer. Expert Reviews in Molecular Medicine 25.
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Taiqing Liu, Yinqi Li, Xiaoyu Wang, Xiaodong Yang, Yunhai Fu, Yeteng Zheng, Hanlin Gong & Zhiyao He. (2022) The role of interferons in ovarian cancer progression: Hinderer or promoter?. Frontiers in Immunology 13.
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Anna Pawłowska, Wiktoria Skiba, Dorota Suszczyk, Weronika Kuryło, Joanna Jakubowicz-Gil, Roman Paduch & Iwona Wertel. (2022) The Dual Blockade of the TIGIT and PD-1/PD-L1 Pathway as a New Hope for Ovarian Cancer Patients. Cancers 14:23, pages 5757.
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Alberto Mendoza-Valderrey, Maite Alvarez, Andrea De Maria, Kim Margolin, Ignacio Melero & Maria Libera Ascierto. (2022) Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity. Cells 11:19, pages 3147.
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Madhuri Dey, Myong Hwan Kim, Momoka Nagamine, Ece Karhan, Lina Kozhaya, Mikail Dogan, Derya Unutmaz & Ibrahim T Ozbolat. (2022) Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors. Biofabrication 14:4, pages 044105.
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Chunping Liu, Dongyue He, Longmei Li, Shihui Zhang, Lei Wang, Zhijin Fan & Yichao Wang. (2022) Extracellular vesicles in pancreatic cancer immune escape: Emerging roles and mechanisms. Pharmacological Research 183, pages 106364.
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Haoyu Wang, Jingchun Liu, Jiang Yang, Zhi Wang, Zihui Zhang, Jiaxin Peng, Ying Wang & Li Hong. (2022) A novel tumor mutational burden-based risk model predicts prognosis and correlates with immune infiltration in ovarian cancer. Frontiers in Immunology 13.
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Antonio Valeri, Almudena García-Ortiz, Eva Castellano, Laura Córdoba, Elena Maroto-Martín, Jessica Encinas, Alejandra Leivas, Paula Río & Joaquín Martínez-López. (2022) Overcoming tumor resistance mechanisms in CAR-NK cell therapy. Frontiers in Immunology 13.
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Zhijie Xu, Bi Peng, Fanhua Kang, Wenqin Zhang, Muzhang Xiao, Jianbo Li, Qianhui Hong, Yuan Cai, Wei Liu, Yuanliang Yan & Jinwu Peng. (2022) The Roles of Drug Metabolism-Related ADH1B in Immune Regulation and Therapeutic Response of Ovarian Cancer. Frontiers in Cell and Developmental Biology 10.
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Louisa Bolm, Natalie Petruch, Shivan Sivakumar, Nicola E Annels & Adam Enver Frampton. (2022) Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). Journal of Clinical Pathology 75:4, pages 217-221.
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Wanze Zhang, Zhenghua Zhao & Fan Li. (2022) Natural killer cell dysfunction in cancer and new strategies to utilize NK cell potential for cancer immunotherapy. Molecular Immunology 144, pages 58-70.
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Daijun Wang, Yanmei Gu, Xin Yan, Chengdong Huo, Guan Wang, Yang Zhao, Muzhou Teng & Yumin Li. (2022) Role of CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy. Frontiers in Oncology 12.
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Sophie Rovers, Annelies Janssens, Jo Raskin, Patrick Pauwels, Jan P. van Meerbeeck, Evelien Smits & Elly Marcq. (2022) Recent Advances of Immune Checkpoint Inhibition and Potential for (Combined) TIGIT Blockade as a New Strategy for Malignant Pleural Mesothelioma. Biomedicines 10:3, pages 673.
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Chen Zhao, Kewei Xiong, Fangrui Zhao, Abdalla Adam & Xiangpan Li. (2022) Glycosylation-Related Genes Predict the Prognosis and Immune Fraction of Ovarian Cancer Patients Based on Weighted Gene Coexpression Network Analysis (WGCNA) and Machine Learning. Oxidative Medicine and Cellular Longevity 2022, pages 1-23.
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Dechao Feng, Xu Shi, Qiao Xiong, Facai Zhang, Dengxiong Li, Wuran Wei & Lu Yang. (2022) A Ferroptosis-Related Gene Prognostic Index Associated With Biochemical Recurrence and Radiation Resistance for Patients With Prostate Cancer Undergoing Radical Radiotherapy. Frontiers in Cell and Developmental Biology 10.
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Morgan Pugh-Toole, Anna P. Nicolela, Sarah Nersesian, Brendan M. Leung & Jeanette E. Boudreau. (2022) Natural Killer Cells: the Missing Link in Effective Treatment for High-Grade Serous Ovarian Carcinoma. Current Treatment Options in Oncology 23:2, pages 210-226.
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Baokang Wu, Chongli Zhong, Qi Lang, Zhiyun Liang, Yizhou Zhang, Xin Zhao, Yang Yu, Heming Zhang, Feng Xu & Yu Tian. (2021) Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy. Journal of Experimental & Clinical Cancer Research 40:1.
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Franziska Brauneck, Elisa Seubert, Jasmin Wellbrock, Julian Schulze zur Wiesch, Yinghui Duan, Tim Magnus, Carsten Bokemeyer, Friedrich Koch-Nolte, Stephan Menzel & Walter Fiedler. (2021) Combined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML. International Journal of Molecular Sciences 22:23, pages 12919.
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Irina Buckle & Camille Guillerey. (2021) Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer. Cancers 13:17, pages 4263.
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Zhouhong Ge, Maikel P. Peppelenbosch, Dave Sprengers & Jaap Kwekkeboom. (2021) TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer. Frontiers in Immunology 12.
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Alessandro Poggi, Federico Villa, Jordi Leonardo Castrillo Fernadez, Delfina Costa, Maria Raffaella Zocchi & Roberto Benelli. (2021) Three-Dimensional Culture Models to Study Innate Anti-Tumor Immune Response: Advantages and Disadvantages. Cancers 13:14, pages 3417.
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Jing Gu & Fangfang Bi. (2021) Significance of N6-Methyladenosine RNA Methylation Regulators in Immune Infiltrates of Ovarian Cancer. Frontiers in Genetics 12.
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Ishwar Navin, Michael T. Lam & Robin Parihar. (2020) Design and Implementation of NK Cell-Based Immunotherapy to Overcome the Solid Tumor Microenvironment. Cancers 12:12, pages 3871.
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